CA2967432A1 - Animal model for dry eye and methods of use of such animals - Google Patents

Animal model for dry eye and methods of use of such animals Download PDF

Info

Publication number
CA2967432A1
CA2967432A1 CA2967432A CA2967432A CA2967432A1 CA 2967432 A1 CA2967432 A1 CA 2967432A1 CA 2967432 A CA2967432 A CA 2967432A CA 2967432 A CA2967432 A CA 2967432A CA 2967432 A1 CA2967432 A1 CA 2967432A1
Authority
CA
Canada
Prior art keywords
candidate agent
scopolamine
administered
benzalkonium chloride
dry eye
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2967432A
Other languages
English (en)
French (fr)
Inventor
Ming Yuan
Ying Hu
Jingtai Cao
Carmelo Romano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CA2967432A1 publication Critical patent/CA2967432A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Animal Husbandry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Urology & Nephrology (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Educational Technology (AREA)
  • Educational Administration (AREA)
  • Business, Economics & Management (AREA)
  • Pure & Applied Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
CA2967432A 2014-12-02 2015-12-01 Animal model for dry eye and methods of use of such animals Abandoned CA2967432A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086263P 2014-12-02 2014-12-02
US62/086,263 2014-12-02
PCT/US2015/063084 WO2016089807A1 (en) 2014-12-02 2015-12-01 Animal model for dry eye and methods of use of such animals

Publications (1)

Publication Number Publication Date
CA2967432A1 true CA2967432A1 (en) 2016-06-09

Family

ID=55024246

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2967432A Abandoned CA2967432A1 (en) 2014-12-02 2015-12-01 Animal model for dry eye and methods of use of such animals

Country Status (14)

Country Link
US (1) US20170360013A1 (enExample)
EP (1) EP3226853B1 (enExample)
JP (1) JP6692808B2 (enExample)
KR (1) KR20170100483A (enExample)
CN (1) CN107106553A (enExample)
AU (1) AU2015355169A1 (enExample)
CA (1) CA2967432A1 (enExample)
ES (1) ES2759729T3 (enExample)
IL (1) IL252077A0 (enExample)
MX (1) MX2017007295A (enExample)
RU (1) RU2706787C2 (enExample)
SG (1) SG11201703572SA (enExample)
WO (1) WO2016089807A1 (enExample)
ZA (1) ZA201703052B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190068575A (ko) * 2016-10-14 2019-06-18 이콤 메디칼 게엠베하 안구 표면 항상성의 확립, 회복 및 보존 방법
WO2019202017A1 (en) 2018-04-18 2019-10-24 i.com medical GmbH High molecular weight hyaluronic acid for treatment and prevention of severe ocular surface disease
US12268706B2 (en) 2019-01-31 2025-04-08 i.com medical GmbH Hyaluronic acid for relief of idiopathic ocular pain
KR102429281B1 (ko) * 2020-05-25 2022-08-05 (주)노바셀테크놀로지 신규 안구건조증 치료용 약학적 조성물
CN113519461A (zh) * 2021-07-06 2021-10-22 江西中洪博元生物技术有限公司 伴刀豆球蛋白a诱导的小鼠干眼症模型的构建方法及应用
WO2023215261A1 (en) * 2022-05-02 2023-11-09 Ocular Services On Demand, Llc Mammalian eye models

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003532629A (ja) * 1999-09-08 2003-11-05 ワトソン ファーマシューティカルズ， インコーポレイテッド 第４アンモニウム塩の経皮薬剤放出への使用
JP5878172B2 (ja) * 2010-07-29 2016-03-08 ラボラトワール フルニエ エスアーエス 炎症性眼疾患の治療／予防用化合物

Also Published As

Publication number Publication date
ES2759729T3 (es) 2020-05-12
JP6692808B2 (ja) 2020-05-13
EP3226853A1 (en) 2017-10-11
RU2017118978A (ru) 2019-01-09
CN107106553A (zh) 2017-08-29
MX2017007295A (es) 2018-03-12
ZA201703052B (en) 2019-03-27
IL252077A0 (en) 2017-07-31
RU2017118978A3 (enExample) 2019-06-04
SG11201703572SA (en) 2017-05-30
WO2016089807A1 (en) 2016-06-09
US20170360013A1 (en) 2017-12-21
EP3226853B1 (en) 2019-09-04
JP2018500546A (ja) 2018-01-11
KR20170100483A (ko) 2017-09-04
RU2706787C2 (ru) 2019-11-21
AU2015355169A1 (en) 2017-05-25

Similar Documents

Publication Publication Date Title
Xie et al. Erythropoietin protects the inner blood–retinal barrier by inhibiting microglia phagocytosis via Src/Akt/cofilin signalling in experimental diabetic retinopathy
EP3226853B1 (en) Animal model for dry eye and methods of use of such animals
De Paiva et al. Dry eye–induced conjunctival epithelial squamous metaplasia is modulated by interferon-γ
Baudouin et al. In vitro and in vivo experimental studies on trabecular meshwork degeneration induced by benzalkonium chloride (an American Ophthalmological Society thesis)
Yang et al. Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells
Luo et al. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1
Cao et al. Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage
Pattabiraman et al. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork
JP6612247B2 (ja) 眼の感染症および疾患を処置するための組成物および方法
Lee et al. Corneal lymphangiogenesis in dry eye disease is regulated by substance P/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3
Barsegian et al. Corneal neuropathy: an underrated manifestation of diabetes mellitus
JP7624220B2 (ja) 自己抗体媒介性眼疾患の治療および診断
Ciprandi et al. Terfenadine exerts antiallergic activity reducing ICAM‐1 expression on nasal epithelial cells in patients with pollen allergy
Feng et al. Detecting A-beta deposition and RPE cell senescence in the retinas of SAMP8 mice
US20200054745A1 (en) Methods for treatment of age-related macular degeneration
Vitar et al. Topical neurokinin-1 receptor antagonist Fosaprepitant ameliorates ocular graft-versus-host disease in a preclinical mouse model
Zhang et al. Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy
Jin et al. Anti-inflammatory effects of glycine thymosin β4 eye drops in experimental dry eye
Fan et al. Extensive Sub-RPE complement deposition in a nonhuman primate model of early-stage diabetic retinopathy
EP2870971B1 (en) Drug for preventing/treating ocular disease
Salica et al. Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization
JP2021523116A (ja) マイボーム腺再生を促進するためのｐｅｄｆ由来ペプチドおよびその使用
JP5800263B2 (ja) アレルギー性鼻炎治療剤のスクリーニング方法およびその利用
KR101794225B1 (ko) 안지오제닌을 유효성분으로 함유하는 각막 내피의 창상 치료용 약학조성물
JP2018508514A (ja) ドライアイ疾患を治療及び／又は予防するための短い合成ペプチドの使用

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20220222

FZDE Discontinued

Effective date: 20220222