CA2959478C - Dihydro- or tetrahydroquinolin-2-0ne derivatives and their use for the treatment of tuberculosis - Google Patents
Dihydro- or tetrahydroquinolin-2-0ne derivatives and their use for the treatment of tuberculosis Download PDFInfo
- Publication number
- CA2959478C CA2959478C CA2959478A CA2959478A CA2959478C CA 2959478 C CA2959478 C CA 2959478C CA 2959478 A CA2959478 A CA 2959478A CA 2959478 A CA2959478 A CA 2959478A CA 2959478 C CA2959478 C CA 2959478C
- Authority
- CA
- Canada
- Prior art keywords
- fluoro
- compound
- chloro
- dihydroquinolin
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014174528 | 2014-08-28 | ||
| JP2014-174528 | 2014-08-28 | ||
| PCT/JP2015/004371 WO2016031255A1 (en) | 2014-08-28 | 2015-08-28 | Heterobicyclic compounds and their use for the treatment of tuberculosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2959478A1 CA2959478A1 (en) | 2016-03-03 |
| CA2959478C true CA2959478C (en) | 2023-09-26 |
Family
ID=54105947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2959478A Active CA2959478C (en) | 2014-08-28 | 2015-08-28 | Dihydro- or tetrahydroquinolin-2-0ne derivatives and their use for the treatment of tuberculosis |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US10053446B2 (https=) |
| EP (1) | EP3186240B9 (https=) |
| JP (1) | JP6625612B2 (https=) |
| KR (1) | KR102418413B1 (https=) |
| CN (1) | CN106795117B (https=) |
| AP (1) | AP2017009788A0 (https=) |
| AR (1) | AR101704A1 (https=) |
| AU (1) | AU2015307873B2 (https=) |
| BR (1) | BR112017003231B1 (https=) |
| CA (1) | CA2959478C (https=) |
| CY (1) | CY1122286T1 (https=) |
| DK (1) | DK3186240T3 (https=) |
| EA (1) | EA038414B1 (https=) |
| ES (1) | ES2743788T3 (https=) |
| HR (1) | HRP20191486T2 (https=) |
| HU (1) | HUE045025T2 (https=) |
| IL (1) | IL250484B (https=) |
| LT (1) | LT3186240T (https=) |
| MX (1) | MX2017002312A (https=) |
| MY (1) | MY189098A (https=) |
| NZ (1) | NZ729064A (https=) |
| PH (1) | PH12017500290B1 (https=) |
| PL (1) | PL3186240T3 (https=) |
| PT (1) | PT3186240T (https=) |
| SG (1) | SG11201700882XA (https=) |
| SI (1) | SI3186240T1 (https=) |
| TW (1) | TWI687409B (https=) |
| WO (1) | WO2016031255A1 (https=) |
| ZA (1) | ZA201700916B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI687409B (zh) * | 2014-08-28 | 2020-03-11 | 日商大塚製藥股份有限公司 | 稠合雜環化合物 |
| JP6905506B2 (ja) * | 2016-02-26 | 2021-07-21 | 大塚製薬株式会社 | ピペリジン誘導体 |
| WO2019239382A1 (en) | 2018-06-15 | 2019-12-19 | Cadila Healthcare Limited | Condensed azaheteroaryl compounds having antibacterial activity against tuberculosis bacteria |
| JP2023085582A (ja) * | 2020-05-11 | 2023-06-21 | 大塚製薬株式会社 | ジヒドロキノリノン化合物の共結晶 |
| WO2022039506A1 (ko) * | 2020-08-19 | 2022-02-24 | 주식회사 미토이뮨테라퓨틱스 | Ｍabc-r 감염에 의한 병적 염증 치료제로서의 미토콘드리아 표적 항산화제 |
| CN116102537B (zh) * | 2021-11-10 | 2024-10-01 | 四川大学 | 一种喹啉酮类衍生物及其制备方法和用途 |
| CN116589448B (zh) * | 2023-04-24 | 2025-10-28 | 西南交通大学 | 一种3,4-二氢喹啉酮衍生物及其应用 |
| WO2025183016A1 (ja) * | 2024-02-26 | 2025-09-04 | 大塚製薬株式会社 | Ｑｕａｂｏｄｅｐｉｓｔａｔ含有組成物 |
| WO2025183017A1 (ja) * | 2024-02-26 | 2025-09-04 | 大塚製薬株式会社 | Ｑｕａｂｏｄｅｐｉｓｔａｔ含有組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2608788B2 (ja) * | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
| US5668127A (en) | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
| TWI347946B (en) | 2002-10-11 | 2011-09-01 | Otsuka Pharma Co Ltd | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound |
| GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| WO2005042542A1 (en) | 2003-10-31 | 2005-05-12 | Otsuka Pharmaceutical Co., Ltd. | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis |
