MX2011005214A - Derivados de 1-arilpirazol dimericos. - Google Patents
Derivados de 1-arilpirazol dimericos.Info
- Publication number
- MX2011005214A MX2011005214A MX2011005214A MX2011005214A MX2011005214A MX 2011005214 A MX2011005214 A MX 2011005214A MX 2011005214 A MX2011005214 A MX 2011005214A MX 2011005214 A MX2011005214 A MX 2011005214A MX 2011005214 A MX2011005214 A MX 2011005214A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- independently selected
- alkyl
- haloalkyl
- halogen
- Prior art date
Links
- 125000004961 1-arylpyrazolyl group Chemical group 0.000 title description 9
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- -1 for example Substances 0.000 claims abstract description 162
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- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
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- 150000003918 triazines Chemical class 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical compound BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- QIWRFOJWQSSRJZ-UHFFFAOYSA-N tributyl(ethenyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C=C QIWRFOJWQSSRJZ-UHFFFAOYSA-N 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
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- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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- 229960003223 tripelennamine Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
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- 150000003672 ureas Chemical class 0.000 description 1
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- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 229940045605 vanadium Drugs 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 229960004298 vecuronium bromide Drugs 0.000 description 1
- VEPSYABRBFXYIB-PWXDFCLTSA-M vecuronium bromide Chemical compound [Br-].N1([C@@H]2[C@@H](OC(C)=O)C[C@@H]3CC[C@H]4[C@@H]5C[C@@H]([C@@H]([C@]5(CC[C@@H]4[C@@]3(C)C2)C)OC(=O)C)[N+]2(C)CCCCC2)CCCCC1 VEPSYABRBFXYIB-PWXDFCLTSA-M 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 229960004982 vinblastine sulfate Drugs 0.000 description 1
- KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
- AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical compound OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 229960002647 warfarin sodium Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000001238 wet grinding Methods 0.000 description 1
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- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
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- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001366 zolazepam Drugs 0.000 description 1
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 description 1
- 229960002911 zonisamide Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Agronomy & Crop Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11602108P | 2008-11-19 | 2008-11-19 | |
| PCT/US2009/064981 WO2010059719A2 (en) | 2008-11-19 | 2009-11-18 | Dimeric 1-arylpyrazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011005214A true MX2011005214A (es) | 2011-06-01 |
Family
ID=42034586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011005214A MX2011005214A (es) | 2008-11-19 | 2009-11-18 | Derivados de 1-arilpirazol dimericos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8642636B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2364300B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2012509338A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102264706A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009316710B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0922042B1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2952443C (cg-RX-API-DMAC7.html) |
| EA (1) | EA020923B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2605811T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011005214A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ592985A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010059719A2 (cg-RX-API-DMAC7.html) |
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| BR112013029201B1 (pt) | 2011-05-13 | 2022-08-09 | Array Biopharma Inc | Compostos de pirrolidinil ureia e pirrolidinil tioureia, seu processo de preparação, seu uso e composições farmacêuticas |
| CA2891334C (en) | 2012-11-13 | 2021-10-19 | Array Biopharma Inc. | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain |
| WO2014078328A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| RU2677667C2 (ru) | 2012-11-13 | 2019-01-18 | Эррэй Биофарма Инк. | Соединения n-пирролидинилмочевины, n'-пиразолилмочевины, тиомочевины, гуанидина и цианогуанидина как ингибиторы киназы trka |
