CA2957258C - Immunological reagents - Google Patents
Immunological reagents Download PDFInfo
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- CA2957258C CA2957258C CA2957258A CA2957258A CA2957258C CA 2957258 C CA2957258 C CA 2957258C CA 2957258 A CA2957258 A CA 2957258A CA 2957258 A CA2957258 A CA 2957258A CA 2957258 C CA2957258 C CA 2957258C
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- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
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| US201462053366P | 2014-09-22 | 2014-09-22 | |
| US62/053,366 | 2014-09-22 | ||
| US201462093368P | 2014-12-17 | 2014-12-17 | |
| US62/093,368 | 2014-12-17 | ||
| PCT/IB2015/055943 WO2016020856A2 (en) | 2014-08-05 | 2015-08-05 | Immunological reagents |
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| TW202442680A (zh) | 2008-12-09 | 2024-11-01 | 美商建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| ES2845609T3 (es) | 2013-05-02 | 2021-07-27 | Anaptysbio Inc | Anticuerpos dirigidos contra muerte programada-1 (PD-1) |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| US9982052B2 (en) * | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| PL3177644T3 (pl) * | 2014-08-05 | 2021-06-14 | MabQuest SA | Immunologiczne reagenty wiążące do PD-1 |
| RS62332B1 (sr) | 2014-11-26 | 2021-10-29 | Xencor Inc | Heterodimerna antitela koja vezuju cd3 i cd20 |
| HRP20201031T1 (hr) | 2015-05-29 | 2020-10-16 | Agenus Inc. | Anti-ctla-4 protutijela i postupci njihove upotrebe |
| TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| WO2017011580A2 (en) | 2015-07-13 | 2017-01-19 | Cytomx Therapeutics, Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
| ES2898958T3 (es) | 2015-07-30 | 2022-03-09 | Macrogenics Inc | Moléculas de unión a PD-1 y LAG-3 y métodos de uso de las mismas |
| CN108289953B (zh) | 2015-09-29 | 2022-03-11 | 细胞基因公司 | Pd-1结合蛋白及其使用方法 |
| MA43186B1 (fr) | 2015-11-03 | 2022-03-31 | Janssen Biotech Inc | Anticorps se liant spécifiquement à pd-1 et leurs utilisations |
| MA44082A (fr) | 2015-12-14 | 2018-10-24 | Macrogenics Inc | Molécules bispécifiques présentant une immunoréactivité par rapport à pd-1 et à ctla-4 et leurs procédés d'utilisation |
| US11214617B2 (en) * | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
| EP3405497A2 (en) | 2016-01-22 | 2018-11-28 | Mabquest SA | Immunological reagents |
| CN106008714B (zh) * | 2016-05-24 | 2019-03-15 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-1人源化单克隆抗体及其应用 |
| CA3024508A1 (en) | 2016-05-27 | 2017-11-30 | Agenus Inc. | Anti-tim-3 antibodies and methods of use thereof |
| IL263542B2 (en) * | 2016-06-14 | 2024-10-01 | Xencor Inc | Bispecific antibodies inhibit immunological checkpoint |
| BR112019004733A2 (pt) | 2016-09-19 | 2019-05-28 | Celgene Corp | métodos de tratamento de distúrbios imunes usando proteínas de ligação a pd-1 |
| US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
| WO2018071500A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
| EP3534950A4 (en) | 2016-11-01 | 2020-05-06 | AnaptysBio, Inc. | Antibodies directed against programmed death- 1 (pd-1) |
| SI3535298T1 (sl) * | 2016-11-02 | 2022-01-31 | Jounce Therapeutics, Inc. | Protitelesa proti pd-1 in njihove uporabe |
