CA3006482C - The use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions - Google Patents
The use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions Download PDFInfo
- Publication number
- CA3006482C CA3006482C CA3006482A CA3006482A CA3006482C CA 3006482 C CA3006482 C CA 3006482C CA 3006482 A CA3006482 A CA 3006482A CA 3006482 A CA3006482 A CA 3006482A CA 3006482 C CA3006482 C CA 3006482C
- Authority
- CA
- Canada
- Prior art keywords
- extract
- day
- uvb
- skin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000284 extract Substances 0.000 title claims abstract description 174
- 239000000203 mixture Substances 0.000 title claims abstract description 81
- 239000002537 cosmetic Substances 0.000 title claims abstract description 30
- 210000001916 photosynthetic cell Anatomy 0.000 title claims abstract description 23
- 210000002377 thylakoid Anatomy 0.000 title claims abstract description 13
- 230000000699 topical effect Effects 0.000 claims abstract description 14
- 230000037303 wrinkles Effects 0.000 claims description 25
- 238000006703 hydration reaction Methods 0.000 claims description 12
- 230000036571 hydration Effects 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 6
- 206010013786 Dry skin Diseases 0.000 claims description 4
- 230000037336 dry skin Effects 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 4
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 239000003925 fat Substances 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims description 3
- 239000003349 gelling agent Substances 0.000 claims description 3
- 239000002504 physiological saline solution Substances 0.000 claims description 3
- 239000008247 solid mixture Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 230000006378 damage Effects 0.000 abstract description 35
- 230000001153 anti-wrinkle effect Effects 0.000 abstract description 7
- 230000003712 anti-aging effect Effects 0.000 abstract description 5
- 210000001519 tissue Anatomy 0.000 description 90
- 230000000475 sunscreen effect Effects 0.000 description 53
- 239000000516 sunscreening agent Substances 0.000 description 53
- 210000003491 skin Anatomy 0.000 description 52
- 108020004414 DNA Proteins 0.000 description 50
- 238000011282 treatment Methods 0.000 description 33
- 108091093078 Pyrimidine dimer Proteins 0.000 description 29
- 239000003981 vehicle Substances 0.000 description 26
- 206010040954 Skin wrinkling Diseases 0.000 description 25
- 239000006071 cream Substances 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 20
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 18
- 238000009472 formulation Methods 0.000 description 17
- 230000000451 tissue damage Effects 0.000 description 17
- 230000005778 DNA damage Effects 0.000 description 16
- 231100000277 DNA damage Toxicity 0.000 description 16
- 238000004458 analytical method Methods 0.000 description 16
- 238000000254 composite pulse decoupling sequence Methods 0.000 description 16
- 230000000694 effects Effects 0.000 description 16
- 238000011534 incubation Methods 0.000 description 16
- 230000004224 protection Effects 0.000 description 15
- 238000006722 reduction reaction Methods 0.000 description 15
- 231100000827 tissue damage Toxicity 0.000 description 15
- 239000012634 fragment Substances 0.000 description 14
- 230000006872 improvement Effects 0.000 description 14
- 230000003859 lipid peroxidation Effects 0.000 description 14
- 230000009467 reduction Effects 0.000 description 14
- 210000002615 epidermis Anatomy 0.000 description 12
- 238000001574 biopsy Methods 0.000 description 11
- 239000003642 reactive oxygen metabolite Substances 0.000 description 11
- 238000005259 measurement Methods 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 229940015043 glyoxal Drugs 0.000 description 9
- 210000002510 keratinocyte Anatomy 0.000 description 9
- 230000008439 repair process Effects 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 8
- 230000007935 neutral effect Effects 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 230000002195 synergetic effect Effects 0.000 description 8
