CA2967248A1 - Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions - Google Patents
Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions Download PDFInfo
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- CA2967248A1 CA2967248A1 CA2967248A CA2967248A CA2967248A1 CA 2967248 A1 CA2967248 A1 CA 2967248A1 CA 2967248 A CA2967248 A CA 2967248A CA 2967248 A CA2967248 A CA 2967248A CA 2967248 A1 CA2967248 A1 CA 2967248A1
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- Prior art keywords
- compound
- pharmaceutically acceptable
- treatment
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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| EP3268036A1 (en) | 2015-03-10 | 2018-01-17 | GlaxoSmithKline Biologicals S.A. | Compositions and uses |
| JP6744622B2 (ja) * | 2016-06-16 | 2020-08-19 | 学校法人上智学院 | ピペリジン化合物の製造方法 |
| RU2758686C2 (ru) * | 2016-08-08 | 2021-11-01 | Мерк Патент Гмбх | Антагонисты tlr7/8 и их применение |
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| AU2018392213B2 (en) | 2017-12-20 | 2021-03-04 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
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| TW202348237A (zh) | 2021-05-13 | 2023-12-16 | 美商基利科學股份有限公司 | TLR8調節化合物及抗HBV siRNA療法之組合 |
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| AU2022298639C1 (en) | 2021-06-23 | 2025-07-17 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
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| GB0610666D0 (en) | 2006-05-30 | 2006-07-05 | Glaxo Group Ltd | Fluid dispenser |
| PT2125792E (pt) * | 2007-02-19 | 2011-03-01 | Glaxosmithkline Llc | Derivados de purina como imunomoduladores |
| MX2011001662A (es) * | 2008-08-11 | 2011-03-24 | Glaxosmithkline Llc | Derivados de purina para usarse en el tratamiento de enfermedades alergicas, inflamatorias e infecciosas. |
| UA103195C2 (uk) * | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| EP2320905B1 (en) * | 2008-08-11 | 2017-06-28 | Glaxosmithkline LLC | Novel adenine derivatives |
| SI2341933T1 (en) | 2008-10-24 | 2018-03-30 | Glaxosmithkline Biologicals Sa | Lipidated imidazoquinoline derivatives |
| EA026557B1 (ru) * | 2008-12-09 | 2017-04-28 | Джилид Сайэнс, Инк. | Промежуточные соединения для получения модуляторов толл-подобных рецепторов |
| CN102469790B (zh) | 2009-08-07 | 2014-12-03 | 葛兰素史密丝克莱恩生物有限公司 | 脂质化氧代腺嘌呤衍生物 |
| EA021048B1 (ru) * | 2010-02-10 | 2015-03-31 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Малеат 6-амино-2-{[(1s)-1-метилбутил]окси}-9-[5-(1-пиперидинил)пентил]-7,9-дигидро-8н-пурин-8-она |
| JP2013519644A (ja) | 2010-02-10 | 2013-05-30 | グラクソスミスクライン エルエルシー | プリン誘導体およびそれらの薬学的使用 |
| BR112017009648A2 (pt) * | 2014-11-13 | 2017-12-19 | Glaxosmithkline Biologicals Sa | composto, métodos para tratamento de doenças alérgicas ou outras condições inflamatórias ou prevenção de doença, de rinite alérgica ou asma, composição, e, uso de um composto. |
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| BE1023340A1 (fr) | 2017-02-08 |
| CN107108628A (zh) | 2017-08-29 |
| US20180291026A1 (en) | 2018-10-11 |
| BE1023340B1 (fr) | 2017-02-08 |
| WO2016075661A1 (en) | 2016-05-19 |
| ES2917887T3 (es) | 2022-07-12 |
| US20200223849A1 (en) | 2020-07-16 |
| US10919894B2 (en) | 2021-02-16 |
| MX2017006302A (es) | 2018-02-16 |
| US10584125B2 (en) | 2020-03-10 |
| BR112017009648A2 (pt) | 2017-12-19 |
| EP3218377B1 (en) | 2022-04-13 |
| JP2017533925A (ja) | 2017-11-16 |
| EP3218377A1 (en) | 2017-09-20 |
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