| JP4761756B2 (ja) * | 2003-10-31 | 2011-08-31 | 大塚製薬株式会社 | ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物 |
| UA91822C2 (ru) * | 2003-10-31 | 2010-09-10 | Оцука Фармасьютикел Ко., Лтд. | СОЕДИНЕНИЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА ДЛЯ ЛЕЧЕНИЯ ТУБЕРКУЛЕЗА |
| RS56037B1 (sr) * | 2004-06-24 | 2017-09-29 | Vertex Pharma | Modulatori atp-vezujućih kasetnih transportera |
| EP2520567A3 (en) | 2006-02-23 | 2012-12-12 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle derivatives substituted with cyclic group |
| GB0812648D0 (en) | 2008-07-10 | 2008-08-20 | Prosidion Ltd | Compounds |
| WO2010045987A1 (en) * | 2008-10-23 | 2010-04-29 | Glaxo Group Limited | Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials |
| ES2530266T3 (es) | 2009-07-31 | 2015-02-27 | Global Alliance For Tb Drug Development | Análogos de nitroimidazooxazina y sus usos |
| JP5916739B2 (ja) | 2011-04-15 | 2016-05-11 | 大塚製薬株式会社 | ６，７−ジヒドロイミダゾ［２，１−ｂ］［１，３］オキサジン化合物 |
| TWI687409B (zh) * | 2014-08-28 | 2020-03-11 | 日商大塚製藥股份有限公司 | 稠合雜環化合物 |
| JP6905506B2 (ja) * | 2016-02-26 | 2021-07-21 | 大塚製薬株式会社 | ピペリジン誘導体 |
-
2015
- 2015-08-27 TW TW104128109A patent/TWI687409B/zh active
- 2015-08-27 AR ARP150102746A patent/AR101704A1/es active IP Right Grant
- 2015-08-28 AP AP2017009788A patent/AP2017009788A0/en unknown
- 2015-08-28 US US15/506,887 patent/US10053446B2/en active Active
- 2015-08-28 MY MYPI2017700649A patent/MY189098A/en unknown
- 2015-08-28 JP JP2017507903A patent/JP6625612B2/ja active Active
- 2015-08-28 KR KR1020177007855A patent/KR102418413B1/ko active Active
- 2015-08-28 MX MX2017002312A patent/MX2017002312A/es active IP Right Grant
- 2015-08-28 HU HUE15763096A patent/HUE045025T2/hu unknown
- 2015-08-28 SG SG11201700882XA patent/SG11201700882XA/en unknown
- 2015-08-28 HR HRP20191486TT patent/HRP20191486T2/hr unknown
- 2015-08-28 PH PH1/2017/500290A patent/PH12017500290B1/en unknown
- 2015-08-28 EA EA201790464A patent/EA038414B1/ru unknown
- 2015-08-28 LT LTEP15763096.3T patent/LT3186240T/lt unknown
- 2015-08-28 ES ES15763096T patent/ES2743788T3/es active Active
- 2015-08-28 SI SI201530868T patent/SI3186240T1/sl unknown
- 2015-08-28 BR BR112017003231-7A patent/BR112017003231B1/pt active IP Right Grant
- 2015-08-28 CN CN201580045974.4A patent/CN106795117B/zh active Active
- 2015-08-28 PL PL15763096T patent/PL3186240T3/pl unknown
- 2015-08-28 EP EP15763096.3A patent/EP3186240B9/en active Active
- 2015-08-28 DK DK15763096.3T patent/DK3186240T3/da active
- 2015-08-28 AU AU2015307873A patent/AU2015307873B2/en active Active
- 2015-08-28 CA CA2959478A patent/CA2959478C/en active Active
- 2015-08-28 PT PT15763096T patent/PT3186240T/pt unknown
- 2015-08-28 NZ NZ729064A patent/NZ729064A/en unknown
- 2015-08-28 WO PCT/JP2015/004371 patent/WO2016031255A1/en not_active Ceased
-
2017
- 2017-02-06 ZA ZA2017/00916A patent/ZA201700916B/en unknown
- 2017-02-07 IL IL250484A patent/IL250484B/en active IP Right Grant
-
2018
- 2018-07-09 US US16/029,850 patent/US10464926B2/en active Active
-
2019
- 2019-08-26 CY CY20191100906T patent/CY1122286T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20201113 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD Year of fee payment: 9 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 10TH ANNIV.) - STANDARD Year of fee payment: 10 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250702 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250702 |