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 7
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical group O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 7
- 230000003078 antioxidant effect Effects 0.000 description 7
- 210000001339 epidermal cell Anatomy 0.000 description 7
- 238000001502 gel electrophoresis Methods 0.000 description 7
- 229940118019 malondialdehyde Drugs 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 210000000434 stratum corneum Anatomy 0.000 description 7
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 6
- 230000005779 cell damage Effects 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 229930195729 fatty acid Natural products 0.000 description 6
- 239000000194 fatty acid Substances 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- BXOCHUWSGYYSFW-HVWOQQCMSA-N spilanthol Chemical compound C\C=C\C=C/CC\C=C\C(=O)NCC(C)C BXOCHUWSGYYSFW-HVWOQQCMSA-N 0.000 description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 206010018910 Haemolysis Diseases 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 206010016256 fatigue Diseases 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 230000008588 hemolysis Effects 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 238000001314 profilometry Methods 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 238000001962 electrophoresis Methods 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 238000010166 immunofluorescence Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 239000012188 paraffin wax Substances 0.000 description 4
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 238000007390 skin biopsy Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 239000011547 Bouin solution Substances 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- -1 Lipid peroxides Chemical class 0.000 description 3
- BXOCHUWSGYYSFW-UHFFFAOYSA-N all-trans spilanthol Natural products CC=CC=CCCC=CC(=O)NCC(C)C BXOCHUWSGYYSFW-UHFFFAOYSA-N 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 210000000805 cytoplasm Anatomy 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 230000001473 noxious effect Effects 0.000 description 3
- 230000036542 oxidative stress Effects 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000003244 pro-oxidative effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- 210000003934 vacuole Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241001137251 Corvidae Species 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000000524 Thiobarbituric Acid Reactive Substance Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 208000037887 cell injury Diseases 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000000295 emission spectrum Methods 0.000 description 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 238000002991 immunohistochemical analysis Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229920005573 silicon-containing polymer Polymers 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 230000037067 skin hydration Effects 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 241000283707 Capra Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000028937 DNA protection Effects 0.000 description 1
- 102000004099 Deoxyribonuclease (Pyrimidine Dimer) Human genes 0.000 description 1
- 108010082610 Deoxyribonuclease (Pyrimidine Dimer) Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 101100208473 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) lcm-2 gene Proteins 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical class O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
- 102100022972 Transcription factor AP-2-alpha Human genes 0.000 description 1
- 101710189834 Transcription factor AP-2-alpha Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000006851 antioxidant defense Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001728 carbonyl compounds Chemical class 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 108091092356 cellular DNA Proteins 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- 239000001752 chlorophylls and chlorophyllins Substances 0.000 description 1
