CA3020808A1 - Compositions and methods for the detection of host cell proteins - Google Patents
Compositions and methods for the detection of host cell proteins Download PDFInfo
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- CA3020808A1 CA3020808A1 CA3020808A CA3020808A CA3020808A1 CA 3020808 A1 CA3020808 A1 CA 3020808A1 CA 3020808 A CA3020808 A CA 3020808A CA 3020808 A CA3020808 A CA 3020808A CA 3020808 A1 CA3020808 A1 CA 3020808A1
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- Health & Medical Sciences (AREA)
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| PCT/EP2017/058775 WO2017178526A1 (en) | 2016-04-14 | 2017-04-12 | Compositions and methods for the detection of host cell proteins |
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| CN109564217A (zh) | 2016-04-14 | 2019-04-02 | 隆扎有限公司 | 用于检测宿主细胞蛋白的组合物和方法 |
| US11268951B2 (en) * | 2017-09-20 | 2022-03-08 | Charles River Laboratories International, Inc. | CHO host cell protein assay |
| CN109078628B (zh) * | 2018-08-27 | 2021-06-11 | 西北大学 | 一种以苄胺为配基的高效疏水相互作用色谱介质、制备方法及其在蛋白质复性与纯化的应用 |
| CN111665364B (zh) * | 2019-03-08 | 2025-01-21 | 湖州申科生物技术股份有限公司 | 一种评估hcp检测用多克隆抗体覆盖率的方法 |
| KR20220107586A (ko) | 2021-01-25 | 2022-08-02 | 금오공과대학교 산학협력단 | 전기신호를 이용한 세포수 검출장치 및 이를 이용한 검출방법 |
| CN114966038A (zh) * | 2022-04-13 | 2022-08-30 | 翌圣生物科技(上海)股份有限公司 | 精确定量检测生物医药制品中残留sp2/0宿主细胞蛋白的方法及ELISA检测试剂盒 |
| WO2024084264A1 (en) * | 2022-10-17 | 2024-04-25 | HAJIAN TEHRANI, Behrooz | Immunoassay for detecting host cell proteins of high five cells |
| CN115894677A (zh) * | 2022-12-01 | 2023-04-04 | 湖州申科生物技术股份有限公司 | 一种提高hcp检测抗体覆盖率的抗体组合及其应用 |
| CN117192107A (zh) * | 2023-09-11 | 2023-12-08 | 福建基诺厚普生物科技有限公司 | 一种工艺特异性宿主细胞蛋白残留的检测方法及试剂盒 |
| US20250334572A1 (en) * | 2024-04-26 | 2025-10-30 | Waters Technologies Corporation | Host cell protein detection using lateral flow devices |
| CN118465164B (zh) * | 2024-05-10 | 2025-02-14 | 上海澳斯康生物制药有限公司 | 一种用于检测hcp抗体覆盖率的方法及其应用 |
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| FR2046920B1 (enExample) | 1969-06-19 | 1974-05-03 | Citizen Watch Co Ltd | |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
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| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
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| JP2003516124A (ja) | 1999-10-15 | 2003-05-13 | ユニバーシティー オブ マサチューセッツ | 標的とした遺伝的干渉の手段としてのｒｎａ干渉経路遺伝子 |
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| US20030091976A1 (en) * | 2001-11-14 | 2003-05-15 | Ciphergen Biosystems, Inc. | Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry |
| WO2004094989A2 (en) * | 2003-04-22 | 2004-11-04 | Ciphergen Biosystems, Inc. | Methods of host cell protein analysis |
| WO2005071410A1 (en) | 2004-01-13 | 2005-08-04 | Tanox, Inc. | Detecting and quantifying host cell proteins in recombinant protein products |
| US8728828B2 (en) * | 2004-12-22 | 2014-05-20 | Ge Healthcare Bio-Sciences Ab | Purification of immunoglobulins |
| CN101571549B (zh) * | 2008-04-30 | 2013-08-14 | 上海泽润生物科技有限公司 | Vero细胞HCP检测试剂盒及其应用 |
| CN105111309A (zh) * | 2008-10-20 | 2015-12-02 | Abbvie公司 | 使用a蛋白亲和层析分离和纯化抗体 |
| BR112015009553A2 (pt) | 2012-10-30 | 2017-10-03 | Hoffmann La Roche | Método para separar uma proteína de interesse de uma solução de cultura de células |
| CN103439512B (zh) * | 2013-07-30 | 2014-05-07 | 通化东宝药业股份有限公司 | 一种检测特异性重组人胰岛素大肠杆菌残留宿主蛋白的方法 |
| KR102571391B1 (ko) * | 2013-09-13 | 2023-08-29 | 제넨테크, 인크. | 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물 |
| CN103792366B (zh) * | 2014-01-21 | 2015-09-23 | 内蒙古必威安泰生物科技有限公司 | 口蹄疫疫苗宿主细胞蛋白双抗夹心酶联免疫检测试剂盒及使用方法 |
| CN105021824A (zh) * | 2015-07-06 | 2015-11-04 | 上海优者生物科技有限公司 | 用于定量检测生物医药制品中残留cho宿主细胞蛋白的elisa试剂盒及其使用方法 |
| CN109564217A (zh) | 2016-04-14 | 2019-04-02 | 隆扎有限公司 | 用于检测宿主细胞蛋白的组合物和方法 |
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| WO2017178526A1 (en) | 2017-10-19 |
| IL290358A (en) | 2022-04-01 |
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| EP3683579C0 (en) | 2024-10-23 |
| CN115109148A (zh) | 2022-09-27 |
| AU2017251360A1 (en) | 2018-11-01 |
| EP3443348A1 (en) | 2019-02-20 |
| JP2019516964A (ja) | 2019-06-20 |
| US20220268791A1 (en) | 2022-08-25 |
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| IL262297A (en) | 2018-11-29 |
| US20190128903A1 (en) | 2019-05-02 |
| SG11201808992UA (en) | 2018-11-29 |
| JP7565147B2 (ja) | 2024-10-10 |
| US12203948B2 (en) | 2025-01-21 |
| BR112018071107A2 (pt) | 2019-04-16 |
| KR20180129927A (ko) | 2018-12-05 |
| IL290358B2 (en) | 2024-03-01 |
| EP3683579A1 (en) | 2020-07-22 |
| US20220268792A1 (en) | 2022-08-25 |
| CN109564217A (zh) | 2019-04-02 |
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