CA2965151A1 - Polypeptides de fusion de serpine et leurs procedes d'utilisation - Google Patents
Polypeptides de fusion de serpine et leurs procedes d'utilisation Download PDFInfo
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- CA2965151A1 CA2965151A1 CA2965151A CA2965151A CA2965151A1 CA 2965151 A1 CA2965151 A1 CA 2965151A1 CA 2965151 A CA2965151 A CA 2965151A CA 2965151 A CA2965151 A CA 2965151A CA 2965151 A1 CA2965151 A1 CA 2965151A1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Biochemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
L'invention concerne des molécules, en particulier des polypeptides, plus particulièrement des protéines de fusion qui comprennent un polypeptide de serpine ou une séquence d'acides aminés qui est dérivée d'une serpine, et un second polypeptide comprenant au moins l'un des éléments suivants : un polypeptide Fc ou une séquence d'acides aminés qui est dérivée d'un polypeptide Fc ; un polypeptide de ciblage de cytokines ou une séquence dérivée d'un polypeptide de ciblage de cytokines ; un polypeptide contenant un domaine WAP ou une séquence dérivée d'un polypeptide contenant un domaine WAP ; et un polypeptide d'albumine ou une séquence d'acides aminés qui est dérivée d'un polypeptide de sérum-albumine. La présente invention concerne également des procédés d'utilisation de telles molécules dans une large gamme d'indications thérapeutiques et diagnostiques, ainsi que des procédés de production de telles molécules.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/524,832 US10400029B2 (en) | 2011-06-28 | 2014-10-27 | Serpin fusion polypeptides and methods of use thereof |
| US14/524,832 | 2014-10-27 | ||
| PCT/US2015/057533 WO2016069574A1 (fr) | 2014-10-27 | 2015-10-27 | Polypeptides de fusion de serpine et leurs procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2965151A1 true CA2965151A1 (fr) | 2016-05-06 |
Family
ID=55858243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2965151A Pending CA2965151A1 (fr) | 2014-10-27 | 2015-10-27 | Polypeptides de fusion de serpine et leurs procedes d'utilisation |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP3212290A4 (fr) |
| JP (2) | JP6737781B2 (fr) |
| KR (2) | KR20240005109A (fr) |
| CN (2) | CN107206257A (fr) |
| AU (2) | AU2015339507B2 (fr) |
| BR (1) | BR112017008525A2 (fr) |
| CA (1) | CA2965151A1 (fr) |
| HK (1) | HK1244460A1 (fr) |
| IL (2) | IL308589A (fr) |
| MX (2) | MX2017005467A (fr) |
| RU (1) | RU2746550C2 (fr) |
| SG (2) | SG10201903142RA (fr) |
| UA (1) | UA127305C2 (fr) |
| WO (1) | WO2016069574A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020092448A1 (fr) * | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions et méthodes pour les dérèglements de l'alpha-1 antitrypsine |
| WO2020097946A1 (fr) * | 2018-11-18 | 2020-05-22 | 杭州博虎生物科技有限公司 | Protéine de fusion de l'interleukine-10 humaine recombinée et utilisation associée |
| CN112315897A (zh) * | 2020-11-04 | 2021-02-05 | 深圳前海鹰岗生物科技有限公司 | 一种抑制细胞炎症反应释放治疗痛风急性发作的聚合物微针及制备方法 |
| US20240067703A1 (en) * | 2020-12-21 | 2024-02-29 | Macquarie University | Treatment of glaucoma |
| GB202102258D0 (en) | 2021-02-17 | 2021-03-31 | Arecor Ltd | Novel composition |
| CA3205815A1 (fr) * | 2021-03-03 | 2022-09-09 | Alwin REITER | Formulations de proteines de fusion ace2 fc |
| CN113325181A (zh) * | 2021-04-25 | 2021-08-31 | 苏州市立医院(北区) | 丝氨酸蛋白酶抑制剂在用于脓毒症早期预警的标志物中的应用 |
| CN114874333A (zh) * | 2021-10-18 | 2022-08-09 | 深圳科兴药业有限公司 | 一种生长激素融合蛋白及其应用 |
| US20230364208A1 (en) | 2022-05-16 | 2023-11-16 | Inhibrx, Inc. | Effective dosage of recombinant serpin-fc fusion protein for use in a method of treating aat deficiency in a subject |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3609300A (en) * | 1999-03-01 | 2000-09-21 | Human Genome Sciences, Inc. | Human serpin proteins |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7217797B2 (en) * | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| EP1646642A2 (fr) * | 2003-07-18 | 2006-04-19 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de serines proteases, en particulier de la protease ns3-ns4a du vhc |
| PL2520654T3 (pl) * | 2003-08-26 | 2017-08-31 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| EP2332985A3 (fr) * | 2004-11-12 | 2012-01-25 | Xencor, Inc. | Variants de Fc avec une liaison altérée à fcrn |
| DE602006010874D1 (de) * | 2005-07-22 | 2010-01-14 | Five Prime Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von krankheiten mit fgfr-fusionsproteinen |
