CA2958801A1 - Methods and materials for assessing homologous recombination deficiency - Google Patents

Methods and materials for assessing homologous recombination deficiency Download PDF

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Publication number
CA2958801A1
CA2958801A1 CA2958801A CA2958801A CA2958801A1 CA 2958801 A1 CA2958801 A1 CA 2958801A1 CA 2958801 A CA2958801 A CA 2958801A CA 2958801 A CA2958801 A CA 2958801A CA 2958801 A1 CA2958801 A1 CA 2958801A1
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regions
indicator
cancer
loh
patient
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CA2958801A
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English (en)
French (fr)
Inventor
Victor Abkevich
Kirsten Timms
Alexander Gutin
Julia Reid
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Myriad Genetics Inc
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Myriad Genetics Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54035301&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2958801(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Myriad Genetics Inc filed Critical Myriad Genetics Inc
Publication of CA2958801A1 publication Critical patent/CA2958801A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Catalysts (AREA)
CA2958801A 2014-08-15 2015-08-17 Methods and materials for assessing homologous recombination deficiency Pending CA2958801A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462037764P 2014-08-15 2014-08-15
US62/037,764 2014-08-15
US201414507412A 2014-10-06 2014-10-06
US14/507,412 2014-10-06
PCT/US2015/045561 WO2016025958A1 (en) 2014-08-15 2015-08-17 Methods and materials for assessing homologous recombination deficiency

Publications (1)

Publication Number Publication Date
CA2958801A1 true CA2958801A1 (en) 2016-02-18

Family

ID=54035301

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2958801A Pending CA2958801A1 (en) 2014-08-15 2015-08-17 Methods and materials for assessing homologous recombination deficiency

Country Status (9)

Country Link
US (4) US10400287B2 (https=)
EP (4) EP3180447B1 (https=)
JP (4) JP6877334B2 (https=)
AU (2) AU2015301390B2 (https=)
CA (1) CA2958801A1 (https=)
DK (3) DK3686288T3 (https=)
ES (3) ES2946251T3 (https=)
PT (1) PT3180447T (https=)
WO (1) WO2016025958A1 (https=)

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EP3423048A4 (en) * 2016-02-29 2019-10-23 Synta Pharmaceuticals Corp. COMBINATION THERAPY FOR THE TREATMENT OF EGG CANCER
WO2017178509A1 (en) * 2016-04-12 2017-10-19 Xentech Methods for predicting sensibility to treatment with parp inhibitors in cancerous patients
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CN108663519A (zh) * 2017-04-21 2018-10-16 江苏希摩生物科技有限公司 快速预测和提高BRCA1/2野生型卵巢癌细胞对Olaparib敏感性的方法
WO2019079255A1 (en) * 2017-10-16 2019-04-25 Board Of Regents Of The University Of Texas System METHODS AND COMPOSITIONS FOR THE USE OF TREX2 AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR CANCER
US10975445B2 (en) 2019-02-12 2021-04-13 Tempus Labs, Inc. Integrated machine-learning framework to estimate homologous recombination deficiency
WO2021011507A1 (en) * 2019-07-12 2021-01-21 Tempus Labs Adaptive order fulfillment and tracking methods and systems
WO2021070039A2 (en) * 2019-10-09 2021-04-15 Immunitybio, Inc. Detecting homologous recombination deficiencies (hrd) in clinical samples
ES2989374T3 (es) 2019-12-10 2024-11-26 Tempus Ai Inc Sistemas y procedimientos para predecir el estado de deficiencia de recombinación homóloga de una muestra
JP7842700B2 (ja) * 2020-05-14 2026-04-08 ガーダント ヘルス， インコーポレイテッド 相同組換え修復欠損の検出
EP3945525A1 (en) 2020-07-27 2022-02-02 Sophia Genetics S.A. Methods for identifying chromosomal spatial instability such as homologous repair deficiency in low coverage next-generation sequencing data
CN112410423B (zh) * 2020-11-03 2021-08-13 南京世和基因生物技术股份有限公司 同源重组缺失的标志物、检测方法以及检测系统
CN112397145A (zh) * 2020-11-19 2021-02-23 河南省肿瘤医院 一种基于芯片检测的hrd评分计算方法
JP7585015B2 (ja) 2020-12-04 2024-11-18 株式会社東芝 核酸構築物のセット、キット、検出方法及び薬剤効果予測方法
US20240026462A1 (en) * 2021-01-10 2024-01-25 Ying Ja CHEN Homologous recombination deficiency determining method and kit thereof
WO2022150063A1 (en) * 2021-01-10 2022-07-14 Act Genomics (Ip) Co., Ltd. Homologous recombination deficiency determining method and kit thereof
CN112820351A (zh) * 2021-03-01 2021-05-18 江苏医联生物科技有限公司 检测肿瘤患者的突变和hrd评分指导用药的方法
CN112980834B (zh) * 2021-04-22 2021-08-17 菁良基因科技(深圳)有限公司 一种同源重组修复缺陷参考品及其制备方法和试剂盒
CN113257346B (zh) * 2021-06-28 2021-10-19 北京橡鑫生物科技有限公司 一种基于低深度WGS评估HRD score的方法
CN113658638B (zh) * 2021-08-20 2022-06-03 江苏先声医学诊断有限公司 一种基于ngs平台的同源重组缺陷的检测方法和质控体系
CN118369439A (zh) * 2021-12-08 2024-07-19 麦利亚德基因公司 用于评估乳腺癌亚型中同源重组缺陷的方法和材料
CN114242170B (zh) * 2021-12-21 2023-05-09 深圳吉因加医学检验实验室 一种同源重组修复缺陷的评估方法、装置和存储介质
CN114283889B (zh) * 2021-12-27 2024-12-10 深圳吉因加医学检验实验室 一种矫正同源重组修复缺陷评分的方法及装置
KR102523938B1 (ko) * 2022-02-04 2023-04-19 가톨릭대학교 산학협력단 상동 재조합 결핍증 예측 모델의 모델링 방법
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WO2025173014A1 (en) 2024-02-16 2025-08-21 Onecell Diagnostics India Private Limited A method for selecting ovarian cancer patients for parp inhibitor treatment

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Cited By (4)

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Publication number Priority date Publication date Assignee Title
EP3452939A1 (en) * 2016-05-01 2019-03-13 Genome Research Limited Method of characterising a dna sample
EP3452939B1 (en) * 2016-05-01 2025-08-20 Genome Research Limited Method of characterising a dna sample
US12537074B2 (en) 2016-05-01 2026-01-27 Genome Research Limited Method of characterising a DNA sample
CN113462784A (zh) * 2021-08-31 2021-10-01 迈杰转化医学研究(苏州)有限公司 一种构建用于同源重组修复缺陷检测的靶标集合的方法

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AU2021273600A1 (en) 2021-12-16
JP2021112205A (ja) 2021-08-05
US20170283879A1 (en) 2017-10-05
EP4585701A2 (en) 2025-07-16
JP2023015394A (ja) 2023-01-31
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