CA2971349C - Potent compstatin analogs - Google Patents

Potent compstatin analogs Download PDF

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Publication number
CA2971349C
CA2971349C CA2971349A CA2971349A CA2971349C CA 2971349 C CA2971349 C CA 2971349C CA 2971349 A CA2971349 A CA 2971349A CA 2971349 A CA2971349 A CA 2971349A CA 2971349 C CA2971349 C CA 2971349C
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Prior art keywords
trp
thr
analog
tryptophan
peptide
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CA2971349A
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English (en)
French (fr)
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CA2971349A1 (en
Inventor
John D. Lambris
Madan Katragadda
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University of Pennsylvania
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University of Pennsylvania
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2971349A 2005-11-28 2006-11-28 Potent compstatin analogs Active CA2971349C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74020505P 2005-11-28 2005-11-28
US60/740,205 2005-11-28
CA2631443A CA2631443C (en) 2005-11-28 2006-11-28 Potent compstatin analogs

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2631443A Division CA2631443C (en) 2005-11-28 2006-11-28 Potent compstatin analogs

Publications (2)

Publication Number Publication Date
CA2971349A1 CA2971349A1 (en) 2007-05-31
CA2971349C true CA2971349C (en) 2020-09-08

Family

ID=37964706

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2971349A Active CA2971349C (en) 2005-11-28 2006-11-28 Potent compstatin analogs
CA2631443A Active CA2631443C (en) 2005-11-28 2006-11-28 Potent compstatin analogs

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2631443A Active CA2631443C (en) 2005-11-28 2006-11-28 Potent compstatin analogs

Country Status (15)

Country Link
US (5) US7888323B2 (enExample)
EP (4) EP3363810A1 (enExample)
JP (2) JP5302004B2 (enExample)
CN (3) CN106188239B (enExample)
BR (1) BRPI0619023B1 (enExample)
CA (2) CA2971349C (enExample)
DK (1) DK1960422T3 (enExample)
ES (3) ES2390828T3 (enExample)
HR (1) HRP20120621T1 (enExample)
IL (2) IL191674A (enExample)
PL (1) PL1960422T3 (enExample)
PT (1) PT1960422E (enExample)
RS (1) RS52429B (enExample)
RU (2) RU2474586C2 (enExample)
WO (1) WO2007062249A2 (enExample)

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CN102977191B (zh) 2016-08-10
IL191674A (en) 2015-04-30
EP1960422A2 (en) 2008-08-27
JP2013177403A (ja) 2013-09-09
ES2677619T3 (es) 2018-08-03
US20190016758A1 (en) 2019-01-17
CA2631443C (en) 2017-09-19
BRPI0619023B1 (pt) 2022-09-27
CN106188239B (zh) 2020-01-07
EP2377877B1 (en) 2018-03-28
IL191674A0 (en) 2009-02-11
EP2377878A1 (en) 2011-10-19
EP2377878B1 (en) 2018-03-28
US20170305971A1 (en) 2017-10-26
RS52429B (sr) 2013-02-28
US7888323B2 (en) 2011-02-15
ES2390828T3 (es) 2012-11-16
DK1960422T3 (da) 2012-08-13
EP2377877A1 (en) 2011-10-19
CN106188239A (zh) 2016-12-07
EP1960422B1 (en) 2012-05-30
PL1960422T3 (pl) 2012-11-30
ES2677947T3 (es) 2018-08-07
CN101400692A (zh) 2009-04-01
WO2007062249A2 (en) 2007-05-31
RU2008126232A (ru) 2010-01-10
US20120004393A1 (en) 2012-01-05
US9169307B2 (en) 2015-10-27
JP5927139B2 (ja) 2016-05-25
CA2971349A1 (en) 2007-05-31
PT1960422E (pt) 2012-08-16
US20080227717A1 (en) 2008-09-18
BRPI0619023A2 (pt) 2011-09-20
HRP20120621T1 (hr) 2012-09-30
RU2012147267A (ru) 2014-05-20
RU2656102C2 (ru) 2018-05-31
WO2007062249A3 (en) 2007-09-13
CN101400692B (zh) 2013-01-02
AU2006318333A1 (en) 2007-05-31
RU2474586C2 (ru) 2013-02-10
IL237915B (en) 2018-11-29
JP2009517476A (ja) 2009-04-30
HK1124621A1 (en) 2009-07-17
US20160096866A1 (en) 2016-04-07
EP3363810A1 (en) 2018-08-22
CN102977191A (zh) 2013-03-20
JP5302004B2 (ja) 2013-10-02
CA2631443A1 (en) 2007-05-31

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