- 239000007957 coemulsifier Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000008278 cosmetic cream Substances 0.000 description 1
- UPUOLJWYFICKJI-UHFFFAOYSA-N cyclobutane;pyrimidine Chemical class C1CCC1.C1=CN=CN=C1 UPUOLJWYFICKJI-UHFFFAOYSA-N 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 239000002978 dental impression material Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000013024 dilution buffer Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000001317 epifluorescence microscopy Methods 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000012160 loading buffer Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 239000012120 mounting media Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 231100000589 photocarcinogenesis Toxicity 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 239000012146 running buffer Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000005783 single-strand break Effects 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- VVLFAAMTGMGYBS-UHFFFAOYSA-M sodium;4-[[4-(ethylamino)-3-methylphenyl]-(4-ethylimino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfobenzenesulfonate Chemical compound [Na+].C1=C(C)C(NCC)=CC=C1C(C=1C(=CC(=CC=1)S([O-])(=O)=O)S(O)(=O)=O)=C1C=C(C)C(=NCC)C=C1 VVLFAAMTGMGYBS-UHFFFAOYSA-M 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Birds (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3006482A CA3006482C (en) | 2010-04-12 | 2010-04-12 | The use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2699676A CA2699676C (en) | 2010-04-12 | 2010-04-12 | The use of a photosynthetic cell extract in a cosmetic composition |
| CA3006482A CA3006482C (en) | 2010-04-12 | 2010-04-12 | The use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2699676A Division CA2699676C (en) | 2010-04-12 | 2010-04-12 | The use of a photosynthetic cell extract in a cosmetic composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3006482A1 CA3006482A1 (en) | 2011-10-12 |
| CA3006482C true CA3006482C (en) | 2022-04-19 |
Family
ID=44786861
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3006482A Active CA3006482C (en) | 2010-04-12 | 2010-04-12 | The use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions |
| CA2699676A Active CA2699676C (en) | 2010-04-12 | 2010-04-12 | The use of a photosynthetic cell extract in a cosmetic composition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2699676A Active CA2699676C (en) | 2010-04-12 | 2010-04-12 | The use of a photosynthetic cell extract in a cosmetic composition |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10045934B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3583932A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5952261B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3006482C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2716028T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011127559A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3006482C (en) * | 2010-04-12 | 2022-04-19 | Groupe Sante Devonian | The use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions |
| WO2014158671A1 (en) * | 2013-03-14 | 2014-10-02 | Avon Products, Inc | Abutilon indicum extracts and methods of use |
| WO2024239103A1 (en) * | 2023-05-19 | 2024-11-28 | Bio A3P Inc. | Topical cream for treating dermatological conditions |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3542665B2 (ja) | 1995-07-07 | 2004-07-14 | 株式会社資生堂 | 抗老化皮膚外用剤、コラーゲン架橋阻害皮膚外用剤及び抗紫外線皮膚外用剤 |
| WO2001004042A1 (en) | 1999-07-12 | 2001-01-18 | Wax Technology S.A.S. | Apparatus for dispensing a fluid from container means |
| CA2393816C (en) * | 1999-12-30 | 2013-12-24 | Purecell Technologies Inc. | Process for obtaining thylakoids from photosynthetic organisms; plant fractions obtained from the process; pure thylakoids; and methods of use of thylakoids as ros scavengers, photo-protectors, biosensors, biofilters and bioreactors |