| WO2014078322A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| US9790210B2 (en) | 2012-11-13 | 2017-10-17 | Array Biopharma Inc. | N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
| WO2014078331A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| WO2014078417A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| WO2014078408A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| US9790178B2 (en) | 2012-11-13 | 2017-10-17 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
| WO2014078378A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| JP2016164125A (ja) * | 2013-07-02 | 2016-09-08 | 国立大学法人帯広畜産大学 | バベシア症の治療剤及び予防剤 |
| RU2719489C2 (ru) | 2014-05-15 | 2020-04-17 | Эррэй Биофарма Инк. | 1-((3S,4R)-4-(3-ФТОРФЕНИЛ)-1-(2-МЕТОКСИЭТИЛ)ПИРРОЛИДИН-3-ИЛ)-3-(4-МЕТИЛ-3-(2-МЕТИЛПИРИМИДИН-5-ИЛ)-1-ФЕНИЛ-1Н-ПИРАЗОЛ-5-ИЛ)МОЧЕВИНА В КАЧЕСТВЕ ИНГИБИТОРА TrkA КИНАЗЫ |
| WO2017195173A1 (en) | 2016-05-12 | 2017-11-16 | Verdesian Life Sciences, U.S., Llc | Compositions for controlling enzyme-induced urea decomposition |
| MY201375A (en) | 2017-03-28 | 2024-02-20 | Verdesian Life Sciences Us Llc | Triarylmethane compounds for controlling enzyme-induced urea decomposition |
| JP7504882B2 (ja) | 2018-11-06 | 2024-06-24 | コルテバ アグリサイエンス エルエルシー | ピリジンカルボン酸エステル除草剤とクロキントセットとを含む薬害が軽減された組成物 |
| ES3013124T3 (en) * | 2018-11-06 | 2025-04-11 | Corteva Agriscience Llc | Compositions comprising pyridine carboxylate herbicides and azole carboxylate safeners |
| WO2020096936A1 (en) | 2018-11-07 | 2020-05-14 | Dow Agrosciences Llc | Compositions comprising pyridine carboxylate herbicides and 4-hydroxyphenyl-pyruvate dioxygenase (hppd) inhibitor herbicides |
| PL3876733T3 (pl) | 2018-11-07 | 2025-11-03 | Corteva Agriscience Llc | Kompozycje zawierające herbicydy pirydynokarboksylanowe z herbicydami jako inhibitorami fotosystemu ii i opcjonalnie herbicydami jako inhibitorami hppd |
| ES3037961T3 (en) | 2018-11-07 | 2025-10-08 | Corteva Agriscience Llc | Compositions comprising pyridine carboxylate herbicides with acetolactate synthase (als) inhibitor herbicides |
| CA3118677A1 (en) | 2018-11-07 | 2020-05-14 | Corteva Agriscience Llc | Compositions comprising a pyridine carboxylate herbicide and protoporphyrinogen oxidase (protox) inhibitor herbicides |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| EP4185585A1 (en) | 2020-07-24 | 2023-05-31 | Elanco Us Inc. | Process for making an isoxazoline compound and intermediate thereof |
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| US3966900A (en) * | 1969-03-12 | 1976-06-29 | Airwick Industries, Inc. | Evaporator system comprising a stabilized pesticidal phosphoric acid ester and method for stabilizing such ester enclosed in an evaporator |
| AU784798B2 (en) * | 1999-12-02 | 2006-06-22 | Boehringer Ingelheim Animal Health USA Inc. | Control of arthropods in animals |
| US7262214B2 (en) * | 2003-02-26 | 2007-08-28 | Merial Limited | 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases |
| MX2007000158A (es) * | 2004-06-26 | 2007-10-10 | Bayer Cropscience Sa | Derivados de n-fenilpirazol como pesticidas. |
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2009
- 2009-11-18 AU AU2009316710A patent/AU2009316710B2/en active Active
- 2009-11-18 MX MX2011005214A patent/MX2011005214A/es active IP Right Grant
- 2009-11-18 CN CN2009801525502A patent/CN102264706A/zh active Pending
- 2009-11-18 EP EP09756226.8A patent/EP2364300B1/en active Active
- 2009-11-18 CA CA2952443A patent/CA2952443C/en active Active
- 2009-11-18 BR BRPI0922042A patent/BRPI0922042B1/pt active IP Right Grant
- 2009-11-18 ES ES09756226.8T patent/ES2605811T3/es active Active
- 2009-11-18 JP JP2011537582A patent/JP2012509338A/ja active Pending
- 2009-11-18 US US13/129,031 patent/US8642636B2/en active Active
- 2009-11-18 NZ NZ592985A patent/NZ592985A/xx unknown
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- 2009-11-18 CA CA2743553A patent/CA2743553C/en active Active
- 2009-11-18 EA EA201100800A patent/EA020923B1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0922042A2 (pt) | 2016-11-01 |
| CA2743553A1 (en) | 2010-05-27 |
| CN102264706A (zh) | 2011-11-30 |
| EP2364300A2 (en) | 2011-09-14 |
| AU2009316710B2 (en) | 2015-08-06 |
| WO2010059719A3 (en) | 2010-11-18 |
| CA2952443C (en) | 2019-04-02 |
| HK1160852A1 (en) | 2012-08-17 |
| EA020923B1 (ru) | 2015-02-27 |
| CA2743553C (en) | 2017-03-14 |
| EP2364300B1 (en) | 2016-10-19 |
| ES2605811T3 (es) | 2017-03-16 |
| US20110245157A1 (en) | 2011-10-06 |
| BRPI0922042B1 (pt) | 2020-01-28 |
| WO2010059719A2 (en) | 2010-05-27 |
| AU2009316710A1 (en) | 2010-05-27 |
| EA201100800A1 (ru) | 2011-12-30 |
| JP2012509338A (ja) | 2012-04-19 |
| CA2952443A1 (en) | 2010-05-27 |
| US8642636B2 (en) | 2014-02-04 |
| NZ592985A (en) | 2013-04-26 |
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