| US11013802B2 (en) | 2016-12-07 | 2021-05-25 | Agenus Inc. | Anti-CTLA-4 antibodies and methods of use thereof |
| AU2017373945B2 (en) | 2016-12-07 | 2025-01-23 | Agenus Inc. | Antibodies and methods of use thereof |
| US11591398B2 (en) | 2017-01-06 | 2023-02-28 | Crescendo Biologics Limited | Single domain antibodies to programmed cell death protein 1 (PD-1) |
| MX2019008207A (es) | 2017-01-09 | 2019-12-11 | Tesaro Inc | Métodos para tratar el cáncer con anticuerpos anti-pd-1. |
| KR20190103226A (ko) | 2017-01-13 | 2019-09-04 | 아게누스 인코포레이티드 | Ny-eso-1에 결합하는 t 세포 수용체 및 이의 사용 방법 |
| CN107474135B (zh) * | 2017-02-17 | 2020-08-18 | 广西医科大学 | 抗PD-1的纳米抗体PD-1/Nb20及其制备方法与应用 |
| CN110637031B (zh) | 2017-03-04 | 2024-04-16 | 湘潭腾华生物科技有限公司 | 程序性死亡蛋白1(pd-1)的重组抗体及其用途 |
| AU2018234810B2 (en) | 2017-03-15 | 2023-05-11 | Pandion Operations, Inc. | Targeted immunotolerance |
| JP7297672B2 (ja) | 2017-04-13 | 2023-06-26 | アジェナス インコーポレイテッド | 抗ｃｄ１３７抗体およびその使用方法 |
| CN106939049B (zh) * | 2017-04-20 | 2019-10-01 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制人pd-1抗原与其配体结合的单克隆抗体及其制备方法与应用 |
| US11021537B2 (en) | 2017-05-01 | 2021-06-01 | Agenus Inc. | Anti-TIGIT antibodies and methods of use thereof |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| MX2019014577A (es) | 2017-06-05 | 2020-07-29 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a pd-1 y metodos de uso. |
| MA50084A (fr) | 2017-09-04 | 2020-07-15 | Agenus Inc | Récepteurs de lymphocytes t qui se lient à des phosphopeptides spécifiques de la leucémie de lignée mixte (mll) et méthodes d'utilisation de ces derniers |
| US11021540B2 (en) * | 2017-09-07 | 2021-06-01 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
| CN112272563A (zh) | 2017-11-08 | 2021-01-26 | Xencor股份有限公司 | 使用新颖抗pd-1序列的双特异性和单特异性抗体 |
| KR20200083574A (ko) | 2017-11-13 | 2020-07-08 | 크레센도 바이오로직스 리미티드 | Cd137 및 psma에 결합하는 분자 |
| CN108218988B (zh) * | 2017-11-29 | 2019-10-11 | 广西医科大学 | 抗PD-1的纳米抗体PD-1/Nb52及其制备方法与应用 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| AR114127A1 (es) * | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
| JP7430924B2 (ja) * | 2018-03-22 | 2024-02-14 | ケイレス アーゲー | 拮抗的抗原結合タンパク質 |
| CA3096909A1 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
| CN108840932B (zh) * | 2018-04-28 | 2022-03-29 | 中国科学院微生物研究所 | 一种pd-1特异性抗体及其抗肿瘤应用 |
| CN110404066B (zh) * | 2018-04-28 | 2022-06-17 | 齐鲁制药有限公司 | 一种抗人pd-1的单克隆抗体制剂、联合用药物及其用途 |
| IL279455B1 (en) | 2018-06-20 | 2025-09-01 | Incyte Corp | ANTI-PD-1 ANTIBODIES AND THEIR USES |
| BR112021013157A8 (pt) | 2019-01-03 | 2022-12-06 | Inst Nat Sante Rech Med | Usos de um inibidor de nrp-1, uso de uma combinação, uso de um anticorpo multiespecífico, método ex vivo para predizer, uso de um inibidor, anticorpo multiespecífico, população de células modificadas, método ex vivo de produção e uso de uma população de células t |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| AU2020322021A1 (en) | 2019-07-30 | 2022-02-10 | Pairwise Plants Services, Inc. | Morphogenic regulators and methods of using the same |
| US11629190B2 (en) | 2019-08-15 | 2023-04-18 | Oregon State University | Canine antibody therapeutic for treating cancer |
