CA3008013A1 - Modified capsid proteins for enhanced delivery of parvovirus vectors - Google Patents

Modified capsid proteins for enhanced delivery of parvovirus vectors Download PDF

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Publication number
CA3008013A1
CA3008013A1 CA3008013A CA3008013A CA3008013A1 CA 3008013 A1 CA3008013 A1 CA 3008013A1 CA 3008013 A CA3008013 A CA 3008013A CA 3008013 A CA3008013 A CA 3008013A CA 3008013 A1 CA3008013 A1 CA 3008013A1
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Prior art keywords
capsid protein
capsid
amino acid
parvovirus
virus vector
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Pending
Application number
CA3008013A
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English (en)
French (fr)
Inventor
Richard Jude Samulski
Jayme WARISCHALK
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of CA3008013A1 publication Critical patent/CA3008013A1/en
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/015—Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/76—Viruses; Subviral particles; Bacteriophages
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14041—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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CA3008013A 2015-12-14 2016-12-14 Modified capsid proteins for enhanced delivery of parvovirus vectors Pending CA3008013A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562266941P 2015-12-14 2015-12-14
US62/266,941 2015-12-14
PCT/US2016/066466 WO2017106236A1 (en) 2015-12-14 2016-12-14 Modified capsid proteins for enhanced delivery of parvovirus vectors

Publications (1)

Publication Number Publication Date
CA3008013A1 true CA3008013A1 (en) 2017-06-22

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CA3008013A Pending CA3008013A1 (en) 2015-12-14 2016-12-14 Modified capsid proteins for enhanced delivery of parvovirus vectors

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US (3) US11124546B2 (enExample)
EP (2) EP4659816A3 (enExample)
JP (3) JP7406783B2 (enExample)
CN (2) CN116478254A (enExample)
AU (2) AU2016371779C1 (enExample)
CA (1) CA3008013A1 (enExample)
DK (1) DK3390429T3 (enExample)
ES (1) ES3040934T3 (enExample)
MX (2) MX395524B (enExample)
PL (1) PL3390429T3 (enExample)
RU (1) RU2751953C2 (enExample)
WO (1) WO2017106236A1 (enExample)

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