CA3046849A1 - Methods and apparatus for magnetic multi-bead assays - Google Patents

Methods and apparatus for magnetic multi-bead assays Download PDF

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Publication number
CA3046849A1
CA3046849A1 CA3046849A CA3046849A CA3046849A1 CA 3046849 A1 CA3046849 A1 CA 3046849A1 CA 3046849 A CA3046849 A CA 3046849A CA 3046849 A CA3046849 A CA 3046849A CA 3046849 A1 CA3046849 A1 CA 3046849A1
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CA
Canada
Prior art keywords
type
functionalized
bead
functionalized beads
magnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3046849A
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English (en)
French (fr)
Inventor
Colin B. CONNOLLY
Jeffrey D. Randall
John C. Pena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quantum Diamond Technologies (United States)
Original Assignee
Quantum Diamond Technologies (United States)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Diamond Technologies (United States) filed Critical Quantum Diamond Technologies (United States)
Publication of CA3046849A1 publication Critical patent/CA3046849A1/en
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/10—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/24—Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/26—Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/323—Detection of MR without the use of RF or microwaves, e.g. force-detected MR, thermally detected MR, MR detection via electrical conductivity, optically detected MR

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CA3046849A 2016-12-23 2017-12-22 Methods and apparatus for magnetic multi-bead assays Pending CA3046849A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662438593P 2016-12-23 2016-12-23
US62/438,593 2016-12-23
PCT/US2017/068126 WO2018119367A1 (en) 2016-12-23 2017-12-22 Methods and apparatus for magnetic multi-bead assays

Publications (1)

Publication Number Publication Date
CA3046849A1 true CA3046849A1 (en) 2018-06-28

Family

ID=62627136

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3046849A Pending CA3046849A1 (en) 2016-12-23 2017-12-22 Methods and apparatus for magnetic multi-bead assays

Country Status (5)

Country Link
US (2) US11513115B2 (https=)
EP (1) EP3559668B1 (https=)
JP (1) JP7249281B2 (https=)
CA (1) CA3046849A1 (https=)
WO (1) WO2018119367A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10845449B2 (en) 2016-10-20 2020-11-24 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic particle analysis using diamond magnetic imaging
JP7249281B2 (ja) 2016-12-23 2023-03-30 クアンタム ダイヤモンド テクノロジーズ インク． 磁気式多ビーズアッセイのための方法および装置
ES2932362T3 (es) 2017-07-31 2023-01-18 Quantum Diamond Tech Inc Sistema sensor que comprende un cartucho de muestras que incluye una membrana flexible para soportar una muestra
JP7417220B2 (ja) * 2019-05-24 2024-01-18 国立大学法人大阪大学 撮像装置および撮像方法
JP7392336B2 (ja) * 2019-09-06 2023-12-06 株式会社島津製作所 磁気共鳴分光装置および磁気共鳴分光の測定方法
CA3161172A1 (en) * 2019-11-12 2021-05-20 Quantum Diamond Technologies Inc. Bead systems, methods, and apparatus for magnetic bead-based analyte detection
US11971464B1 (en) * 2019-12-20 2024-04-30 The United States Of America, Represented By The Secretary Of The Navy Magnon excitation and detection systems, apparatus, and methods
JP7529446B2 (ja) * 2020-06-05 2024-08-06 株式会社エイアンドティー フィブリノゲン測定方法
US12560597B2 (en) * 2020-06-15 2026-02-24 Case Western Reserve University Point of care device for early and rapid disease diagnosis
KR102313685B1 (ko) * 2020-07-13 2021-10-18 한양대학교 산학협력단 Dnv 센터를 이용한 형광신호 측정 시스템
US11585870B2 (en) * 2020-09-15 2023-02-21 Massachusetts Institute Of Technology Absorption-based diamond spin microscopy on a plasmonic quantum metasurface
JP7585341B2 (ja) * 2020-10-28 2024-11-18 京セラ株式会社 磁気センサ及び検出システム
FR3120127B1 (fr) * 2021-02-24 2023-09-15 Magia Diagnostics Procede et dispositif d’analyse d’un liquide susceptible de contenir un analyte
EP4453569A4 (en) * 2021-12-20 2025-10-15 Hach Co METHODS AND KITS FOR ASSAYING A LARGE VOLUME OF FLUID BY FLOW CYTOMETRY
AU2023208644A1 (en) * 2022-01-24 2024-07-04 Amgen Inc. Methods for detecting antibody self-association
JP7812074B2 (ja) * 2022-07-29 2026-02-09 スミダコーポレーション株式会社 測定装置および測定方法
DE102023100856B4 (de) * 2023-01-16 2024-10-02 Quantum Technologies Gmbh Schnelle, zeitlich und räumlich hochauflösende Magnetfeldkamera