| KR102231974B1 (ko) * | 2019-08-23 | 2021-03-25 | 한국과학기술원 | 사람의 프로그램된 세포사멸 단백질(pd-1)에 선택적으로 결합하는 신규한 폴리펩티드 및 이의 용도 |
| CR20220076A (es) | 2019-08-30 | 2022-06-24 | Agenus Inc | Anticuerpos anti-cd96 y sus métodos de uso |
| EP4048063A4 (en) | 2019-10-23 | 2023-12-06 | Pairwise Plants Services, Inc. | Compositions and methods for rna-templated editing in plants |
| AU2020372931A1 (en) | 2019-10-30 | 2022-05-12 | Pairwise Plants Services, Inc. | Type V CRISPR-Cas base editors and methods of use thereof |
| JP7785002B2 (ja) | 2019-11-05 | 2025-12-12 | ペアーワイズ プランツ サービシズ， インコーポレイテッド | 対立遺伝子のｒｎａにコードされたｄｎａの置換のための組成物および方法 |
| US20230034677A1 (en) | 2019-11-21 | 2023-02-02 | INSERM (Institut National de la Santé et la Recherche (Médicale) | Novel immunotherapies targeting pd-1 with anti-pd-1/il-15 immunocytokines |
| WO2021113788A1 (en) | 2019-12-06 | 2021-06-10 | Pairwise Plants Services, Inc. | Recruitment methods and compounds, compositions and systems for recruitment |
| CA3169462A1 (en) | 2020-01-30 | 2021-08-05 | Pairwise Plants Services, Inc. | Compositions, systems, and methods for base diversification |
| WO2021155084A1 (en) | 2020-01-31 | 2021-08-05 | Pairwise Plants Services, Inc. | Suppression of shade avoidance response in plants |
| US20230063560A1 (en) | 2020-02-04 | 2023-03-02 | Pairwise Plans Services, Inc. | Thornless and/or prickleless rubus plants |
| CA3172333A1 (en) | 2020-02-21 | 2021-08-26 | Pairwise Plants Services, Inc. | Improved resistance to soybean cyst nematode through gene editing |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| US11999946B2 (en) | 2020-03-26 | 2024-06-04 | Pairwise Plants Services, Inc. | Methods for controlling meristem size for crop improvement |
| US11882808B2 (en) | 2020-03-27 | 2024-01-30 | Pairwise Plants Services, Inc. | Methods for improving resistance to soybean rust |
| US20230175006A1 (en) | 2020-04-06 | 2023-06-08 | Pairwise Plants Services, Inc. | Methods and compositions for increasing resistance to ear rot and stem rot disease in maize |
| CN119431532A (zh) | 2020-04-16 | 2025-02-14 | 成对植物服务股份有限公司 | 控制分生组织大小以改良作物的方法 |
| BR112022022352A2 (pt) * | 2020-05-04 | 2023-01-10 | Inhibrx Inc | Polipeptídeos que se ligam à pd-1 canina e usos dos mesmos |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| MX2022014974A (es) | 2020-05-26 | 2023-01-11 | Boehringer Ingelheim Int | Anticuerpos anti-pd-1. |
| MX2022015107A (es) | 2020-06-02 | 2023-03-01 | Pairwise Plants Services Inc | Metodos para controlar el tama?o del meristema para mejorar los cultivos. |
| AR122661A1 (es) | 2020-06-17 | 2022-09-28 | Pairwise Plants Services Inc | Métodos para el control del tamaño del meristemo para la mejora de cultivos |
| CA3187135A1 (en) | 2020-06-30 | 2022-01-06 | Pairwise Plants Services, Inc. | Compositions, systems, and methods for base diversification |
| EP4204436A1 (en) | 2020-08-28 | 2023-07-05 | Pairwise Plants Services, Inc. | Engineered crispr-cas proteins and methods of use thereof |
| MX2023005150A (es) | 2020-11-06 | 2023-05-26 | Pairwise Plants Services Inc | Composiciones y metodos para el reemplazo de alelos con adn codificado por arn. |