| CA2618951A1 (fr) * | 2005-08-12 | 2007-02-22 | Schering Corporation | Fusions de mcp1 |
| EP2307456B1 (fr) * | 2008-06-27 | 2014-10-15 | Amgen Inc. | Inhibition de l ang-2 pour traiter la sclérose en plaques |
| RU2593720C2 (ru) * | 2008-12-19 | 2016-08-10 | Макродженикс, Инк. | Ковалентные диантитела и их применение |
| PT2654780T (pt) * | 2010-12-23 | 2017-04-06 | Janssen Biotech Inc | Mutantes ativos de fc de anticorpos resistentes a proteases |
| ES2692268T3 (es) * | 2011-03-29 | 2018-12-03 | Roche Glycart Ag | Variantes de Fc de anticuerpo |
| IN2013MN02441A (fr) * | 2011-06-28 | 2015-06-12 | Inhibrx Llc | |
| KR20140068861A (ko) * | 2011-06-28 | 2014-06-09 | 인히브릭스 엘엘씨 | Wap 도메인 융합 폴리펩티드 및 이의 이용 방법 |
| KR20140137347A (ko) * | 2012-01-10 | 2014-12-02 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| EP2863954A1 (fr) * | 2012-06-21 | 2015-04-29 | Indiana University Research and Technology Corporation | Polypeptides de fusion de région fc de polypeptide ligand du récepteur d'incrétine et conjugués à fonction effectrice fc modifiée |
| EP2867254B1 (fr) * | 2012-06-27 | 2017-10-25 | F. Hoffmann-La Roche AG | Procédé de fabrication de conjugués de régions fc comprenant au moins une portion capable de se lier de manière spécifique à une cible et utilisations desdits conjugués |
| ES2602030T3 (es) * | 2012-08-02 | 2017-02-17 | F. Hoffmann-La Roche Ag | Método para producir RFc solubles como fusión de Fc con la región Fc de inmunoglobulina inerte y usos de los mismos |
| CA2893359C (fr) * | 2012-12-05 | 2021-12-28 | Strategia Therapeutics, Inc. | Polypeptides ameliorant l'expression proteique |
-
2015
- 2015-10-27 MX MX2017005467A patent/MX2017005467A/es unknown
- 2015-10-27 SG SG10201903142RA patent/SG10201903142RA/en unknown
- 2015-10-27 CN CN201580071331.7A patent/CN107206257A/zh active Pending
- 2015-10-27 BR BR112017008525-9A patent/BR112017008525A2/pt active Search and Examination
- 2015-10-27 CA CA2965151A patent/CA2965151A1/fr active Pending
- 2015-10-27 JP JP2017522654A patent/JP6737781B2/ja active Active
- 2015-10-27 IL IL308589A patent/IL308589A/en unknown
- 2015-10-27 CN CN202111439584.9A patent/CN114316068A/zh active Pending
- 2015-10-27 SG SG11201703390SA patent/SG11201703390SA/en unknown
- 2015-10-27 KR KR1020237043666A patent/KR20240005109A/ko active Application Filing
- 2015-10-27 IL IL251799A patent/IL251799B2/en unknown
- 2015-10-27 KR KR1020177014414A patent/KR20170091096A/ko not_active IP Right Cessation
- 2015-10-27 EP EP15854670.5A patent/EP3212290A4/fr active Pending
- 2015-10-27 AU AU2015339507A patent/AU2015339507B2/en active Active
- 2015-10-27 UA UAA201705128A patent/UA127305C2/uk unknown
- 2015-10-27 WO PCT/US2015/057533 patent/WO2016069574A1/fr active Application Filing
- 2015-10-27 RU RU2017118325A patent/RU2746550C2/ru active
-
2017
- 2017-04-26 MX MX2021012047A patent/MX2021012047A/es unknown
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2018
- 2018-03-05 HK HK18103148.5A patent/HK1244460A1/zh unknown
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2020
- 2020-07-16 JP JP2020121953A patent/JP2020180157A/ja active Pending
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2021
- 2021-09-28 AU AU2021240153A patent/AU2021240153A1/en active Pending
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| Publication number | Publication date |
|---|---|
| BR112017008525A2 (pt) | 2018-01-30 |
| JP2020180157A (ja) | 2020-11-05 |
| SG10201903142RA (en) | 2019-05-30 |
| SG11201703390SA (en) | 2017-05-30 |
| IL251799B2 (en) | 2024-04-01 |
| CN107206257A (zh) | 2017-09-26 |
| AU2015339507A1 (en) | 2017-05-11 |
| WO2016069574A1 (fr) | 2016-05-06 |
| EP3212290A4 (fr) | 2019-01-23 |
| CN114316068A (zh) | 2022-04-12 |
| AU2015339507B2 (en) | 2021-07-01 |
| IL308589A (en) | 2024-01-01 |
| HK1244460A1 (zh) | 2018-08-10 |
| UA127305C2 (uk) | 2023-07-19 |
| MX2021012047A (es) | 2021-11-03 |
| RU2746550C2 (ru) | 2021-04-15 |
| AU2021240153A1 (en) | 2021-10-28 |
| JP2017537888A (ja) | 2017-12-21 |
| MX2017005467A (es) | 2017-11-30 |
| EP3212290A1 (fr) | 2017-09-06 |
| KR20170091096A (ko) | 2017-08-08 |
| IL251799A0 (en) | 2017-06-29 |
| RU2017118325A3 (fr) | 2019-03-21 |
| KR20240005109A (ko) | 2024-01-11 |
| IL251799B1 (en) | 2023-12-01 |
| JP6737781B2 (ja) | 2020-08-12 |
| RU2017118325A (ru) | 2018-11-29 |
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