DK3431460T3 - Ny formulering og fremgangsmåde til syntese - Google Patents

Ny formulering og fremgangsmåde til syntese Download PDF

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Publication number
DK3431460T3
DK3431460T3 DK18187551.9T DK18187551T DK3431460T3 DK 3431460 T3 DK3431460 T3 DK 3431460T3 DK 18187551 T DK18187551 T DK 18187551T DK 3431460 T3 DK3431460 T3 DK 3431460T3
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DK
Denmark
Prior art keywords
synthesis
procedure
new formulation
formulation
new
Prior art date
Application number
DK18187551.9T
Other languages
English (en)
Inventor
Torild Wickstrom
Knut Richard Dyrstad
Thanushan Rajanayagam
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of DK3431460T3 publication Critical patent/DK3431460T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001Acyclic or carbocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0402Organic compounds carboxylic acid carriers, fatty acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK18187551.9T 2014-06-30 2015-06-30 Ny formulering og fremgangsmåde til syntese DK3431460T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1411569.5A GB201411569D0 (en) 2014-06-30 2014-06-30 Novel formulation and method of synthesis
EP15732267.8A EP3160923B1 (en) 2014-06-30 2015-06-30 Novel formulation and method of synthesis

Publications (1)

Publication Number Publication Date
DK3431460T3 true DK3431460T3 (da) 2021-05-10

Family

ID=51410328

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18187551.9T DK3431460T3 (da) 2014-06-30 2015-06-30 Ny formulering og fremgangsmåde til syntese

Country Status (18)

Country Link
US (1) US11077216B2 (da)
EP (2) EP3431460B1 (da)
JP (3) JP6997519B2 (da)
KR (1) KR102381616B1 (da)
CN (1) CN106458785B (da)
AU (1) AU2015283054B2 (da)
BR (1) BR112016030350B1 (da)
CA (1) CA2953641C (da)
DK (1) DK3431460T3 (da)
ES (1) ES2710073T3 (da)
GB (1) GB201411569D0 (da)
IL (1) IL249348A0 (da)
PL (1) PL3160923T3 (da)
PT (1) PT3160923T (da)
RU (1) RU2016147507A (da)
SG (1) SG11201610883QA (da)
TR (1) TR201901460T4 (da)
WO (1) WO2016001199A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220001034A1 (en) * 2014-06-30 2022-01-06 Ge Healthcare Limited Novel formulation and method of synthesis
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
GB201805253D0 (en) * 2018-03-29 2018-05-16 Ge Healthcare Ltd Ip Solid phase extraction
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1356827A1 (en) 2002-04-24 2003-10-29 Mallinckrodt Inc. Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution
US7993626B2 (en) 2007-01-11 2011-08-09 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
CA2783275A1 (en) 2003-07-24 2005-02-03 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
GB0422004D0 (en) 2004-10-05 2004-11-03 Amersham Plc Method of deprotection
EP1893246A4 (en) 2005-06-23 2009-05-06 Univ Emory STEREOSELECTIVE SYNTHESIS OF AMINO ACID ANALOGUE FOR TUMOR IMAGING
KR20080071146A (ko) 2005-11-29 2008-08-01 니혼 메디피직스 가부시키가이샤 방사성 할로겐 표식 유기 화합물의 전구체 화합물
CA2651786C (en) 2006-05-11 2014-11-04 Nihon Medi-Physics Co., Ltd. Process for production of radioactive fluorine-labeled organic compound
PL2106808T3 (pl) 2006-12-21 2018-07-31 Nihon Medi-Physics Co., Ltd. Promieniotwórczy znacznik do obrazowania diagnostycznego zawierający kwas 1-amino-3-[18F]fluorocyklobutanokarboksylowy
CN101636183B (zh) 2007-02-13 2014-03-19 日本医事物理股份有限公司 放射性诊断显像剂的制备方法
CN108218650A (zh) 2010-12-29 2018-06-29 通用电气健康护理有限公司 洗脱溶液
EP2793954B1 (en) * 2011-12-21 2020-10-21 GE Healthcare Limited 18f-fluciclovine compositions in citrate buffers
GB201117785D0 (en) 2011-10-14 2011-11-30 Ge Healthcare Ltd Improved radiosynthesis method
GB201205703D0 (en) 2012-03-30 2012-05-16 Ge Healthcare Ltd Synthon composition
GB201214220D0 (en) 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis

Also Published As

Publication number Publication date
JP2017520550A (ja) 2017-07-27
EP3431460A3 (en) 2019-02-20
WO2016001199A1 (en) 2016-01-07
TR201901460T4 (tr) 2019-02-21
CA2953641A1 (en) 2016-01-07
EP3431460B1 (en) 2021-02-17
JP2022136074A (ja) 2022-09-15
AU2015283054A1 (en) 2016-12-08
JP6997519B2 (ja) 2022-02-04
US11077216B2 (en) 2021-08-03
EP3160923B1 (en) 2019-01-02
BR112016030350A2 (da) 2017-08-22
KR102381616B1 (ko) 2022-04-01
AU2015283054B2 (en) 2017-11-23
JP2020172518A (ja) 2020-10-22
GB201411569D0 (en) 2014-08-13
KR20170027732A (ko) 2017-03-10
PT3160923T (pt) 2019-02-12
US20170128597A1 (en) 2017-05-11
RU2016147507A3 (da) 2019-01-18
EP3160923A1 (en) 2017-05-03
CN106458785A (zh) 2017-02-22
EP3431460A2 (en) 2019-01-23
RU2016147507A (ru) 2018-07-30
CN106458785B (zh) 2020-10-09
SG11201610883QA (en) 2017-01-27
ES2710073T3 (es) 2019-04-22
BR112016030350B1 (pt) 2024-01-30
IL249348A0 (en) 2017-02-28
NZ727574A (en) 2023-11-24
CA2953641C (en) 2022-09-13
PL3160923T3 (pl) 2019-06-28

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