| BR112023015909A2 (pt) | 2021-02-11 | 2023-11-21 | Monsanto Technology Llc | Métodos e composições para modificar níveis de citocinina oxidase em plantas |
| CN117203227A (zh) | 2021-02-25 | 2023-12-08 | 成对植物服务股份有限公司 | 用于修饰植物中根结构的方法和组合物 |
| CN113189078B (zh) * | 2021-03-04 | 2024-04-16 | 吉林大学 | 一种靶向药物的高通量筛选方法 |
| KR20230156079A (ko) | 2021-03-09 | 2023-11-13 | 젠코어 인코포레이티드 | Cd3과 cldn6에 결합하는 이종이량체 항체 |
| WO2022265905A2 (en) | 2021-06-14 | 2022-12-22 | Pairwise Plants Services, Inc. | Reporter constructs, compositions comprising the same, and methods of use thereof |
| EP4355083A1 (en) | 2021-06-17 | 2024-04-24 | Pairwise Plants Services, Inc. | Modification of growth regulating factor family transcription factors in soybean |
| UY39827A (es) | 2021-06-24 | 2023-01-31 | Pairwise Plants Services Inc | Modificación de genes de ubiquitina ligasa e3 hect para mejorar los rasgos de rendimiento |
| CA3224982A1 (en) | 2021-07-01 | 2023-01-05 | Pairwise Plants Services, Inc. | Methods and compositions for enhancing root system development |
| CN113702351B (zh) * | 2021-07-14 | 2024-08-20 | 吉林大学 | 一种对天然药物产物进行筛选和垂钓的方法 |
| WO2023019188A1 (en) | 2021-08-12 | 2023-02-16 | Pairwise Plants Services, Inc. | Modification of brassinosteroid receptor genes to improve yield traits |
| UY39902A (es) | 2021-08-17 | 2023-03-31 | Pairwise Plants Services Inc | Métodos y composiciones para modificar genes de histidina quinasa receptores de citoquinina en plant |
| MX2024002276A (es) | 2021-08-30 | 2024-03-07 | Pairwise Plants Services Inc | Modificacion de genes de peptidasa de union a ubiquitinaen plantas para mejorar rasgos de rendimiento. |
| AR126938A1 (es) | 2021-09-02 | 2023-11-29 | Pairwise Plants Services Inc | Métodos y composiciones para mejorar la arquitectura de las plantas y los rasgos de rendimiento |
| US20230266293A1 (en) | 2021-09-21 | 2023-08-24 | Pairwise Plants Services, Inc. | Color-based and/or visual methods for identifying the presence of a transgene and compositions and constructs relating to the same |
| CN118382634A (zh) | 2021-09-21 | 2024-07-23 | 成对植物服务股份有限公司 | 用于减少油菜荚果开裂的方法和组合物 |
| AR127236A1 (es) | 2021-10-04 | 2024-01-03 | Pairwise Plants Services Inc | Métodos para mejorar la fertilidad de la flor y el rendimiento de semillas |
| US20230116819A1 (en) | 2021-10-07 | 2023-04-13 | Pairwise Plants Services, Inc. | Methods for improving floret fertility and seed yield |
| AR127904A1 (es) | 2021-12-09 | 2024-03-06 | Pairwise Plants Services Inc | Métodos para mejorar la fertilidad de floretes y el rendimiento de semillas |
| US20230295646A1 (en) | 2021-12-13 | 2023-09-21 | Pairwise Plants Services, Inc. | Model editing systems and methods relating to the same |
| US20250146008A1 (en) | 2022-01-06 | 2025-05-08 | Pairwise Plants Services, Inc. | Methods and compositions for trichome removal |
| IL314524A (en) | 2022-01-28 | 2024-09-01 | Georgiamune Inc | Antibodies to programmed cell death protein 1 that are agonists for PD-1 |
| AR128372A1 (es) | 2022-01-31 | 2024-04-24 | Pairwise Plants Services Inc | Supresión de la respuesta de evitación de la sombra en las plantas |
| US20230383271A1 (en) | 2022-02-28 | 2023-11-30 | Pairwise Plants Services, Inc. | Engineered proteins and methods of use thereof |
