CA2957118A1 - Carrier molecule for antigens - Google Patents
Carrier molecule for antigens Download PDFInfo
- Publication number
- CA2957118A1 CA2957118A1 CA2957118A CA2957118A CA2957118A1 CA 2957118 A1 CA2957118 A1 CA 2957118A1 CA 2957118 A CA2957118 A CA 2957118A CA 2957118 A CA2957118 A CA 2957118A CA 2957118 A1 CA2957118 A1 CA 2957118A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- amino acid
- polypeptide
- acid sequence
- saccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091007433 antigens Proteins 0.000 title claims abstract description 149
- 102000036639 antigens Human genes 0.000 title claims abstract description 149
- 239000000427 antigen Substances 0.000 title claims abstract description 142
- 238000000034 method Methods 0.000 claims abstract description 83
- 241000193985 Streptococcus agalactiae Species 0.000 claims abstract description 45
- 230000028993 immune response Effects 0.000 claims abstract description 27
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 21
- 101150078778 SPB1 gene Proteins 0.000 claims abstract description 18
- 241000124008 Mammalia Species 0.000 claims abstract description 11
- 150000001720 carbohydrates Chemical class 0.000 claims description 241
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 197
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 189
- 229920001184 polypeptide Polymers 0.000 claims description 186
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 70
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- 239000003814 drug Substances 0.000 claims description 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 13
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 5
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 5
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- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 10
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A—HUMAN NECESSITIES
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- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Microbiology (AREA)
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- Virology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179945 | 2014-08-05 | ||
| EP14179945.2 | 2014-08-05 | ||
| PCT/EP2015/068012 WO2016020413A1 (en) | 2014-08-05 | 2015-08-05 | Carrier molecule for antigens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2957118A1 true CA2957118A1 (en) | 2016-02-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2957118A Abandoned CA2957118A1 (en) | 2014-08-05 | 2015-08-05 | Carrier molecule for antigens |
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| Country | Link |
|---|---|
| US (1) | US10245310B2 (enExample) |
| EP (1) | EP3177324A1 (enExample) |
| JP (1) | JP2017523985A (enExample) |
| KR (1) | KR20170039709A (enExample) |
| CN (1) | CN108064174A (enExample) |
| AR (1) | AR101455A1 (enExample) |
| AU (1) | AU2015299008B2 (enExample) |
| BE (1) | BE1022792B1 (enExample) |
| BR (1) | BR112017002183A2 (enExample) |
| CA (1) | CA2957118A1 (enExample) |
| EA (1) | EA201790239A1 (enExample) |
| IL (1) | IL250238A0 (enExample) |
| MX (1) | MX2017001638A (enExample) |
| SG (1) | SG11201700673RA (enExample) |
| WO (1) | WO2016020413A1 (enExample) |
| ZA (1) | ZA201700824B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2008543907A (ja) * | 2005-06-27 | 2008-12-04 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
| EP3551668A1 (en) | 2016-12-06 | 2019-10-16 | GlaxoSmithKline Biologicals S.A. | Purification process for capsular polysaccharide |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| WO2018126229A2 (en) | 2016-12-30 | 2018-07-05 | Sutrovax, Inc. | Polypeptide-antigen conjugates with non-natural amino acids |
| CA3057715A1 (en) * | 2017-04-04 | 2018-10-11 | Avidea Technologies, Inc. | Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response |
| CA3066020A1 (en) | 2017-06-16 | 2018-12-20 | Glaxosmithkline Biologicals Sa | Method of treatment |
| WO2019217665A1 (en) * | 2018-05-09 | 2019-11-14 | West Virginia University | Iron-acquisition receptor peptide administration for vaccination against pseudomonas aeruginosa |
