CA3035615A1 - Compositions and methods for treating cancer with duocars - Google Patents

Compositions and methods for treating cancer with duocars Download PDF

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Publication number
CA3035615A1
CA3035615A1 CA3035615A CA3035615A CA3035615A1 CA 3035615 A1 CA3035615 A1 CA 3035615A1 CA 3035615 A CA3035615 A CA 3035615A CA 3035615 A CA3035615 A CA 3035615A CA 3035615 A1 CA3035615 A1 CA 3035615A1
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Prior art keywords
domain
car
binding domain
cells
vectors
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CA3035615A
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English (en)
French (fr)
Inventor
Rimas ORENTAS
Dina SCHNEIDER
Waleed M. HASO
Stefan Miltenyi
Boro Dropulic
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Lentigen Technology Inc
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Lentigen Technology Inc
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Publication of CA3035615A1 publication Critical patent/CA3035615A1/en
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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CA3035615A 2016-09-02 2017-09-01 Compositions and methods for treating cancer with duocars Pending CA3035615A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662382791P 2016-09-02 2016-09-02
US62/382,791 2016-09-02
PCT/US2017/049923 WO2018045325A1 (en) 2016-09-02 2017-09-01 Compositions and methods for treating cancer with duocars

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CA3035615A1 true CA3035615A1 (en) 2018-03-08

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CA3035615A Pending CA3035615A1 (en) 2016-09-02 2017-09-01 Compositions and methods for treating cancer with duocars
CA3113194A Pending CA3113194A1 (en) 2016-09-02 2019-09-18 Compositions and methods for treating cancer with duocars
CA3158878A Pending CA3158878A1 (en) 2016-09-02 2020-11-20 Compositions and methods for treating cancer with duocars

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CA3113194A Pending CA3113194A1 (en) 2016-09-02 2019-09-18 Compositions and methods for treating cancer with duocars
CA3158878A Pending CA3158878A1 (en) 2016-09-02 2020-11-20 Compositions and methods for treating cancer with duocars

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US (9) US11453712B2 (enExample)
EP (4) EP3507304B1 (enExample)
JP (6) JP7160482B2 (enExample)
CN (5) CN117298260A (enExample)
AU (4) AU2017321894B2 (enExample)
CA (3) CA3035615A1 (enExample)
ES (1) ES2981703T3 (enExample)
WO (3) WO2018045325A1 (enExample)

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TWI695067B (zh) 2013-08-05 2020-06-01 美商扭轉生物科技有限公司 重新合成之基因庫
WO2015084513A1 (en) 2013-12-06 2015-06-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thymic stromal lymphopoietin receptor-specific chimeric antigen receptors and methods using same
EP3240805B1 (en) 2014-12-15 2024-11-27 The Regents of the University of California Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
CN108368482A (zh) 2015-09-18 2018-08-03 特韦斯特生物科学公司 寡核酸变体文库及其合成
US11512347B2 (en) 2015-09-22 2022-11-29 Twist Bioscience Corporation Flexible substrates for nucleic acid synthesis
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US20190083596A1 (en) 2019-03-21
JP2023502503A (ja) 2023-01-24
WO2018045325A1 (en) 2018-03-08
AU2019342730A1 (en) 2021-04-01
CA3158878A1 (en) 2021-05-27
CN109843922A (zh) 2019-06-04
WO2020061194A2 (en) 2020-03-26
CN115768462A (zh) 2023-03-07
WO2021102337A1 (en) 2021-05-27
JP7160482B2 (ja) 2022-10-25
AU2020386636A1 (en) 2022-06-09
JP7423610B2 (ja) 2024-01-29
EP3507304A1 (en) 2019-07-10
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US11453712B2 (en) 2022-09-27
AU2020386636A2 (en) 2022-07-14
JP7766595B2 (ja) 2025-11-10
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ES2981703T3 (es) 2024-10-10
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US20200392200A1 (en) 2020-12-17
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US11208455B2 (en) 2021-12-28
JP2022500467A (ja) 2022-01-04
EP4282969A2 (en) 2023-11-29
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US20220169698A1 (en) 2022-06-02
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AU2025200478A1 (en) 2025-02-20
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US20240043497A1 (en) 2024-02-08
US11802142B2 (en) 2023-10-31
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US20250367291A1 (en) 2025-12-04
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