CA2957118A1 - Carrier molecule for antigens - Google Patents
Carrier molecule for antigens Download PDFInfo
- Publication number
- CA2957118A1 CA2957118A1 CA2957118A CA2957118A CA2957118A1 CA 2957118 A1 CA2957118 A1 CA 2957118A1 CA 2957118 A CA2957118 A CA 2957118A CA 2957118 A CA2957118 A CA 2957118A CA 2957118 A1 CA2957118 A1 CA 2957118A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- amino acid
- polypeptide
- acid sequence
- saccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091007433 antigens Proteins 0.000 title claims abstract description 149
- 102000036639 antigens Human genes 0.000 title claims abstract description 149
- 239000000427 antigen Substances 0.000 title claims abstract description 142
- 238000000034 method Methods 0.000 claims abstract description 83
- 241000193985 Streptococcus agalactiae Species 0.000 claims abstract description 45
- 230000028993 immune response Effects 0.000 claims abstract description 27
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 21
- 101150078778 SPB1 gene Proteins 0.000 claims abstract description 18
- 241000124008 Mammalia Species 0.000 claims abstract description 11
- 150000001720 carbohydrates Chemical class 0.000 claims description 241
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 197
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 189
- 229920001184 polypeptide Polymers 0.000 claims description 186
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 70
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- 239000003814 drug Substances 0.000 claims description 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 13
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 5
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 5
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- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 10
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A—HUMAN NECESSITIES
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- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
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- Chemical & Material Sciences (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP14179945 | 2014-08-05 | ||
| EP14179945.2 | 2014-08-05 | ||
| PCT/EP2015/068012 WO2016020413A1 (en) | 2014-08-05 | 2015-08-05 | Carrier molecule for antigens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2957118A1 true CA2957118A1 (en) | 2016-02-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2957118A Abandoned CA2957118A1 (en) | 2014-08-05 | 2015-08-05 | Carrier molecule for antigens |
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|---|---|
| US (1) | US10245310B2 (enExample) |
| EP (1) | EP3177324A1 (enExample) |
| JP (1) | JP2017523985A (enExample) |
| KR (1) | KR20170039709A (enExample) |
| CN (1) | CN108064174A (enExample) |
| AR (1) | AR101455A1 (enExample) |
| AU (1) | AU2015299008B2 (enExample) |
| BE (1) | BE1022792B1 (enExample) |
| BR (1) | BR112017002183A2 (enExample) |
| CA (1) | CA2957118A1 (enExample) |
| EA (1) | EA201790239A1 (enExample) |
| IL (1) | IL250238A0 (enExample) |
| MX (1) | MX2017001638A (enExample) |
| SG (1) | SG11201700673RA (enExample) |
| WO (1) | WO2016020413A1 (enExample) |
| ZA (1) | ZA201700824B (enExample) |
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| PL2878307T3 (pl) * | 2005-06-27 | 2020-01-31 | Glaxosmithkline Biologicals S.A. | Kompozycja immunogenna |
| WO2018104889A1 (en) | 2016-12-06 | 2018-06-14 | Glaxosmithkline Biologicals Sa | Purification process for capsular polysaccharide |
| KR20190103256A (ko) | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| BR112019020853A2 (pt) * | 2017-04-04 | 2020-05-12 | Avidea Technologies, Inc. | Vacinas à base de peptídeo, métodos de fabricação e usos das mesmas para induzir uma resposta imune |
| EP3638301A1 (en) | 2017-06-16 | 2020-04-22 | GlaxoSmithKline Biologicals S.A. | Method of treatment |
| WO2019217665A1 (en) * | 2018-05-09 | 2019-11-14 | West Virginia University | Iron-acquisition receptor peptide administration for vaccination against pseudomonas aeruginosa |
| EP3574915A1 (en) * | 2018-05-29 | 2019-12-04 | Neovacs | Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity |
| WO2020010000A1 (en) * | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Improved methods for the preparation of immunogenic conjugates |
| AU2019299836B2 (en) * | 2018-07-04 | 2025-08-21 | Vaxcyte, Inc. | Improvements in immunogenic conjugates |
| CN108840914B (zh) * | 2018-08-13 | 2022-07-01 | 内蒙古民族大学 | 一种具有免疫原性的多肽、其抗体的制备方法以及用途 |
| MX2021012120A (es) * | 2019-04-02 | 2021-11-03 | Vaxcyte Inc | Sintesis optimizada libre de celulas del antigeno b del plasmido de invasion y composiciones y metodos de uso relacionados. |
| JP2023503086A (ja) | 2019-11-22 | 2023-01-26 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 細菌サッカリド複合糖質ワクチンの用法及び用量 |
| WO2021250626A2 (en) * | 2020-06-12 | 2021-12-16 | Glaxosmithkline Biologicals Sa | Dock tag system |
| US20230303637A1 (en) | 2020-06-12 | 2023-09-28 | Glaxosmithkline Biologicals Sa | Gbs ferritin nanoparticles |
| CN112979797B (zh) * | 2021-04-28 | 2022-04-01 | 中国检验检疫科学研究院 | 一种抗赤羽病病毒单克隆抗体及其制备方法与应用 |
| GB202215634D0 (en) * | 2022-10-21 | 2022-12-07 | Glaxosmithkline Biologicals Sa | Polypeptide scaffold |
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| US20090104218A1 (en) * | 2004-12-22 | 2009-04-23 | J. Craig Venter Institute | Group B Streptococcus |
| GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| EP2063911A2 (en) | 2006-07-26 | 2009-06-03 | Novartis Ag | Immunogenic compositions for gram positive bacteria |
| GB0802503D0 (en) * | 2008-02-11 | 2008-03-19 | Novartis Ag | Hybrid polypeptide |
| US8465751B2 (en) * | 2009-01-12 | 2013-06-18 | Novartis Ag | Cna—B domain antigens in vaccines against gram positive bacteria |
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| GB201114923D0 (en) * | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
| US20150273042A1 (en) * | 2012-02-24 | 2015-10-01 | Novartis Ag | Pilus proteins and compositions |
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- 2015-08-05 WO PCT/EP2015/068012 patent/WO2016020413A1/en not_active Ceased
- 2015-08-05 EA EA201790239A patent/EA201790239A1/ru unknown
- 2015-08-05 CA CA2957118A patent/CA2957118A1/en not_active Abandoned
- 2015-08-05 US US15/501,474 patent/US10245310B2/en active Active
-
2017
- 2017-01-23 IL IL250238A patent/IL250238A0/en unknown
- 2017-02-02 ZA ZA2017/00824A patent/ZA201700824B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10245310B2 (en) | 2019-04-02 |
| BR112017002183A2 (pt) | 2018-01-16 |
| JP2017523985A (ja) | 2017-08-24 |
| WO2016020413A1 (en) | 2016-02-11 |
| EP3177324A1 (en) | 2017-06-14 |
| US20170224803A1 (en) | 2017-08-10 |
| AU2015299008A1 (en) | 2017-02-23 |
| EA201790239A1 (ru) | 2017-07-31 |
| BE1022792B1 (fr) | 2016-09-06 |
| AU2015299008B2 (en) | 2018-08-02 |
| IL250238A0 (en) | 2017-03-30 |
| CN108064174A (zh) | 2018-05-22 |
| MX2017001638A (es) | 2017-04-27 |
| SG11201700673RA (en) | 2017-02-27 |
| BE1022792A1 (fr) | 2016-09-06 |
| KR20170039709A (ko) | 2017-04-11 |
| AR101455A1 (es) | 2016-12-21 |
| ZA201700824B (en) | 2019-07-31 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20200831 |