| EP3574915A1 (en) * | 2018-05-29 | 2019-12-04 | Neovacs | Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity |
| ES2989087T3 (es) * | 2018-07-04 | 2024-11-25 | Vaxcyte Inc | Mejoras en conjugados inmunogénicos |
| WO2020010000A1 (en) * | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Improved methods for the preparation of immunogenic conjugates |
| CN108840914B (zh) * | 2018-08-13 | 2022-07-01 | 内蒙古民族大学 | 一种具有免疫原性的多肽、其抗体的制备方法以及用途 |
| AU2020253332A1 (en) * | 2019-04-02 | 2021-11-25 | Vaxcyte, Inc. | Optimized cell-free synthesis of Invasion Plasmid Antigen B and related compositions and methods of use |
| US20220387614A1 (en) | 2019-11-22 | 2022-12-08 | Glaxosmithkline Biologicals Sa | Dosage and administration of a bacterial saccharide glycoconjugate vaccine |
| EP4165064A2 (en) * | 2020-06-12 | 2023-04-19 | GlaxoSmithKline Biologicals S.A. | Dock tag system |
| WO2021250625A2 (en) | 2020-06-12 | 2021-12-16 | Glaxosmithkline Biologicals Sa | Gbs ferritin nanoparticles |
| CN112979797B (zh) * | 2021-04-28 | 2022-04-01 | 中国检验检疫科学研究院 | 一种抗赤羽病病毒单克隆抗体及其制备方法与应用 |
| GB202215634D0 (en) * | 2022-10-21 | 2022-12-07 | Glaxosmithkline Biologicals Sa | Polypeptide scaffold |
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| WO2006078318A2 (en) * | 2004-07-29 | 2006-07-27 | Novartis Vaccines And Diagnostics Inc. | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
| JP2008525033A (ja) | 2004-12-22 | 2008-07-17 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド | Ｂ群連鎖球菌 |
| GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| EP2063911A2 (en) * | 2006-07-26 | 2009-06-03 | Novartis Ag | Immunogenic compositions for gram positive bacteria |
| GB0802503D0 (en) * | 2008-02-11 | 2008-03-19 | Novartis Ag | Hybrid polypeptide |
| WO2010079464A1 (en) | 2009-01-12 | 2010-07-15 | Novartis Ag | Cna_b domain antigens in vaccines against gram positive bacteria |
| GB201003333D0 (en) | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
| GB201005625D0 (en) * | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
| GB201114923D0 (en) | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
| AU2013224026A1 (en) | 2012-02-24 | 2014-08-21 | Novartis Ag | Pilus proteins and compositions |
-
2015
- 2015-08-05 SG SG11201700673RA patent/SG11201700673RA/en unknown
- 2015-08-05 US US15/501,474 patent/US10245310B2/en active Active
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- 2015-08-05 MX MX2017001638A patent/MX2017001638A/es unknown
- 2015-08-05 CA CA2957118A patent/CA2957118A1/en not_active Abandoned
- 2015-08-05 WO PCT/EP2015/068012 patent/WO2016020413A1/en not_active Ceased
- 2015-08-05 JP JP2017506294A patent/JP2017523985A/ja active Pending
- 2015-08-05 AR ARP150102512A patent/AR101455A1/es unknown
- 2015-08-05 BE BE2015/5496A patent/BE1022792B1/fr not_active IP Right Cessation
- 2015-08-05 EP EP15744610.5A patent/EP3177324A1/en not_active Withdrawn
- 2015-08-05 CN CN201580053997.XA patent/CN108064174A/zh active Pending
- 2015-08-05 EA EA201790239A patent/EA201790239A1/ru unknown
- 2015-08-05 KR KR1020177005840A patent/KR20170039709A/ko not_active Withdrawn
-
2017
- 2017-01-23 IL IL250238A patent/IL250238A0/en unknown
- 2017-02-02 ZA ZA2017/00824A patent/ZA201700824B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10245310B2 (en) | 2019-04-02 |
| WO2016020413A1 (en) | 2016-02-11 |
| CN108064174A (zh) | 2018-05-22 |
| US20170224803A1 (en) | 2017-08-10 |
| MX2017001638A (es) | 2017-04-27 |
| AU2015299008A1 (en) | 2017-02-23 |
| JP2017523985A (ja) | 2017-08-24 |
| IL250238A0 (en) | 2017-03-30 |
| SG11201700673RA (en) | 2017-02-27 |
| AR101455A1 (es) | 2016-12-21 |
| KR20170039709A (ko) | 2017-04-11 |
| AU2015299008B2 (en) | 2018-08-02 |
| BE1022792B1 (fr) | 2016-09-06 |
| EA201790239A1 (ru) | 2017-07-31 |
| BR112017002183A2 (pt) | 2018-01-16 |
| BE1022792A1 (fr) | 2016-09-06 |
| EP3177324A1 (en) | 2017-06-14 |
| ZA201700824B (en) | 2019-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20200831 |