| CN119072487A (zh) | 2022-03-02 | 2024-12-03 | 成对植物服务股份有限公司 | 用于改善产量性状的油菜素类固醇受体基因的修饰 |
| CN115015536A (zh) * | 2022-03-30 | 2022-09-06 | 邹灵龙 | 一种即时检测pd-1抗体药浓度的试纸条和试剂盒 |
| EP4499842A1 (en) | 2022-03-31 | 2025-02-05 | Pairwise Plants Services, Inc. | Early flowering rosaceae plants with improved characteristics |
| CA3247405A1 (en) | 2022-04-07 | 2023-10-12 | Pairwise Plants Services, Inc. | METHODS AND COMPOSITIONS FOR IMPROVING RESISTANCE TO FUSARIA BROAD OF THE SPINE |
| EP4511387A1 (en) | 2022-04-21 | 2025-02-26 | Pairwise Plants Services, Inc. | Methods and compositions for improving yield traits |
| EP4519428A1 (en) | 2022-05-02 | 2025-03-12 | Pairwise Plants Services, Inc. | Methods and compositions for enhancing yield and disease resistance |
| WO2023215809A1 (en) | 2022-05-05 | 2023-11-09 | Pairwise Plants Services, Inc. | Methods and compositions for modifying root architecture and/or improving plant yield traits |
| UY40326A (es) | 2022-06-27 | 2023-12-29 | Pairwise Plants Services Inc | Métodos y composiciones para modificar el escape a la sombra en plantas |
| EP4547692A1 (en) | 2022-06-29 | 2025-05-07 | Pairwise Plants Services, Inc. | Methods and compositions for controlling meristem size for crop improvement |
| CA3259679A1 (en) | 2022-06-29 | 2024-01-04 | Pairwise Plants Services, Inc. | METHODS AND COMPOSITIONS FOR REGULATING MERISTEMUM SIZE TO IMPROVE CROP PRODUCTION |
| US20240043857A1 (en) | 2022-08-04 | 2024-02-08 | Pairwise Plants Services, Inc. | Methods and compositions for improving yield traits |
| CA3264244A1 (en) | 2022-08-11 | 2024-02-15 | Pairwise Plants Services, Inc. | METHODS AND COMPOSITIONS FOR REGULATING MERISTEME SIZE FOR CROP IMPROVEMENT |
| US20240090466A1 (en) | 2022-09-08 | 2024-03-21 | Pairwise Plants Services, Inc. | Methods and compositions for improving yield characteristics in plants |
| WO2024130102A2 (en) | 2022-12-16 | 2024-06-20 | Pairwise Plants Services, Inc. | Fusion proteins comprising an intein polypeptide and methods of use thereof |
| CN120359295A (zh) | 2022-12-21 | 2025-07-22 | 成对植物服务股份有限公司 | 工程化蛋白质和其使用方法 |
| WO2024173622A1 (en) | 2023-02-16 | 2024-08-22 | Pairwise Plants Services, Inc. | Methods and compositions for modifying shade avoidance in plants |
| US20240327811A1 (en) | 2023-03-01 | 2024-10-03 | Pairwise Plants Services, Inc. | Engineered proteins and methods of use thereof |
| AR132019A1 (es) | 2023-03-02 | 2025-05-21 | Pairwise Plants Services Inc | Métodos y composiciones para modificar la evitación de la sombra en plantas |
| AR132071A1 (es) | 2023-03-09 | 2025-05-21 | Pairwise Plants Services Inc | Modificación de genes de la vía de señalización de brasinoesteroide para mejorar rasgos de rendimiento en plantas |
| AU2024248777A1 (en) | 2023-03-30 | 2025-10-02 | Pairwise Plants Services, Inc. | Methods and compositions for reducing thorns or prickles in plants |
| WO2024216028A1 (en) | 2023-04-12 | 2024-10-17 | Agenus Inc. | Methods of treating cancer using an anti-ctla4 antibody and an enpp1 inhibitor |
| WO2024233926A1 (en) | 2023-05-10 | 2024-11-14 | Regeneron Pharmaceuticals, Inc. | Cd20-pd1 binding molecules and methods of use thereof |
