CA2950640A1 - Cerdulatinib for treating hematological cancers - Google Patents
Cerdulatinib for treating hematological cancers Download PDFInfo
- Publication number
- CA2950640A1 CA2950640A1 CA2950640A CA2950640A CA2950640A1 CA 2950640 A1 CA2950640 A1 CA 2950640A1 CA 2950640 A CA2950640 A CA 2950640A CA 2950640 A CA2950640 A CA 2950640A CA 2950640 A1 CA2950640 A1 CA 2950640A1
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- CA
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- Prior art keywords
- cerdulatinib
- pharmaceutically acceptable
- patient
- acceptable salt
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Chemical Kinetics & Catalysis (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201662342755P | 2016-05-27 | 2016-05-27 | |
| US201662342727P | 2016-05-27 | 2016-05-27 | |
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| US201662371145P | 2016-08-04 | 2016-08-04 | |
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| JP7258462B2 (ja) | 2015-05-29 | 2023-04-17 | ポートラ ファーマシューティカルズ， エルエルシー | Ｂ細胞悪性腫瘍の治療のためのセルデュラチニブ |
| JP6833816B2 (ja) | 2015-08-12 | 2021-02-24 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 骨髄腫を治療するためのセルデュラチニブ（ｃｅｒｄｕｌａｔｉｎｉｂ） |
| RU2020124293A (ru) * | 2018-01-09 | 2022-02-10 | Дермавант Саенсиз Гмбх | Фармацевтические композиции для местного нанесения на кожу, содержащие цердулатиниб, и их применение |
| JP2021523114A (ja) * | 2018-05-04 | 2021-09-02 | ポートラ ファーマシューティカルズ， インコーポレイテッド | リンパ腫の治療方法 |
| US10865198B2 (en) | 2018-05-04 | 2020-12-15 | Alexion Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
| US10851087B2 (en) | 2018-05-04 | 2020-12-01 | Portola Pharmaceuticals, Inc. | Synthesis of cerdulatinib |
| SG11202108770TA (en) * | 2019-02-15 | 2021-09-29 | Janssen Biotech Inc | Combination therapy for treatment of b-cell malignancies |
| JP2023529313A (ja) * | 2020-05-26 | 2023-07-10 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 低悪性度ｂ細胞リンパ腫における循環ｂ細胞亜集団 |
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| WO1999031073A1 (en) | 1997-12-15 | 1999-06-24 | Yamanouchi Pharmaceutical Co., Ltd. | Novel pyrimidine-5-carboxamide derivatives |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| US7449456B2 (en) | 2002-06-28 | 2008-11-11 | Astellas Pharma, Inc. | Diaminopyrimidinecarboxamide derivative |
| JP2009544592A (ja) | 2006-07-21 | 2009-12-17 | ノバルティス アクチエンゲゼルシャフト | Ｊａｋキナーゼ阻害剤としての２，４−ジ（アリールアミノ）−ピリミジン−５−カルボキサミド化合物 |
| ES2616789T3 (es) | 2006-09-22 | 2017-06-14 | Pharmacyclics, Inc. | Inhibidores de tirosina cinasa de Bruton |
| CA2960692C (en) | 2008-04-16 | 2019-09-24 | Portola Pharmaceuticals, Inc. | 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| AR076550A1 (es) | 2009-05-06 | 2011-06-22 | Portola Pharm Inc | Inhibidores de la janus tirosina kinasa (jak) |
| PL2435432T6 (pl) | 2009-05-26 | 2024-02-12 | Abbvie Ireland Unlimited Company | Środki wywołujące apoptozę do leczenia raka oraz chorób immunologicznych i autoimmunologicznych |
| CA2780759A1 (en) | 2009-12-01 | 2011-06-09 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| US9357229B2 (en) | 2010-07-28 | 2016-05-31 | Qualcomm Incorporated | Coding motion vectors in video coding |
| EP2621489A1 (en) | 2010-09-30 | 2013-08-07 | Portola Pharmaceuticals, Inc. | Combinations of 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide and fludarabine |
| SI2643322T1 (en) | 2010-11-23 | 2018-01-31 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| CA2844507A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Jak pi3k/mtor combination therapy |
| BR112015001690A2 (pt) | 2012-07-24 | 2017-11-07 | Pharmacyclics Inc | mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk) |
| EP2903970A4 (en) | 2012-10-08 | 2016-11-30 | Portola Pharm Inc | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS |
| CA2890111A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| JP7258462B2 (ja) | 2015-05-29 | 2023-04-17 | ポートラ ファーマシューティカルズ， エルエルシー | Ｂ細胞悪性腫瘍の治療のためのセルデュラチニブ |
| JP6833816B2 (ja) | 2015-08-12 | 2021-02-24 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 骨髄腫を治療するためのセルデュラチニブ（ｃｅｒｄｕｌａｔｉｎｉｂ） |
| US10865198B2 (en) | 2018-05-04 | 2020-12-15 | Alexion Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
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2016
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- 2016-12-02 WO PCT/US2016/064824 patent/WO2017096303A2/en not_active Ceased
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2020
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Also Published As
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|---|---|
| CN108367006A (zh) | 2018-08-03 |
| US11446300B2 (en) | 2022-09-20 |
| WO2017096303A3 (en) | 2017-08-03 |
| US10736895B2 (en) | 2020-08-11 |
| EP3383396B1 (en) | 2023-07-12 |
| CN108367006B (zh) | 2021-12-31 |
| WO2017096303A2 (en) | 2017-06-08 |
| JP6944936B2 (ja) | 2021-10-06 |
| EP3383396A2 (en) | 2018-10-10 |
| ES2959692T3 (es) | 2024-02-27 |
| AU2016363005A1 (en) | 2018-07-05 |
| US20210000827A1 (en) | 2021-01-07 |
| US20180353506A1 (en) | 2018-12-13 |
| JP2018535996A (ja) | 2018-12-06 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20230223 |
|
| FZDE | Discontinued |
Effective date: 20230223 |