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2045431B (en) 1979-02-26 1983-04-20 Technicon Instr Immunoassay utilising two particulate reagents
US4628037A (en) 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4695392A (en) 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US5145784A (en) 1988-05-04 1992-09-08 Cambridge Biotech Corporation Double capture assay method employing a capillary flow device
CA2013014A1 (en) 1989-11-30 1991-05-31 Linda A. Mauck Dry immunoassay analytical element comprising monodispersed beads
US5547555A (en) 1993-02-22 1996-08-20 Ohmicron Technology, Inc. Electrochemical sensor cartridge
US5648124A (en) 1993-07-09 1997-07-15 Seradyn, Inc. Process for preparing magnetically responsive microparticles
JP3854680B2 (ja) 1997-02-26 2006-12-06 キヤノン株式会社 圧力隔壁およびこれを用いた露光装置
US5998224A (en) 1997-05-16 1999-12-07 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US6050138A (en) 1997-10-22 2000-04-18 Exponent, Inc. System and method for performing bulge testing of films, coatings and/or layers
US6979424B2 (en) 1998-03-17 2005-12-27 Cepheid Integrated sample analysis device
ES2284274T3 (es) 1998-06-17 2007-11-01 Ohio University Precipitador electrostatico con membrana.
US6178033B1 (en) 1999-03-28 2001-01-23 Lucent Technologies Micromechanical membrane tilt-mirror switch
WO2001034290A2 (en) 1999-11-09 2001-05-17 Sri International Array for generating combinatorial libraries
US7635571B2 (en) 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
US6896850B2 (en) 2001-03-26 2005-05-24 Kumetrix, Inc. Silicon nitride window for microsampling device and method of construction
US7474180B2 (en) 2002-11-01 2009-01-06 Georgia Tech Research Corp. Single substrate electromagnetic actuator
WO2004052046A2 (en) 2002-11-27 2004-06-17 Northwestern University Thin membrane transducer
DE10309132A1 (de) * 2003-02-28 2004-11-18 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zum selektiven Nachweis magnetischer Partikel
CA2525810A1 (en) 2003-05-14 2005-03-03 Nantero, Inc. Sensor platform using a horizontally oriented nanotube element
US7279286B2 (en) 2003-09-11 2007-10-09 Sanofi-Aventis Deutschland Gmbh High-throughput-assay with high sensitivity for measuring of the activity of β-adrenergic receptor kinase and for determining the impact of test substances on such activity
US7531366B2 (en) * 2004-07-23 2009-05-12 Platypus Technologies, Llc Bead based assays using a liquid crystal reporter
EP1662256A1 (en) 2004-11-25 2006-05-31 Spinomix S.A. Tailored magnetic particles and method to produce same
US7489593B2 (en) 2004-11-30 2009-02-10 Vermon Electrostatic membranes for sensors, ultrasonic transducers incorporating such membranes, and manufacturing methods therefor
WO2006079998A1 (en) 2005-01-31 2006-08-03 Koninklijke Philips Electronics N.V. Rapid and sensitive biosensing
US20070103697A1 (en) 2005-06-17 2007-05-10 Degertekin Fahrettin L Integrated displacement sensors for probe microscopy and force spectroscopy
US8220318B2 (en) 2005-06-17 2012-07-17 Georgia Tech Research Corporation Fast microscale actuators for probe microscopy
