CA2965208C - Methods for detecting cardiac damage - Google Patents

Methods for detecting cardiac damage Download PDF

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Publication number
CA2965208C
CA2965208C CA2965208A CA2965208A CA2965208C CA 2965208 C CA2965208 C CA 2965208C CA 2965208 A CA2965208 A CA 2965208A CA 2965208 A CA2965208 A CA 2965208A CA 2965208 C CA2965208 C CA 2965208C
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ctnt
cardiac
heart
ctni
levels
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CA2965208A
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English (en)
French (fr)
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CA2965208A1 (en
Inventor
Xinhua Yan
Anthony O. Caggiano
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Acorda Therapeutics Inc
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Acorda Therapeutics Inc
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061Muscle cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1883Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4712Muscle proteins, e.g. myosin, actin, protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/324Coronary artery diseases, e.g. angina pectoris, myocardial infarction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
CA2965208A 2007-05-10 2008-05-12 Methods for detecting cardiac damage Active CA2965208C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92854107P 2007-05-10 2007-05-10
US60928541 2007-05-10
CA2686959A CA2686959C (en) 2007-05-10 2008-05-12 Methods for detecting cardiac damage

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2686959A Division CA2686959C (en) 2007-05-10 2008-05-12 Methods for detecting cardiac damage

Publications (2)

Publication Number Publication Date
CA2965208A1 CA2965208A1 (en) 2008-11-20
CA2965208C true CA2965208C (en) 2022-06-14

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CA2965208A Active CA2965208C (en) 2007-05-10 2008-05-12 Methods for detecting cardiac damage
CA2686959A Active CA2686959C (en) 2007-05-10 2008-05-12 Methods for detecting cardiac damage

Family Applications After (1)

Application Number Title Priority Date Filing Date
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Country Status (11)

Country Link
US (5) US8628929B2 (cg-RX-API-DMAC7.html)
EP (1) EP2153228A4 (cg-RX-API-DMAC7.html)
JP (5) JP5749490B2 (cg-RX-API-DMAC7.html)
CN (2) CN101743474B (cg-RX-API-DMAC7.html)
AU (1) AU2008251822B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0810631A2 (cg-RX-API-DMAC7.html)
CA (2) CA2965208C (cg-RX-API-DMAC7.html)
IN (1) IN2014MN01227A (cg-RX-API-DMAC7.html)
MX (2) MX348082B (cg-RX-API-DMAC7.html)
RU (1) RU2498309C2 (cg-RX-API-DMAC7.html)
WO (1) WO2008140814A1 (cg-RX-API-DMAC7.html)

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CN101743474B (zh) 2007-05-10 2015-06-03 阿索尔达治疗公司 检测心脏损伤的方法
AU2009282455B2 (en) 2008-08-15 2016-05-12 Acorda Therapeutics, Inc. Compositions and methods for treatment during non-acute periods following CNS neurological injury
WO2010033249A2 (en) 2008-09-22 2010-03-25 Massachusetts Institute Of Technology Compositions of and methods using ligand dimers
JP5743898B2 (ja) * 2008-11-28 2015-07-01 ゼンサン (シャンハイ) サイエンス アンド テクノロジー リミテッド ニューレグリンペプチド及びその使用
US8652788B2 (en) * 2009-12-02 2014-02-18 Abbott Laboratories Assay for diagnosis of cardiac myocyte damage
US8835120B2 (en) * 2009-12-02 2014-09-16 Abbott Laboratories Assay for cardiac troponin-T (cTnT)
EP2555788B1 (en) * 2010-03-24 2017-10-11 Massachusetts Institute of Technology NEUREGULIN DIMER FOR AN ErbB/HER RECEPTOR FOR USE IN REDUCING CARDIOTOXICITY.
JP5676763B2 (ja) * 2010-08-26 2015-02-25 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 動脈性高血圧症から心不全への初期移行の評価におけるバイオマーカーの使用
US10670611B2 (en) 2014-09-26 2020-06-02 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
RU2585391C1 (ru) * 2014-12-19 2016-05-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Чеченский государственный университет Способ иммунологического прогнозирования малых повреждений миокарда
WO2017053794A1 (en) * 2015-09-25 2017-03-30 Sawyer Douglas B Methods for treating cardiac injury
RU2648529C1 (ru) * 2016-12-27 2018-03-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Способ оценки эффективности лекарственной терапии у взрослых пациентов с острой сердечной недостаточностью после операций на открытом сердце, получающих лечение методом экстракорпоральной мембранной оксигенации
RU2709458C2 (ru) * 2017-12-22 2019-12-18 Марина Александровна Чичкова Способ оптимизации ранней иммунологической диагностики осложнений чрескожного коронарного вмешательства у пациентов с ИБС
RU2722111C1 (ru) * 2019-12-30 2020-05-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ ведения пациентов с хроническим лимфолейкозом в процессе полихимиотерапии по схеме fcr, направленный на предотвращение кардиотоксичности
RU2749552C1 (ru) * 2020-08-03 2021-06-15 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Способ отбора пациентов с длительно персистирующей формой фибрилляции предсердий на проведение эффективного катетерного лечения
RU2760242C1 (ru) * 2021-03-01 2021-11-23 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации Способ оценки повреждения миокарда и риска развития осложнений после операций на сердце в условиях искусственного кровообращения
CN113238060B (zh) * 2021-05-08 2022-10-11 迈克生物股份有限公司 用于预测或诊断心肌炎的试剂盒

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CN1715926B (zh) * 2004-07-02 2011-08-17 上海泽生科技开发有限公司 神经调节蛋白突变体的应用
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CN101743474B (zh) 2007-05-10 2015-06-03 阿索尔达治疗公司 检测心脏损伤的方法
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JP2013535507A (ja) 2010-08-13 2013-09-12 ジョージタウン ユニバーシティ Ggf2および使用方法

Also Published As

Publication number Publication date
CN104614510A (zh) 2015-05-13
AU2008251822A1 (en) 2008-11-20
US10258667B2 (en) 2019-04-16
RU2498309C2 (ru) 2013-11-10
WO2008140814A1 (en) 2008-11-20
JP5998171B2 (ja) 2016-09-28
US9329171B2 (en) 2016-05-03
JP2014122923A (ja) 2014-07-03
US11071770B2 (en) 2021-07-27
RU2009145695A (ru) 2011-06-20
AU2008251822B2 (en) 2014-02-06
BRPI0810631A2 (pt) 2017-05-09
MX2009012174A (es) 2010-03-30
CN101743474B (zh) 2015-06-03
JP2010527000A (ja) 2010-08-05
US20140378377A1 (en) 2014-12-25
US20110085976A1 (en) 2011-04-14
JP2020176138A (ja) 2020-10-29
JP6636402B2 (ja) 2020-01-29
US20180028610A1 (en) 2018-02-01
IN2014MN01227A (cg-RX-API-DMAC7.html) 2015-07-03
CA2686959C (en) 2017-06-13
US20190269759A1 (en) 2019-09-05
CN104614510B (zh) 2017-07-04
JP2017026622A (ja) 2017-02-02
JP6978553B2 (ja) 2021-12-08
CN101743474A (zh) 2010-06-16
JP5749490B2 (ja) 2015-07-15
MX348082B (es) 2017-05-25
CA2965208A1 (en) 2008-11-20
US20160263192A1 (en) 2016-09-15
EP2153228A4 (en) 2010-08-04
EP2153228A1 (en) 2010-02-17
US9757429B2 (en) 2017-09-12
JP2019010123A (ja) 2019-01-24
CA2686959A1 (en) 2008-11-20
US8628929B2 (en) 2014-01-14

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