CA2952443C - Dimeric 1-arylpyrazole derivatives - Google Patents
Dimeric 1-arylpyrazole derivatives Download PDFInfo
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- CA2952443C CA2952443C CA2952443A CA2952443A CA2952443C CA 2952443 C CA2952443 C CA 2952443C CA 2952443 A CA2952443 A CA 2952443A CA 2952443 A CA2952443 A CA 2952443A CA 2952443 C CA2952443 C CA 2952443C
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- independently selected
- alkyl
- spp
- haloalkyl
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- 125000004961 1-arylpyrazolyl group Chemical group 0.000 title abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 184
- 239000000203 mixture Substances 0.000 claims abstract description 183
- -1 for example Substances 0.000 claims abstract description 153
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- 125000000217 alkyl group Chemical group 0.000 claims description 210
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 156
- 125000001188 haloalkyl group Chemical group 0.000 claims description 145
- 229910052736 halogen Inorganic materials 0.000 claims description 130
- 150000002367 halogens Chemical class 0.000 claims description 130
- 125000003118 aryl group Chemical group 0.000 claims description 122
- 125000001072 heteroaryl group Chemical group 0.000 claims description 117
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 105
- 229910052739 hydrogen Inorganic materials 0.000 claims description 97
- 125000003342 alkenyl group Chemical group 0.000 claims description 96
- 125000000304 alkynyl group Chemical group 0.000 claims description 94
- 239000001257 hydrogen Substances 0.000 claims description 68
- 125000003545 alkoxy group Chemical group 0.000 claims description 67
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- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 2
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- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Agronomy & Crop Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
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| US11602108P | 2008-11-19 | 2008-11-19 | |
| US61/116,021 | 2008-11-19 | ||
| CA2743553A CA2743553C (en) | 2008-11-19 | 2009-11-18 | Dimeric 1-arylpyrazole derivatives |
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| CA2743553A Division CA2743553C (en) | 2008-11-19 | 2009-11-18 | Dimeric 1-arylpyrazole derivatives |
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| CA2952443A1 CA2952443A1 (en) | 2010-05-27 |
| CA2952443C true CA2952443C (en) | 2019-04-02 |
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| CA2952443A Active CA2952443C (en) | 2008-11-19 | 2009-11-18 | Dimeric 1-arylpyrazole derivatives |
| CA2743553A Active CA2743553C (en) | 2008-11-19 | 2009-11-18 | Dimeric 1-arylpyrazole derivatives |
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| CA2743553A Active CA2743553C (en) | 2008-11-19 | 2009-11-18 | Dimeric 1-arylpyrazole derivatives |
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| CA2891334C (en) | 2012-11-13 | 2021-10-19 | Array Biopharma Inc. | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain |
| WO2014078328A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| RU2677667C2 (ru) | 2012-11-13 | 2019-01-18 | Эррэй Биофарма Инк. | Соединения n-пирролидинилмочевины, n'-пиразолилмочевины, тиомочевины, гуанидина и цианогуанидина как ингибиторы киназы trka |
| WO2014078322A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| US9790210B2 (en) | 2012-11-13 | 2017-10-17 | Array Biopharma Inc. | N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
| WO2014078331A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| WO2014078417A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