| UY40746A (es) | 2023-05-18 | 2024-12-13 | Pairwise Plants Services Inc | Métodos y composiciones para mejorar las características de rendimiento de las plantas |
| AR133164A1 (es) | 2023-07-18 | 2025-09-03 | Pairwise Plants Services Inc | Métodos y composiciones para modificar la arquitectura radicular en plantas |
| AR133310A1 (es) | 2023-07-27 | 2025-09-17 | Pairwise Plants Services Inc | Métodos y composiciones para modificar rasgos de rendimiento de las plantas |
| AR133901A1 (es) | 2023-09-21 | 2025-11-12 | Pairwise Plants Services Inc | Plantas de frambuesa negra de floración temprana con características mejoradas |
| WO2025072430A1 (en) | 2023-09-26 | 2025-04-03 | Pairwise Plants Services, Inc. | Crispr-cas fusion proteins with adenine base editor functionality, compositions comprising the same, and methods of use thereof |
| US20250129348A1 (en) | 2023-10-09 | 2025-04-24 | Pairwise Plants Services, Inc. | Circular permutants, compositions comprising the same, and methods of use thereof |
| WO2025080600A1 (en) | 2023-10-11 | 2025-04-17 | Pairwise Plants Services, Inc. | Methods and compositions for improving crop yield traits |
| US20250207154A1 (en) | 2023-12-21 | 2025-06-26 | Pairwise Plants Services, Inc. | Compositions and methods for rna-encoded dna-replacement of alleles |
| WO2025178902A1 (en) | 2024-02-22 | 2025-08-28 | Pairwise Plants Services, Inc. | Methods and compositions for improving yield characteristics in plants |
| WO2025252857A1 (en) | 2024-06-05 | 2025-12-11 | Institut National de la Santé et de la Recherche Médicale | Il-15 muteins with ph-dependent binding for il-15ralpha |
| WO2025252855A1 (en) | 2024-06-05 | 2025-12-11 | Institut National de la Santé et de la Recherche Médicale | IL-15 MUTEINS WITH PH-DEPENDENT BINDING FOR IL-15Rbeta |
| US12428636B1 (en) | 2024-07-08 | 2025-09-30 | Pairwise Plants Services, Inc. | Methods and compositions for modification of protospacer adjacent motif specificity of CAS12A |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| WO1988006626A1 (en) | 1987-03-02 | 1988-09-07 | Whitehead Institute For Biomedical Research | Recombinant mycobacterial vaccine |
| US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP2877509B2 (ja) | 1989-05-19 | 1999-03-31 | アムジエン・インコーポレーテツド | メタロプロテイナーゼ阻害剤 |
| WO1991013157A1 (en) | 1990-02-26 | 1991-09-05 | Commonwealth Scientific And Industrial Research Organisation | Shuttle plasmid for escherichia coli and mycobacteria |
| GB9015888D0 (en) | 1990-07-19 | 1990-09-05 | Smithkline Biolog | Vectors |
| WO1992003918A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| CA2110682A1 (en) | 1991-06-06 | 1992-12-10 | Charles K. Stover | Induction of ctl responses to foreign antigens expressed in mycobacteria |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| JP3454275B2 (ja) | 1992-06-05 | 2003-10-06 | 佑 本庶 | プログラムされた細胞死に関連した新規なポリペプチドおよびそれをコードするｄｎａ |
| AU7203194A (en) | 1993-06-04 | 1995-01-03 | New York University | Bispecific human monoclonal antibodies specific for human immunodeficiency virus |
| CA2143491C (en) | 1994-03-01 | 2011-02-22 | Yasumasa Ishida | A novel peptide related to human programmed cell death and dna encoding it |
