CA2965189C - A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens - Google Patents

A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens Download PDF

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Publication number
CA2965189C
CA2965189C CA2965189A CA2965189A CA2965189C CA 2965189 C CA2965189 C CA 2965189C CA 2965189 A CA2965189 A CA 2965189A CA 2965189 A CA2965189 A CA 2965189A CA 2965189 C CA2965189 C CA 2965189C
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CA
Canada
Prior art keywords
pbc
kelch
autoantibody
autoantibodies
elisa
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CA2965189A
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English (en)
French (fr)
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CA2965189A1 (en
Inventor
Mark J. Lim
Heather P. OSTENDORFF
Kenneth J. Rothschild
Donald B. Bloch
Original Assignee
General Hospital Corp
Ambergen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43857083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2965189(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by General Hospital Corp, Ambergen Inc filed Critical General Hospital Corp
Publication of CA2965189A1 publication Critical patent/CA2965189A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2965189A 2009-10-05 2010-10-05 A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens Active CA2965189C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24876809P 2009-10-05 2009-10-05
US61/248768 2009-10-05
CA2776688A CA2776688C (en) 2009-10-05 2010-10-05 A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2776688A Division CA2776688C (en) 2009-10-05 2010-10-05 A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens

Publications (2)

Publication Number Publication Date
CA2965189A1 CA2965189A1 (en) 2011-04-14
CA2965189C true CA2965189C (en) 2020-06-30

Family

ID=43857083

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2965189A Active CA2965189C (en) 2009-10-05 2010-10-05 A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens
CA2776688A Active CA2776688C (en) 2009-10-05 2010-10-05 A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2776688A Active CA2776688C (en) 2009-10-05 2010-10-05 A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens

Country Status (7)

Country Link
US (4) US8852956B2 (https=)
EP (2) EP2486407B1 (https=)
JP (2) JP5710623B2 (https=)
AU (2) AU2010303628B2 (https=)
CA (2) CA2965189C (https=)
ES (2) ES2681839T3 (https=)
WO (1) WO2011044125A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011044125A1 (en) * 2009-10-05 2011-04-14 Ambergen, Inc. A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens
CN104292323B (zh) * 2012-03-23 2017-04-05 中国医学科学院北京协和医院 原发性胆汁性肝硬化特异性自身抗原及其应用
CN104292322A (zh) * 2012-03-23 2015-01-21 中国医学科学院北京协和医院 原发性胆汁性肝硬化特异性自身抗原及其应用
CN102627695B (zh) * 2012-03-23 2014-10-22 中国医学科学院北京协和医院 原发性胆汁性肝硬化特异性自身抗原及其应用
EP3938787B1 (en) * 2019-03-15 2025-12-31 CZ Biohub SF, LLC AUTOANTBODIES USED AS A BIOMARKER FOR PARANEOPLICAL ENCEPHALITIS ASSOCIATED WITH TESTICULAR CANCER
AU2022206267B2 (en) * 2021-01-08 2025-11-20 Inova Diagnostics, Inc. Compositions and methods for diagnosing primary biliary cirrhosis
CN113009148A (zh) * 2021-02-10 2021-06-22 中国医学科学院北京协和医院 用于诊断抗sp100抗体阳性与阴性pbc患者的糖链标志物及其用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
CA1341231C (en) * 1986-12-16 2001-05-15 Ross Leon Coppel Primary biliary cirrhosis autoantigen
JPH03291568A (ja) * 1990-04-09 1991-12-20 Igaku Seibutsugaku Kenkyusho:Kk 抗ミトコンドリアｍ↓２抗体の検出用試薬及び測定法
JP3472048B2 (ja) * 1995-10-09 2003-12-02 鐘淵化学工業株式会社 自己免疫疾患の診断薬
CA2256684A1 (en) * 1996-06-24 1997-12-31 Patrick Leung Recombinant fusion protein comprising pdc-e2, bcoadc-e2, and ogdc-e2 and uses thereof
JPH1138008A (ja) * 1997-07-16 1999-02-12 Sumitomo Electric Ind Ltd 自己抗体の検出方法および検出試薬
US7087717B2 (en) * 2000-07-24 2006-08-08 The General Hospital Corporation Sp110, a polypeptide component of the nuclear body
US20040221327A1 (en) * 2001-03-27 2004-11-04 Gershwin M. Eric Antibodies against autoantigens of primary billary cirrhosis and methods of making and using them
US20070281911A1 (en) * 2004-01-21 2007-12-06 Gilead Sciences Inc. Use of Adefovir or Tenofovir for Inhibiting Mmtv-Like Viruses Involved in Breast Cancer and Primary Biliary Cirrhosis
JP2006071409A (ja) * 2004-09-01 2006-03-16 Kansai Tlo Kk シェーグレン症候群診断キット
WO2007043103A1 (ja) * 2005-09-30 2007-04-19 Kansai Technology Licensing Organization Co., Ltd. シェーグレン症候群診断法及び診断キット
JP2007245505A (ja) 2006-03-15 2007-09-27 Fujifilm Corp 平版印刷版原版、平版印刷版およびその作製方法
US20090047689A1 (en) * 2007-06-20 2009-02-19 John Kolman Autoantigen biomarkers for early diagnosis of lung adenocarcinoma
JP5471724B2 (ja) 2009-09-30 2014-04-16 大日本印刷株式会社 化粧シート
WO2011044125A1 (en) * 2009-10-05 2011-04-14 Ambergen, Inc. A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens
JP2012206482A (ja) 2011-03-30 2012-10-25 Daikyonishikawa Corp 樹脂成形品の組付け構造

Also Published As

Publication number Publication date
JP2015143695A (ja) 2015-08-06
JP2013506837A (ja) 2013-02-28
AU2010303628A1 (en) 2012-04-12
CA2776688A1 (en) 2011-04-14
US11885802B2 (en) 2024-01-30
EP3012631A1 (en) 2016-04-27
US20150057170A1 (en) 2015-02-26
US20240159749A1 (en) 2024-05-16
WO2011044125A1 (en) 2011-04-14
EP2486407A4 (en) 2013-04-10
WO2011044125A8 (en) 2012-09-13
EP2486407B1 (en) 2016-02-10
EP3012631B1 (en) 2018-05-23
CA2776688C (en) 2017-06-20
ES2681839T3 (es) 2018-09-17
AU2015238816A1 (en) 2015-10-29
AU2010303628B2 (en) 2015-07-09
JP6012794B2 (ja) 2016-10-25
EP2486407A1 (en) 2012-08-15
ES2566762T3 (es) 2016-04-15
US20120244562A1 (en) 2012-09-27
US20170307607A1 (en) 2017-10-26
JP5710623B2 (ja) 2015-04-30
US8852956B2 (en) 2014-10-07
AU2015238816B2 (en) 2017-10-05
CA2965189A1 (en) 2011-04-14

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