CA3016764A1 - Methods for treating patients with hyperlipidemia by administering a pcsk9 inhibitor in combination with an angptl3 inhibitor - Google Patents
Methods for treating patients with hyperlipidemia by administering a pcsk9 inhibitor in combination with an angptl3 inhibitor Download PDFInfo
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- CA3016764A1 CA3016764A1 CA3016764A CA3016764A CA3016764A1 CA 3016764 A1 CA3016764 A1 CA 3016764A1 CA 3016764 A CA3016764 A CA 3016764A CA 3016764 A CA3016764 A CA 3016764A CA 3016764 A1 CA3016764 A1 CA 3016764A1
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Landscapes
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| AU2017258105B2 (en) * | 2016-04-28 | 2024-09-05 | Regeneron Pharmaceuticals, Inc. | Methods for treating patients with familial hypercholesterolemia |
| CN110464842B (zh) * | 2018-05-11 | 2022-10-14 | 信达生物制药(苏州)有限公司 | 包含抗pcsk9抗体的制剂及其用途 |
| EP3993820A4 (en) * | 2019-07-04 | 2023-08-16 | Cadila Healthcare Limited | VACCINE BASED ON ANGPTL3 FOR THE TREATMENT OF LIVER DISEASES |
| CA3188213A1 (en) * | 2020-08-07 | 2022-02-10 | Robert C. Pordy | Methods for treating refractory hypercholesterolemia involving an angptl3 inhibitor |
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| CN101852805B (zh) | 2009-03-31 | 2015-04-01 | 浙江大学 | Angptl3作为卵巢癌的诊断标记物的用途 |
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| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| JO3412B1 (ar) | 2011-06-17 | 2019-10-20 | Regeneron Pharma | أجسام مضادة ل angptl3 واستخداماتها |
| EP3444348A1 (en) | 2011-06-21 | 2019-02-20 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
| US9574005B2 (en) | 2011-07-19 | 2017-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stable Protein-containing preparation containing argininamide or analogous compound thereof |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| EA039663B1 (ru) | 2012-05-03 | 2022-02-24 | Амген Инк. | Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств |
| RU2015119547A (ru) | 2012-10-25 | 2016-12-20 | МЕДИММЬЮН, ЭлЭлСи | Стабильный низковязкий состав с антителом |
| ES2753381T3 (es) | 2013-03-14 | 2020-04-08 | Uab Research Foundation | Miméticos de apolipoproteína y usos de los mismos |
| US10111953B2 (en) * | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| EA201592267A1 (ru) | 2013-06-07 | 2016-04-29 | Ридженерон Фармасьютикалз, Инк. | Способы ингибирования атеросклероза посредством введения ингибитора pcsk9 |
| CA2930069A1 (en) | 2013-11-20 | 2015-05-28 | Cymabay Therapeutics, Inc. | Treatment of homozygous familial hypercholesterolemia |
| US20170037409A1 (en) | 2013-12-24 | 2017-02-09 | Ionis Pharmaceuticals, Inc. | Modulation of angiopoietin-like 3 expression |
| AU2015252895B2 (en) | 2014-05-01 | 2021-07-15 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating angiopoietin-like 3 expression |
| AU2015289617B2 (en) | 2014-07-16 | 2021-04-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating high cardiovascular risk patients with hypercholesterolemia |
| PL3169353T3 (pl) * | 2014-07-16 | 2020-06-01 | Sanofi Biotechnology | SPOSOBY LECZENIA PACJENTÓW Z HETEROZYGOTYCZNĄ HIPERCHOLESTEROLEMIĄ RODZINNĄ (heFH) |
| EP3822287A1 (en) | 2014-10-03 | 2021-05-19 | NGM Biopharmaceuticals, Inc. | Angptl8 polypeptide and its use for treatment of conditions associated with elevated triglycerides |
| TW201713690A (zh) | 2015-08-07 | 2017-04-16 | 再生元醫藥公司 | 抗ａｎｇｐｔｌ８抗體及其用途 |
| IL260931B2 (en) | 2016-02-17 | 2024-09-01 | Regeneron Pharma | Methods of treating or preventing atherosclerosis by blocking ANGPTL3 |
| WO2017151783A1 (en) | 2016-03-03 | 2017-09-08 | Regeneron Pharmaceuticals, Inc. | Methods for treating patients with hyperlipidemia by administering a pcsk9 inhibitor in combination with an angptl3 inhibitor |
| CN109789194B (zh) | 2016-04-08 | 2022-08-02 | 瑞泽恩制药公司 | 用angptl8抑制剂和angptl3抑制剂治疗高脂血症的方法 |
| AU2017258105B2 (en) | 2016-04-28 | 2024-09-05 | Regeneron Pharmaceuticals, Inc. | Methods for treating patients with familial hypercholesterolemia |
| US11603407B2 (en) | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
| US20200369760A1 (en) | 2019-05-24 | 2020-11-26 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-angptl3 antibodies |
| CA3188213A1 (en) | 2020-08-07 | 2022-02-10 | Robert C. Pordy | Methods for treating refractory hypercholesterolemia involving an angptl3 inhibitor |
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- 2017-03-01 JP JP2018545828A patent/JP7541810B2/ja active Active
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- 2017-03-01 AU AU2017227713A patent/AU2017227713B2/en active Active
- 2017-03-01 US US15/446,720 patent/US20170253666A1/en not_active Abandoned
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- 2017-03-01 KR KR1020187028068A patent/KR102456731B1/ko active Active
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| JP2022078306A (ja) | 2022-05-24 |
| IL261420A (en) | 2018-10-31 |
| AU2017227713B2 (en) | 2022-12-22 |
| US12281173B2 (en) | 2025-04-22 |
| US20170253666A1 (en) | 2017-09-07 |
| JP7541810B2 (ja) | 2024-08-29 |
| US20200199253A1 (en) | 2020-06-25 |
| EA201891979A1 (ru) | 2019-01-31 |
| AU2017227713A1 (en) | 2018-09-13 |
| ZA201805403B (en) | 2019-08-28 |
| JP2019512472A (ja) | 2019-05-16 |
| KR20180118181A (ko) | 2018-10-30 |
| KR102456731B1 (ko) | 2022-10-24 |
| MA43734A (fr) | 2018-11-28 |
| WO2017151783A1 (en) | 2017-09-08 |
| JP2024059787A (ja) | 2024-05-01 |
| CN109069868A (zh) | 2018-12-21 |
| MX2018010401A (es) | 2019-03-06 |
| EP3423157A1 (en) | 2019-01-09 |
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