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| US9790178B2 (en) | 2012-11-13 | 2017-10-17 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
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| JP2016164125A (ja) * | 2013-07-02 | 2016-09-08 | 国立大学法人帯広畜産大学 | バベシア症の治療剤及び予防剤 |
| RU2719489C2 (ru) | 2014-05-15 | 2020-04-17 | Эррэй Биофарма Инк. | 1-((3S,4R)-4-(3-ФТОРФЕНИЛ)-1-(2-МЕТОКСИЭТИЛ)ПИРРОЛИДИН-3-ИЛ)-3-(4-МЕТИЛ-3-(2-МЕТИЛПИРИМИДИН-5-ИЛ)-1-ФЕНИЛ-1Н-ПИРАЗОЛ-5-ИЛ)МОЧЕВИНА В КАЧЕСТВЕ ИНГИБИТОРА TrkA КИНАЗЫ |
| WO2017195173A1 (en) | 2016-05-12 | 2017-11-16 | Verdesian Life Sciences, U.S., Llc | Compositions for controlling enzyme-induced urea decomposition |
| MY201375A (en) | 2017-03-28 | 2024-02-20 | Verdesian Life Sciences Us Llc | Triarylmethane compounds for controlling enzyme-induced urea decomposition |
| JP7504882B2 (ja) | 2018-11-06 | 2024-06-24 | コルテバ アグリサイエンス エルエルシー | ピリジンカルボン酸エステル除草剤とクロキントセットとを含む薬害が軽減された組成物 |
| ES3013124T3 (en) * | 2018-11-06 | 2025-04-11 | Corteva Agriscience Llc | Compositions comprising pyridine carboxylate herbicides and azole carboxylate safeners |
| WO2020096936A1 (en) | 2018-11-07 | 2020-05-14 | Dow Agrosciences Llc | Compositions comprising pyridine carboxylate herbicides and 4-hydroxyphenyl-pyruvate dioxygenase (hppd) inhibitor herbicides |
| PL3876733T3 (pl) | 2018-11-07 | 2025-11-03 | Corteva Agriscience Llc | Kompozycje zawierające herbicydy pirydynokarboksylanowe z herbicydami jako inhibitorami fotosystemu ii i opcjonalnie herbicydami jako inhibitorami hppd |
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| AU784798B2 (en) * | 1999-12-02 | 2006-06-22 | Boehringer Ingelheim Animal Health USA Inc. | Control of arthropods in animals |
| US7262214B2 (en) * | 2003-02-26 | 2007-08-28 | Merial Limited | 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases |
| MX2007000158A (es) * | 2004-06-26 | 2007-10-10 | Bayer Cropscience Sa | Derivados de n-fenilpirazol como pesticidas. |
-
2009
- 2009-11-18 AU AU2009316710A patent/AU2009316710B2/en active Active
- 2009-11-18 MX MX2011005214A patent/MX2011005214A/es active IP Right Grant
- 2009-11-18 CN CN2009801525502A patent/CN102264706A/zh active Pending
- 2009-11-18 EP EP09756226.8A patent/EP2364300B1/en active Active
- 2009-11-18 CA CA2952443A patent/CA2952443C/en active Active
- 2009-11-18 BR BRPI0922042A patent/BRPI0922042B1/pt active IP Right Grant
- 2009-11-18 ES ES09756226.8T patent/ES2605811T3/es active Active
- 2009-11-18 JP JP2011537582A patent/JP2012509338A/ja active Pending
- 2009-11-18 US US13/129,031 patent/US8642636B2/en active Active
- 2009-11-18 NZ NZ592985A patent/NZ592985A/xx unknown
- 2009-11-18 WO PCT/US2009/064981 patent/WO2010059719A2/en not_active Ceased
- 2009-11-18 CA CA2743553A patent/CA2743553C/en active Active
- 2009-11-18 EA EA201100800A patent/EA020923B1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0922042A2 (pt) | 2016-11-01 |
| CA2743553A1 (en) | 2010-05-27 |
| CN102264706A (zh) | 2011-11-30 |
| EP2364300A2 (en) | 2011-09-14 |
| AU2009316710B2 (en) | 2015-08-06 |
| WO2010059719A3 (en) | 2010-11-18 |
| HK1160852A1 (en) | 2012-08-17 |
| EA020923B1 (ru) | 2015-02-27 |
| CA2743553C (en) | 2017-03-14 |
| EP2364300B1 (en) | 2016-10-19 |
| ES2605811T3 (es) | 2017-03-16 |
| US20110245157A1 (en) | 2011-10-06 |
| BRPI0922042B1 (pt) | 2020-01-28 |
| WO2010059719A2 (en) | 2010-05-27 |
| AU2009316710A1 (en) | 2010-05-27 |
| EA201100800A1 (ru) | 2011-12-30 |
| JP2012509338A (ja) | 2012-04-19 |
| CA2952443A1 (en) | 2010-05-27 |
| US8642636B2 (en) | 2014-02-04 |
| NZ592985A (en) | 2013-04-26 |
| MX2011005214A (es) | 2011-06-01 |
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