CA2963582C - Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal - Google Patents

Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal Download PDF

Info

Publication number
CA2963582C
CA2963582C CA2963582A CA2963582A CA2963582C CA 2963582 C CA2963582 C CA 2963582C CA 2963582 A CA2963582 A CA 2963582A CA 2963582 A CA2963582 A CA 2963582A CA 2963582 C CA2963582 C CA 2963582C
Authority
CA
Canada
Prior art keywords
polymer
units
methacrylates
polyoxyethylene
methacrylamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2963582A
Other languages
English (en)
Other versions
CA2963582A1 (fr
Inventor
Zdenka Sedlakova
Lenka POLAKOVA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USTAV MAKROMOLEKULARNI CHEMIE AV CR VVI
Original Assignee
USTAV MAKROMOLEKULARNI CHEMIE AV CR VVI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USTAV MAKROMOLEKULARNI CHEMIE AV CR VVI filed Critical USTAV MAKROMOLEKULARNI CHEMIE AV CR VVI
Publication of CA2963582A1 publication Critical patent/CA2963582A1/fr
Application granted granted Critical
Publication of CA2963582C publication Critical patent/CA2963582C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une préparation pour une utilisation par voie orale pour prévenir et traiter des affections inflammatoires du tractus gastro-intestinal, ladite préparation contenant un polymère hydrophile, biocompatible et muco-adhérent contenant : - au moins un type d'unités structurelles A choisies dans un groupe comportant des unités dérivées d'acides acrylique et méthacrylique et leurs sels, de méthacrylates et d'acrylates d'hydroxyalkyle, de méthacrylamides et d'acrylamides d'hydroxyalkyle, de méthacrylates et d'acrylates de N,N-dialkylaminoalkyle, de méthacrylamides et d'acrylamides de N,N-dialkylaminoalkyle, de N-vinyle-2-pyrrolidone et des mélanges de ceux-ci ; - au moins un type d'unités structurelles B choisies dans un groupe comprenant des unités dérivées de méthacrylates et d'acrylates (polyoxyéthylène) à terminaison hydroxy, de méthacrylates et d'acrylates (polyoxyéthylène) à terminaison alkyloxy, de méthacrylamides et d'acrylamides (polyoxyéthylène) à terminaison hydroxy, de méthacrylamides et d'acrylamides (polyoxyéthylène) à terminaison alkyloxy et des mélanges de ceux-ci ; - au moins un type d'unités structurelles C dérivées d'amines à encombrement stérique.
CA2963582A 2014-11-28 2015-11-20 Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal Active CA2963582C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZPV2014-825 2014-11-28
CZ2014-825A CZ2014825A3 (cs) 2014-11-28 2014-11-28 Přípravek pro orální použití
PCT/CZ2015/050011 WO2016082808A1 (fr) 2014-11-28 2015-11-20 Préparation orale

Publications (2)

Publication Number Publication Date
CA2963582A1 CA2963582A1 (fr) 2016-06-02
CA2963582C true CA2963582C (fr) 2017-12-05

Family

ID=54054181

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2963582A Active CA2963582C (fr) 2014-11-28 2015-11-20 Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal

Country Status (3)

Country Link
CA (1) CA2963582C (fr)
CZ (1) CZ2014825A3 (fr)
WO (1) WO2016082808A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ308047B6 (cs) * 2018-07-17 2019-11-20 Ústav makromolekulární chemie AV ČR, v. v. i. Tekutý krycí přípravek pro ošetření ran

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ293419B6 (cs) * 1997-12-03 2004-04-14 Ústav Makromolekulární Chemie Av Čr Přípravek k prevenci a hojení zánětlivých onemocnění
JP5737705B2 (ja) * 2008-05-02 2015-06-17 国立大学法人 筑波大学 高分子化環状ニトロキシドラジカル化合物およびその使用
CZ2008490A3 (cs) * 2008-08-15 2010-02-24 Labský@Jirí Synergický vliv benzofenonu a stericky stínených aminu pri lécení povrchových poranení
JP5850518B2 (ja) * 2010-11-22 2016-02-03 国立大学法人 筑波大学 高分子化環状ニトロキシドラジカル化合物の潰瘍性消化管の炎症の処置剤
JP2013173689A (ja) * 2012-02-24 2013-09-05 Univ Of Tsukuba 高分子化ニトロキシドラジカル化合物と非ステロイド性抗炎症薬の複合体

Also Published As

Publication number Publication date
WO2016082808A1 (fr) 2016-06-02
CZ305391B6 (cs) 2015-08-26
CZ2014825A3 (cs) 2015-08-26
CA2963582A1 (fr) 2016-06-02

Similar Documents

Publication Publication Date Title
Duong et al. The use of nanoparticles to deliver nitric oxide to hepatic stellate cells for treating liver fibrosis and portal hypertension
Foss et al. Development of acrylic-based copolymers for oral insulin delivery
Bailly et al. Poly (N-vinylpyrrolidone)-block-poly (vinyl acetate) as a drug delivery vehicle for hydrophobic drugs
US11123363B2 (en) Potassium-binding agents for treating hypertension and hyperkalemia
CA2175479A1 (fr) Systemes d'administration de medicaments
JP2000517356A (ja) 併発胆汁酸吸着作用を有する高分子量胆汁酸吸収阻害剤
Singh et al. Dietary fiber tragacanth gum based hydrogels for use in drug delivery applications
Singh et al. Development of novel hydrogels by functionalization of sterculia gum for use in anti-ulcer drug delivery
CA2963582C (fr) Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal
Poláková et al. SHARP hydrogel for the treatment of inflammatory bowel disease
JP4298915B2 (ja) 炎症疾患の予防および治療のための製剤
Deng et al. Metal polyphenol network/cerium oxide artificial enzymes therapeutic nanoplatform for MRI/CT-aided intestinal inflammation management
Tuesca et al. Complexation hydrogels for oral insulin delivery: effects of polymer dosing on in vivo efficacy
Suhail et al. Fabrication, characterization and toxicological evaluation of polyethylene glycol/sodium polystyrene sulfonate hydrogels for controlled delivery of Acetaminophen
Taktak Rapid Deswelling of PDMAEMA Hydrogel in Response to pH and Temperature Changes and Its Application in Controlled Drug Delivery
JP2021020876A (ja) がん療法用のｔ−ＰＡ含有ポリマー組成物
Das et al. Modified hydroxypropyl methyl cellulose: efficient matrix for controlled release of 5-amino salicylic acid
Suhail et al. In-vitro and in-vivo evaluation of biocompatible polymeric microgels for pH-driven delivery of Ketorolac tromethamine
Bajpai et al. Dynamic release of riboflavin from a colon-targeted delivery device: an in vitro study
CN113801276A (zh) 一种用于肿瘤放化疗协同治疗的纳米药物及其制备方法和应用
Bajpai et al. Controlled release of an anti-malarial drug from a pH-sensitive poly (methacrylamide-co-methacrylic acid) hydrogel system
KR101722827B1 (ko) 하이드록시 라디칼 생성유도 고분자 항암제 및 그의 제조방법
US20220332876A1 (en) Hydrophilic-hydrophobic copolymer carrying short chain fatty acid ester
Khan et al. Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design
Geng et al. Regulation of rheumatoid arthritis microenvironment via a self-healing injectable hydrogel for improved inflammation elimination and bone repair

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170404