| CA2293852A1 (fr) * | 1999-12-30 | 2001-06-30 | Purecell Technologies Inc. | Procede de preparation d'extraits de plantes actifs et utiles a la capture de radicaux libres; les extraits, et compositions et dispositifs les comprenant |
| ATE304860T1 (de) | 2001-07-02 | 2005-10-15 | Purecell Technologies Inc | Zusammensetzungen enthaltend thylakoids zur modulierung der entzündung |
| JP2005002323A (ja) * | 2003-05-16 | 2005-01-06 | Umeda Jimusho:Kk | 天然系水溶性紫外線吸収剤組成物およびそれを用いた化粧料ならびにビタミンｃの安定化剤 |
| JP2005029483A (ja) * | 2003-07-09 | 2005-02-03 | Maruzen Pharmaceut Co Ltd | 活性酸素消去剤、並びに化粧料及び飲食物 |
| JP4782681B2 (ja) * | 2003-09-22 | 2011-09-28 | ピュアセル・テクノロジーズ・インコーポレーテッド | チラコイドエキスを送達するための経口用組成物および経口投与経路 |
| JP2007070291A (ja) * | 2005-09-07 | 2007-03-22 | Naris Cosmetics Co Ltd | 日焼け止め外用剤 |
| WO2010008333A1 (en) * | 2008-07-14 | 2010-01-21 | Charlotte Erlanson-Albertsson | Large-scale process for the preparation of thylakoids |
| CA3006482C (en) * | 2010-04-12 | 2022-04-19 | Groupe Sante Devonian | The use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions |
-
2010
- 2010-04-12 CA CA3006482A patent/CA3006482C/en active Active
- 2010-04-12 CA CA2699676A patent/CA2699676C/en active Active
-
2011
- 2011-04-12 JP JP2013504072A patent/JP5952261B2/ja active Active
- 2011-04-12 US US13/261,472 patent/US10045934B2/en active Active
- 2011-04-12 ES ES11768299T patent/ES2716028T3/es active Active
- 2011-04-12 WO PCT/CA2011/000372 patent/WO2011127559A1/en not_active Ceased
- 2011-04-12 EP EP18193063.7A patent/EP3583932A1/en not_active Withdrawn
- 2011-04-12 EP EP11768299.7A patent/EP2558062B8/en active Active
-
2016
- 2016-01-29 JP JP2016015343A patent/JP6541589B2/ja active Active
-
2018
- 2018-07-09 US US16/030,485 patent/US10653615B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10045934B2 (en) | 2018-08-14 |
| JP5952261B2 (ja) | 2016-07-13 |
| CA2699676C (en) | 2018-07-17 |
| ES2716028T3 (es) | 2019-06-07 |
| JP6541589B2 (ja) | 2019-07-10 |
| US10653615B2 (en) | 2020-05-19 |
| EP2558062A1 (en) | 2013-02-20 |
| US20130309181A1 (en) | 2013-11-21 |
| US20180325802A1 (en) | 2018-11-15 |
| CA3006482A1 (en) | 2011-10-12 |
| JP2016074737A (ja) | 2016-05-12 |
| JP2013523845A (ja) | 2013-06-17 |
| EP2558062B1 (en) | 2018-12-19 |
| EP3583932A1 (en) | 2019-12-25 |
| WO2011127559A1 (en) | 2011-10-20 |
| EP2558062B8 (en) | 2019-10-02 |
| CA2699676A1 (en) | 2011-10-12 |
| EP2558062A4 (en) | 2015-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101796694B1 (ko) | 피부 미백 및 탄력 제고 화장료 조성물 | |
| BR112020002222A2 (pt) | composições e métodos para melhora da flacidez da pele e do contorno corporal | |
| HK1211866A1 (en) | Antioxidant compositions and methods of using the same | |
| JP4567278B2 (ja) | 皮膚化粧料 | |
| CN111067838A (zh) | 一种美白祛斑组合物，美白祛斑霜及其制备方法 | |
| JP6282582B2 (ja) | 皮膚老化の徴候を低減または遅延させるための、ジンゲロンまたはその誘導体の使用 | |
| US10653615B2 (en) | Use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions | |
| ES2372805T3 (es) | Composiciones de autobronceado que comprenden sulfato de colesterol y dha. | |
| JP2986432B2 (ja) | 非常に少ない用量のメラトニンまたはその類似体を含有する新規局所組成物およびその化粧品における使用 | |
| US20230201094A1 (en) | Personal Care Compositions | |
| RU2675702C1 (ru) | Композиция для уменьшения возрастных нарушений кожи, содержащая ретинальдегид и экстракт Leontopodium alpinum | |
| US7306810B1 (en) | Skin cream | |
| JP4869751B2 (ja) | サンバーンセル形成抑制剤及びｄｎａ損傷修復促進剤 | |
| KR102333132B1 (ko) | 프랜지패니 오일 또는 프랜지패니 오일의 발효물을 포함하는 화장료 조성물 | |
| CN116236426A (zh) | 修红、舒缓护肤组合物及其应用 | |
| KR101145814B1 (ko) | 주름 개선용 조성물 | |
| KR100415430B1 (ko) | 안정화시킨 l-아스코르브산을 함유하는 화장료 조성물 | |
| CN111184655A (zh) | 一种皮肤修复组合物、其制备方法及应用 | |
| KR100769577B1 (ko) | 피부 주름 개선용 화장료 조성물 | |
| BRPI1107447A2 (pt) | Composição cosmética, kit para tratamento da pele, método para tratar pele oleosa ou mista ou pele com acne | |
| KR20050037105A (ko) | 피부 주름 개선용 화장료 조성물 | |
| KR20110101715A (ko) | 주름 개선용 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180529 |