US7637149B2 (en) 2005-06-17 2009-12-29 Georgia Tech Research Corporation Integrated displacement sensors for probe microscopy and force spectroscopy
US20090165876A1 (en) 2005-11-22 2009-07-02 Micah James Atkin Microfluidic Structures
CA2656686A1 (en) 2006-07-05 2008-01-10 Aida Engineering, Ltd. Micro passage chip and fluid transferring method
US20080108122A1 (en) 2006-09-01 2008-05-08 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Microchemical nanofactories
WO2008030960A2 (en) 2006-09-06 2008-03-13 The Board Of Trustees Of The University Of Illinois Controlled buckling structures in semiconductor interconnects and nanomembranes for stretchable electronics
EP2074421B1 (en) 2006-10-12 2014-12-17 Koninklijke Philips N.V. Fast biosensor with reagent layer
US10529003B2 (en) 2008-04-07 2020-01-07 Mohammad A. Mazed Optical biomodule for detection of diseases at an early onset
US7863035B2 (en) 2007-02-15 2011-01-04 Osmetech Technology Inc. Fluidics devices
US20090134481A1 (en) 2007-11-28 2009-05-28 Analog Devices, Inc. Molded Sensor Package and Assembly Method
EP2108938A1 (en) 2008-04-09 2009-10-14 Koninklijke Philips Electronics N.V. A carrier for optical detection in small sample volumes
US8500637B2 (en) 2008-07-14 2013-08-06 Ecole Polytechnique Federale De Lausanne (Epfl) Viscosimetric biosensor for monitoring analyte levels
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US8766630B2 (en) 2008-11-04 2014-07-01 The University Of Melbourne Method and apparatus for monitoring a property of a sample
EP2391883B1 (en) 2009-01-30 2018-03-07 Micronics, Inc. Portable high gain fluorescence detection system
US8059271B2 (en) 2009-02-04 2011-11-15 The United States Of America As Represented By The Secretary Of The Army Reusable sample holding device permitting ready loading of very small wet samples
WO2010091344A1 (en) 2009-02-06 2010-08-12 The Ohio State University Magnetic platforms for biomolecule trappings, manipulations, and sorting
FI122507B (fi) 2009-05-26 2012-02-29 Outotec Oyj Analysaattorin mittausikkunan sovitelma
CA2768873A1 (en) 2009-07-23 2011-01-27 Insight Nanofluidics Inc. Nanofluidic cell
WO2011026030A1 (en) 2009-08-31 2011-03-03 Mbio Diagnostics Corporation Integrated sample preparation and analyte detection
US8193808B2 (en) * 2009-09-11 2012-06-05 Hewlett-Packard Development Company, L.P. Optically integrated biosensor based on optically detected magnetic resonance
FR2950153B1 (fr) 2009-09-15 2011-12-23 Commissariat Energie Atomique Dispositif optique a membrane deformable a actionnement piezoelectrique
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
WO2012010251A1 (en) 2010-07-23 2012-01-26 Merck Patent Gmbh Method of performing an assay
GB201014805D0 (en) 2010-09-07 2010-10-20 Multi Sense Technologies Ltd Microfluidics based assay device
JP2012121748A (ja) 2010-12-07 2012-06-28 Sumitomo Electric Ind Ltd ダイヤモンド及びこれを用いた磁気センサー
WO2012103511A2 (en) 2011-01-27 2012-08-02 Invisible Sentinel, Inc. Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof
US8989354B2 (en) 2011-05-16 2015-03-24 Brigham Young University Carbon composite support structure
GB201108644D0 (en) * 2011-05-24 2011-07-06 Element Six Ltd Diamond sensors, detectors, and quantum devices
GB2497317A (en) 2011-12-06 2013-06-12 Univ Dublin System and method for the detection of analytes using rod-shaped nanoparticles
EP2769417A4 (en) 2011-10-19 2015-05-27 Univ Columbia SYSTEMS AND METHOD FOR DETERMINISTIC EMITTER SWITCH MICROSCOPY
US9632045B2 (en) * 2011-10-19 2017-04-25 The Trustees Of Columbia University In The City Of New York Systems and methods for deterministic emitter switch microscopy
KR20130051647A (ko) 2011-11-10 2013-05-21 한국전자통신연구원 자성 입자를 이용한 바이오 물질의 분석 방법
US9797817B2 (en) 2012-05-03 2017-10-24 The Regents Of The University Of Michigan Multi-mode separation for target detection
EP2872892B1 (en) 2012-07-10 2017-12-20 Lexogen GmbH Flexible dna sensor carrier and method
US10041971B2 (en) 2012-08-22 2018-08-07 President And Fellows Of Harvard College Nanoscale scanning sensors
JP2014095025A (ja) 2012-11-08 2014-05-22 Osaka Univ ダイヤモンド複合粒子
US9551704B2 (en) * 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
JP6033959B2 (ja) 2013-01-09 2016-11-30 テカン・トレーディング・アクチェンゲゼルシャフトＴＥＣＡＮ Ｔｒａｄｉｎｇ ＡＧ マイクロ流体システム用使い捨てカートリッジ
WO2014210486A1 (en) 2013-06-28 2014-12-31 Dirk Robert Englund Wide-field sensing using nitrogen vacancies
US9778329B2 (en) 2014-02-19 2017-10-03 Infinitum Solutions, Inc. Integrated optical nanoscale probe measurement of electric fields from electric charges in electronic devices
US9910105B2 (en) 2014-03-20 2018-03-06 Lockheed Martin Corporation DNV magnetic field detector
JP6298728B2 (ja) 2014-06-26 2018-03-20 ルネサスエレクトロニクス株式会社 磁気計測装置
US9435791B2 (en) 2014-06-27 2016-09-06 Verily Life Sciences, LLC Method for using nanodiamonds to detect nearby magnetic nanoparticles
EP3248021A4 (en) 2015-01-23 2018-12-12 Lockheed Martin Corporation Dnv magnetic field detector
JP2016188828A (ja) 2015-03-30 2016-11-04 東ソー株式会社 磁気信号を利用した標的物質の測定方法
JP6655415B2 (ja) 2016-02-16 2020-02-26 ルネサスエレクトロニクス株式会社 磁気計測装置
US10845449B2 (en) 2016-10-20 2020-11-24 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic particle analysis using diamond magnetic imaging
JP7249281B2 (ja) 2016-12-23 2023-03-30 クアンタム ダイヤモンド テクノロジーズ インク． 磁気式多ビーズアッセイのための方法および装置
IT201700017061A1 (it) 2017-02-15 2018-08-15 Technoprobe Spa Scheda di misura perfezionata per applicazioni ad alta frequenza
ES2932362T3 (es) 2017-07-31 2023-01-18 Quantum Diamond Tech Inc Sistema sensor que comprende un cartucho de muestras que incluye una membrana flexible para soportar una muestra
CA3161172A1 (en) 2019-11-12 2021-05-20 Quantum Diamond Technologies Inc. Bead systems, methods, and apparatus for magnetic bead-based analyte detection

Also Published As

Publication number Publication date
US11513115B2 (en) 2022-11-29
JP7249281B2 (ja) 2023-03-30
US20190331674A1 (en) 2019-10-31
JP2020514709A (ja) 2020-05-21
EP3559668A1 (en) 2019-10-30
EP3559668B1 (en) 2023-07-19
WO2018119367A1 (en) 2018-06-28
EP3559668A4 (en) 2020-07-22
US20230071162A1 (en) 2023-03-09

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