| EP1210428B1 (en) | 1999-08-23 | 2015-03-18 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
| EP1445264B1 (en) | 2001-07-31 | 2011-09-14 | Ono Pharmaceutical Co., Ltd. | Substance specific to pd-1 |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| ES2367430T3 (es) * | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| PT1587907E (pt) | 2003-01-07 | 2011-04-08 | Dyax Corp | Biblioteca de domínios de kunitz |
| KR20050107399A (ko) | 2003-01-23 | 2005-11-11 | 오노 야꾸힝 고교 가부시키가이샤 | 인간 ｐｄ-1에 대하여 특이성을 갖는 물질 |
| EP1896582A4 (en) * | 2005-05-09 | 2009-04-08 | Ono Pharmaceutical Co | HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS |
| MX349137B (es) | 2005-06-08 | 2017-07-13 | Dana-Farber Cancer Inst | Metodos y composiciones para el tratamiento de infecciones persistentes y cancer por inhibicion de la ruta de muerte celular programada (pd-1). |
| EP2133365B1 (en) | 2006-12-27 | 2017-05-17 | Emory University | Compositions and methods for the treatment of infections and tumors |
| WO2008156712A1 (en) | 2007-06-18 | 2008-12-24 | N. V. Organon | Antibodies to human programmed death receptor pd-1 |
| US20090028857A1 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| WO2009114335A2 (en) * | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| TW201007669A (en) | 2008-08-01 | 2010-02-16 | Integrated Solutions Technology Inc | A display driving device and the driving method thereof |
| EP2342228B1 (en) * | 2008-09-12 | 2017-09-06 | Oxford University Innovation Limited | Pd-1 specific antibodies and uses thereof |
| WO2010029435A1 (en) * | 2008-09-12 | 2010-03-18 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
| US8552154B2 (en) | 2008-09-26 | 2013-10-08 | Emory University | Anti-PD-L1 antibodies and uses therefor |
| WO2010089411A2 (en) | 2009-02-09 | 2010-08-12 | Universite De La Mediterranee | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| WO2011100841A1 (en) | 2010-02-16 | 2011-08-25 | Valorisation-Recherche, Limited Partnership | Pd-1 modulation and uses thereof for modulating hiv replication |
| WO2011110604A1 (en) * | 2010-03-11 | 2011-09-15 | Ucb Pharma, S.A. | Pd-1 antibody |
| TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| CA2802344C (en) | 2010-06-18 | 2023-06-13 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| WO2012062218A1 (en) | 2010-11-11 | 2012-05-18 | The University Of Hong Kong | Soluble pd-1 variants, fusion constructs, and uses thereof |
| DK2691112T3 (en) | 2011-03-31 | 2018-07-30 | Merck Sharp & Dohme | STABLE FORMULATIONS OF ANTIBODIES AGAINST HUMAN PD (PROGRAMMED DEATH) 1- RECEPTOR AND RELATED TREATMENTS |
| PT2699264T (pt) | 2011-04-20 | 2018-05-23 | Medimmune Llc | Anticorpos e outras moléculas que ligam b7-h1 e pd-1 |
| US9090994B2 (en) | 2011-06-08 | 2015-07-28 | Nanjingjinsirui Science & Technology Biology Corp. | Antibody humanization by framework assembly |
| TWI835048B (zh) * | 2011-08-01 | 2024-03-11 | 美商建南德克公司 | 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法 |
| WO2013043569A1 (en) | 2011-09-20 | 2013-03-28 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
