CA2953641C - Novel formulation and method of synthesis - Google Patents
Novel formulation and method of synthesis Download PDFInfo
- Publication number
- CA2953641C CA2953641C CA2953641A CA2953641A CA2953641C CA 2953641 C CA2953641 C CA 2953641C CA 2953641 A CA2953641 A CA 2953641A CA 2953641 A CA2953641 A CA 2953641A CA 2953641 C CA2953641 C CA 2953641C
- Authority
- CA
- Canada
- Prior art keywords
- reaction mixture
- facbc
- acid
- formula
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1411569.5A GB201411569D0 (en) | 2014-06-30 | 2014-06-30 | Novel formulation and method of synthesis |
| GB1411569.5 | 2014-06-30 | ||
| PCT/EP2015/064796 WO2016001199A1 (en) | 2014-06-30 | 2015-06-30 | Novel formulation and method of synthesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2953641A1 CA2953641A1 (en) | 2016-01-07 |
| CA2953641C true CA2953641C (en) | 2022-09-13 |
Family
ID=51410328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2953641A Active CA2953641C (en) | 2014-06-30 | 2015-06-30 | Novel formulation and method of synthesis |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11077216B2 (https=) |
| EP (2) | EP3160923B1 (https=) |
| JP (3) | JP6997519B2 (https=) |
| KR (1) | KR102381616B1 (https=) |
| CN (1) | CN106458785B (https=) |
| AU (1) | AU2015283054B2 (https=) |
| BR (1) | BR112016030350B1 (https=) |
| CA (1) | CA2953641C (https=) |
| DK (1) | DK3431460T3 (https=) |
| ES (1) | ES2710073T3 (https=) |
| GB (1) | GB201411569D0 (https=) |
| IL (1) | IL249348A0 (https=) |
| PL (1) | PL3160923T3 (https=) |
| PT (1) | PT3160923T (https=) |
| RU (1) | RU2016147507A (https=) |
| SG (1) | SG11201610883QA (https=) |
| TR (1) | TR201901460T4 (https=) |
| WO (1) | WO2016001199A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220001034A1 (en) * | 2014-06-30 | 2022-01-06 | Ge Healthcare Limited | Novel formulation and method of synthesis |
| US12180581B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709155B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709156B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved analytical analysis |
| US12181452B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| GB201805253D0 (en) | 2018-03-29 | 2018-05-16 | Ge Healthcare Ltd Ip | Solid phase extraction |
| GB201915206D0 (en) | 2019-10-21 | 2019-12-04 | Ge Healthcare Ltd | Use of cyclodextrins as a radiostabilizer |
| US11918936B2 (en) | 2020-01-17 | 2024-03-05 | Waters Technologies Corporation | Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding |
| US12352734B2 (en) | 2020-09-24 | 2025-07-08 | Waters Technologies Corporation | Chromatographic hardware improvements for separation of reactive molecules |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1356827A1 (en) | 2002-04-24 | 2003-10-29 | Mallinckrodt Inc. | Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution |
| US7993626B2 (en) | 2007-01-11 | 2011-08-09 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
| CA2526556C (en) | 2003-07-24 | 2012-09-25 | Bracco Imaging S.P.A. | Stable radiopharmaceutical compositions and methods for their preparation |
| GB0422004D0 (en) | 2004-10-05 | 2004-11-03 | Amersham Plc | Method of deprotection |
| US20060292073A1 (en) | 2005-06-23 | 2006-12-28 | Emory University | Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging |
| PL1978015T3 (pl) | 2005-11-29 | 2018-07-31 | Nihon Medi-Physics Co., Ltd. | Związek prekursorowy związku organicznego znakowanego radioaktywnym halogenem |
| NZ572936A (en) | 2006-05-11 | 2011-01-28 | Nihon Mediphysics Co Ltd | Process for production of [18F]1-amino-3-fluorocyclobutanecarboxylic acid, [18F]FACBC |
| PL2106808T3 (pl) | 2006-12-21 | 2018-07-31 | Nihon Medi-Physics Co., Ltd. | Promieniotwórczy znacznik do obrazowania diagnostycznego zawierający kwas 1-amino-3-[18F]fluorocyklobutanokarboksylowy |
| TWI406674B (zh) | 2007-02-13 | 2013-09-01 | 日本藥學物理公司 | Method for manufacturing diagnostic radiographic diagnostic agents |
| CA2823063C (en) | 2010-12-29 | 2020-08-11 | Ge Healthcare Limited | A method for preparation of f for use in a radiofluorination reaction |
| GB201117785D0 (en) | 2011-10-14 | 2011-11-30 | Ge Healthcare Ltd | Improved radiosynthesis method |
| KR20140102700A (ko) * | 2011-12-21 | 2014-08-22 | 지이 헬쓰케어 리미티드 | 시트레이트 완충제 내 18ｆ―플루시클로빈 조성물 |
| GB201205703D0 (en) | 2012-03-30 | 2012-05-16 | Ge Healthcare Ltd | Synthon composition |
| GB201214220D0 (en) * | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
-
2014
- 2014-06-30 GB GBGB1411569.5A patent/GB201411569D0/en not_active Ceased
-
2015
- 2015-06-30 AU AU2015283054A patent/AU2015283054B2/en active Active
- 2015-06-30 PL PL15732267T patent/PL3160923T3/pl unknown
- 2015-06-30 JP JP2016573925A patent/JP6997519B2/ja active Active
- 2015-06-30 PT PT15732267T patent/PT3160923T/pt unknown
- 2015-06-30 EP EP15732267.8A patent/EP3160923B1/en active Active
- 2015-06-30 TR TR2019/01460T patent/TR201901460T4/tr unknown
- 2015-06-30 SG SG11201610883QA patent/SG11201610883QA/en unknown
- 2015-06-30 KR KR1020167036497A patent/KR102381616B1/ko active Active
- 2015-06-30 ES ES15732267T patent/ES2710073T3/es active Active
- 2015-06-30 EP EP18187551.9A patent/EP3431460B1/en active Active
- 2015-06-30 CN CN201580035646.6A patent/CN106458785B/zh active Active
- 2015-06-30 CA CA2953641A patent/CA2953641C/en active Active
- 2015-06-30 DK DK18187551.9T patent/DK3431460T3/da active
- 2015-06-30 RU RU2016147507A patent/RU2016147507A/ru unknown
- 2015-06-30 US US15/318,599 patent/US11077216B2/en active Active
- 2015-06-30 WO PCT/EP2015/064796 patent/WO2016001199A1/en not_active Ceased
- 2015-06-30 BR BR112016030350-4A patent/BR112016030350B1/pt active IP Right Grant
-
2016
- 2016-12-01 IL IL249348A patent/IL249348A0/en active IP Right Grant
-
2020
- 2020-07-02 JP JP2020114659A patent/JP2020172518A/ja active Pending
-
2022
- 2022-06-13 JP JP2022095283A patent/JP7657759B2/ja active Active
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200622 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 10TH ANNIV.) - STANDARD Year of fee payment: 10 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250527 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250527 |