CA2965151A1 - Serpin fusion polypeptides and methods of use thereof - Google Patents
Serpin fusion polypeptides and methods of use thereof Download PDFInfo
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- CA2965151A1 CA2965151A1 CA2965151A CA2965151A CA2965151A1 CA 2965151 A1 CA2965151 A1 CA 2965151A1 CA 2965151 A CA2965151 A CA 2965151A CA 2965151 A CA2965151 A CA 2965151A CA 2965151 A1 CA2965151 A1 CA 2965151A1
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Classifications
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Landscapes
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| US14/524,832 US10400029B2 (en) | 2011-06-28 | 2014-10-27 | Serpin fusion polypeptides and methods of use thereof |
| PCT/US2015/057533 WO2016069574A1 (en) | 2014-10-27 | 2015-10-27 | Serpin fusion polypeptides and methods of use thereof |
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| WO2020092448A1 (en) * | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| WO2020097946A1 (zh) * | 2018-11-18 | 2020-05-22 | 杭州博虎生物科技有限公司 | 一种重组人白细胞介素10融合蛋白及其应用 |
| CN112315897A (zh) * | 2020-11-04 | 2021-02-05 | 深圳前海鹰岗生物科技有限公司 | 一种抑制细胞炎症反应释放治疗痛风急性发作的聚合物微针及制备方法 |
| WO2022133521A1 (en) * | 2020-12-21 | 2022-06-30 | Macquarie University | Treatment of glaucoma |
| GB202102258D0 (en) | 2021-02-17 | 2021-03-31 | Arecor Ltd | Novel composition |
| AU2022230745A1 (en) * | 2021-03-03 | 2023-08-17 | Formycon Ag | Formulations of ace2 fc fusion proteins |
| CN113325181A (zh) * | 2021-04-25 | 2021-08-31 | 苏州市立医院(北区) | 丝氨酸蛋白酶抑制剂在用于脓毒症早期预警的标志物中的应用 |
| CN114874333A (zh) * | 2021-10-18 | 2022-08-09 | 深圳科兴药业有限公司 | 一种生长激素融合蛋白及其应用 |
| WO2023225513A1 (en) | 2022-05-16 | 2023-11-23 | Inhibrx, Inc. | Effective dosage of recombinant serpin-fc fusion protein for use in a method of treating aat deficiency in a subject |
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| WO2000052160A1 (en) * | 1999-03-01 | 2000-09-08 | Human Genome Sciences, Inc. | Human serpin proteins |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7217797B2 (en) * | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| CN101724022A (zh) * | 2003-07-18 | 2010-06-09 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂 |
| DK2520654T3 (en) * | 2003-08-26 | 2017-05-01 | Univ Colorado Regents | Inhibitors of serine protease activity and their use in methods and compositions for the treatment of bacterial infections |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| EP2325206B1 (en) * | 2004-11-12 | 2014-03-19 | Xencor, Inc. | Fc variants with altered binding to fcrn |
| US7678890B2 (en) * | 2005-07-22 | 2010-03-16 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
| CA2618951A1 (en) * | 2005-08-12 | 2007-02-22 | Schering Corporation | Mcp1 fusions |
| CA2729012A1 (en) * | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| SG10201407908VA (en) * | 2008-12-19 | 2015-01-29 | Macrogenics Inc | Covalent diabodies and uses thereof |
| JP6012624B2 (ja) * | 2010-12-23 | 2016-10-25 | ヤンセン バイオテツク，インコーポレーテツド | 活性プロテアーゼ耐性抗体Ｆｃ突然変異体 |
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| MX356433B (es) * | 2011-06-28 | 2018-05-29 | Inhibrx Lp | Polipéptidos de fusión con domino de proteína ácida del suero, y métodos de uso de los mismos. |
| CA2839619C (en) * | 2011-06-28 | 2021-11-16 | Inhibrx Llc | Serpin fusion polypeptides and methods of use thereof |
| WO2013106589A1 (en) * | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| US20140051834A1 (en) * | 2012-06-21 | 2014-02-20 | Hoffmann-La Roche, Inc. | Incretin Receptor Ligand Polypeptide Fc-Region Fusion Polypeptides And Conjugates With Altered Fc-Effector Function |
| CN104411718B (zh) * | 2012-06-27 | 2018-04-24 | 弗·哈夫曼-拉罗切有限公司 | 用于制备包含特异性结合靶的至少一种结合实体的抗体Fc区缀合物的方法及其用途 |
| ES2602030T3 (es) * | 2012-08-02 | 2017-02-17 | F. Hoffmann-La Roche Ag | Método para producir RFc solubles como fusión de Fc con la región Fc de inmunoglobulina inerte y usos de los mismos |
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| KR20240005109A (ko) | 2024-01-11 |
| IL308589A (en) | 2024-01-01 |
| JP6737781B2 (ja) | 2020-08-12 |
| RU2746550C2 (ru) | 2021-04-15 |
| CN107206257A (zh) | 2017-09-26 |
| JP2017537888A (ja) | 2017-12-21 |
| RU2017118325A (ru) | 2018-11-29 |
| SG10201903142RA (en) | 2019-05-30 |
| IL251799A0 (en) | 2017-06-29 |
| AU2015339507B2 (en) | 2021-07-01 |
| MX2017005467A (es) | 2017-11-30 |
| RU2017118325A3 (es) | 2019-03-21 |
| MX2021012047A (es) | 2021-11-03 |
| BR112017008525A2 (pt) | 2018-01-30 |
| EP3212290A1 (en) | 2017-09-06 |
| SG11201703390SA (en) | 2017-05-30 |
| WO2016069574A1 (en) | 2016-05-06 |
| UA127305C2 (uk) | 2023-07-19 |
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