| EP2817619B1 (en) * | 2012-02-23 | 2018-07-25 | Sloan Kettering Institute For Cancer Research | Prediction of responsiveness to treatment with immunomodulatory therapeutics and method of monitoring abscopal effects during such treatment |
| WO2013169693A1 (en) | 2012-05-09 | 2013-11-14 | Bristol-Myers Squibb Company | Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody |
| EP2904011B1 (en) * | 2012-10-02 | 2017-08-23 | Bristol-Myers Squibb Company | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
| ES2845609T3 (es) | 2013-05-02 | 2021-07-27 | Anaptysbio Inc | Anticuerpos dirigidos contra muerte programada-1 (PD-1) |
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| EA034666B1 (ru) * | 2013-09-13 | 2020-03-04 | Бейджин Свитзерланд Гмбх | Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| PL3177644T3 (pl) * | 2014-08-05 | 2021-06-14 | MabQuest SA | Immunologiczne reagenty wiążące do PD-1 |
| US9982052B2 (en) * | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| US10239942B2 (en) | 2014-12-22 | 2019-03-26 | Pd-1 Acquisition Group, Llc | Anti-PD-1 antibodies |
| US11214617B2 (en) * | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
| EP3405497A2 (en) * | 2016-01-22 | 2018-11-28 | Mabquest SA | Immunological reagents |
-
2015
- 2015-08-05 PL PL15750136T patent/PL3177644T3/pl unknown
- 2015-08-05 WO PCT/IB2015/055943 patent/WO2016020856A2/en not_active Ceased
- 2015-08-05 ES ES15750136T patent/ES2847311T3/es active Active
- 2015-08-05 EP EP15750136.2A patent/EP3177644B1/en active Active
- 2015-08-05 PT PT157501362T patent/PT3177644T/pt unknown
- 2015-08-05 AU AU2015298356A patent/AU2015298356B2/en active Active
- 2015-08-05 KR KR1020177004575A patent/KR102357893B1/ko active Active
- 2015-08-05 JP JP2017526774A patent/JP6629321B2/ja active Active
- 2015-08-05 US US15/329,760 patent/US9982053B2/en active Active
- 2015-08-05 CA CA2957258A patent/CA2957258C/en active Active
- 2015-08-05 SG SG11201700672YA patent/SG11201700672YA/en unknown
- 2015-08-05 CN CN201580042199.7A patent/CN107074947B/zh active Active
- 2015-08-05 DK DK15750136.2T patent/DK3177644T3/da active
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2018
- 2018-05-17 US US15/981,977 patent/US11130807B2/en active Active
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2021
- 2021-09-27 US US17/485,752 patent/US20220169733A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016020856A2 (en) | 2016-02-11 |
| US20220169733A1 (en) | 2022-06-02 |
| JP6629321B2 (ja) | 2020-01-15 |
| US20190106493A1 (en) | 2019-04-11 |
| DK3177644T3 (da) | 2021-01-11 |
| WO2016020856A3 (en) | 2016-03-31 |
| US20170226210A1 (en) | 2017-08-10 |
| CN107074947A (zh) | 2017-08-18 |
| EP3177644B1 (en) | 2020-10-07 |
| AU2015298356B2 (en) | 2020-11-19 |
| US11130807B2 (en) | 2021-09-28 |
| CA2957258A1 (en) | 2016-02-11 |
| PL3177644T3 (pl) | 2021-06-14 |
| EP3177644A2 (en) | 2017-06-14 |
| JP2017531028A (ja) | 2017-10-19 |
| AU2015298356A1 (en) | 2017-02-16 |
| CN107074947B (zh) | 2021-04-09 |
| US9982053B2 (en) | 2018-05-29 |
| PT3177644T (pt) | 2021-01-13 |
| KR102357893B1 (ko) | 2022-02-04 |
| ES2847311T3 (es) | 2021-08-02 |
| KR20170069996A (ko) | 2017-06-21 |
| SG11201700672YA (en) | 2017-02-27 |
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