CA2963991A1 - Bispecific molecules comprising an hiv-1 envelope targeting arm - Google Patents
Bispecific molecules comprising an hiv-1 envelope targeting arm Download PDFInfo
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- CA2963991A1 CA2963991A1 CA2963991A CA2963991A CA2963991A1 CA 2963991 A1 CA2963991 A1 CA 2963991A1 CA 2963991 A CA2963991 A CA 2963991A CA 2963991 A CA2963991 A CA 2963991A CA 2963991 A1 CA2963991 A1 CA 2963991A1
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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| US201562206586P | 2015-08-18 | 2015-08-18 | |
| US62/206,586 | 2015-08-18 | ||
| PCT/US2015/053027 WO2016054101A1 (en) | 2014-09-29 | 2015-09-29 | Bispecific molecules comprising an hiv-1 envelope targeting arm |
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| CA2963991A1 true CA2963991A1 (en) | 2016-04-07 |
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| US10633443B2 (en) * | 2014-09-26 | 2020-04-28 | Macrogenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD19 and CD3, and uses thereof |
| CA2963991A1 (en) | 2014-09-29 | 2016-04-07 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| CN108367069B (zh) | 2015-12-14 | 2022-08-23 | 宏观基因有限公司 | 对于pd-1和ctla-4具有免疫反应性的双特异性分子及其使用方法 |
| BR112018075198A2 (pt) | 2016-06-07 | 2019-03-19 | Macrogenics, Inc. | método para o tratamento de câncer ou uma doença associada a patógeno, composição farmacêutica, e kit |
| WO2018053328A1 (en) * | 2016-09-16 | 2018-03-22 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| CN108728463A (zh) * | 2017-04-14 | 2018-11-02 | 深圳新诺微环生物科技有限公司 | 一种表达IgG抗体的微环DNA载体及其制备方法和应用 |
| CN108728465A (zh) * | 2017-04-14 | 2018-11-02 | 深圳新诺微环生物科技有限公司 | 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用 |
| SG11202005557TA (en) * | 2017-12-12 | 2020-07-29 | Macrogenics Inc | Bispecific cd 16-binding molecules and their use in the treatment of disease |
| MX2020008489A (es) | 2018-02-15 | 2020-09-25 | Macrogenics Inc | Dominios de union a cd3 variantes y su uso en terapias de combinacion para el tratamiento de enfermedades. |
| AU2019269383A1 (en) * | 2018-05-18 | 2020-12-10 | Duke University | Optimized GP41-binding molecules and uses thereof |
| JP2023545135A (ja) * | 2020-10-12 | 2023-10-26 | グレフェックス， インコーポレイテッド | ＳＡＲＳ－ＣｏＶタンパク質発現細胞に対するＴ細胞応答を標的にする抗体コンストラクト、それらの設計および使用 |
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2015
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- 2015-09-29 WO PCT/US2015/053027 patent/WO2016054101A1/en not_active Ceased
- 2015-09-29 JP JP2017536234A patent/JP6932639B2/ja not_active Expired - Fee Related
- 2015-09-29 AU AU2015323860A patent/AU2015323860B2/en not_active Ceased
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| EP3201227A4 (en) | 2018-04-18 |
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| WO2016054101A1 (en) | 2016-04-07 |
| ZA201702235B (en) | 2021-09-29 |
| AU2015323860B2 (en) | 2021-05-27 |
| AU2015323860A1 (en) | 2017-05-11 |
| US12173051B2 (en) | 2024-12-24 |
| IL251437B (en) | 2021-02-28 |
| BR112017006515A8 (pt) | 2018-02-27 |
| JP6932639B2 (ja) | 2021-09-08 |
| IL251437A0 (en) | 2017-05-29 |
| JP2017534296A (ja) | 2017-11-24 |
| CN107108721B (zh) | 2021-09-07 |
| US20200354439A1 (en) | 2020-11-12 |
| MX2017004076A (es) | 2017-07-04 |
| MX386297B (es) | 2025-03-18 |
| SG11201702544WA (en) | 2017-04-27 |
| CN107108721A (zh) | 2017-08-29 |
| BR112017006515A2 (pt) | 2017-12-19 |
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