JP6944936B2 - 血液癌を処置するためのセルデュラチニブ - Google Patents

血液癌を処置するためのセルデュラチニブ Download PDF

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JP6944936B2
JP6944936B2 JP2018528591A JP2018528591A JP6944936B2 JP 6944936 B2 JP6944936 B2 JP 6944936B2 JP 2018528591 A JP2018528591 A JP 2018528591A JP 2018528591 A JP2018528591 A JP 2018528591A JP 6944936 B2 JP6944936 B2 JP 6944936B2
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cerduratinib
pharmaceutically acceptable
acceptable salt
administered
patient
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JP2018535996A5 (cg-RX-API-DMAC7.html
JP2018535996A (ja
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グレゴリー コフィー，
グレゴリー コフィー，
ジャジャ フェン，
ジャジャ フェン，
アンドリュー スティール，
アンドリュー スティール，
Original Assignee
ポートラ ファーマシューティカルズ， インコーポレイテッド
ポートラ ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018528591A 2015-12-04 2016-12-02 血液癌を処置するためのセルデュラチニブ Expired - Fee Related JP6944936B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562263582P 2015-12-04 2015-12-04
US62/263,582 2015-12-04
US201662342755P 2016-05-27 2016-05-27
US201662342727P 2016-05-27 2016-05-27
US62/342,755 2016-05-27
US62/342,727 2016-05-27
US201662371145P 2016-08-04 2016-08-04
US62/371,145 2016-08-04
PCT/US2016/064824 WO2017096303A2 (en) 2015-12-04 2016-12-02 Cerdulatinib for treating hematological cancers

Publications (3)

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JP2018535996A JP2018535996A (ja) 2018-12-06
JP2018535996A5 JP2018535996A5 (cg-RX-API-DMAC7.html) 2020-01-09
JP6944936B2 true JP6944936B2 (ja) 2021-10-06

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JP2018528591A Expired - Fee Related JP6944936B2 (ja) 2015-12-04 2016-12-02 血液癌を処置するためのセルデュラチニブ

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US (2) US10736895B2 (cg-RX-API-DMAC7.html)
EP (1) EP3383396B1 (cg-RX-API-DMAC7.html)
JP (1) JP6944936B2 (cg-RX-API-DMAC7.html)
CN (1) CN108367006B (cg-RX-API-DMAC7.html)
AU (1) AU2016363005A1 (cg-RX-API-DMAC7.html)
CA (1) CA2950640A1 (cg-RX-API-DMAC7.html)
ES (1) ES2959692T3 (cg-RX-API-DMAC7.html)
WO (1) WO2017096303A2 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7258462B2 (ja) 2015-05-29 2023-04-17 ポートラ ファーマシューティカルズ， エルエルシー Ｂ細胞悪性腫瘍の治療のためのセルデュラチニブ
JP6833816B2 (ja) 2015-08-12 2021-02-24 ポートラ ファーマシューティカルズ， インコーポレイテッド 骨髄腫を治療するためのセルデュラチニブ（ｃｅｒｄｕｌａｔｉｎｉｂ）
RU2020124293A (ru) * 2018-01-09 2022-02-10 Дермавант Саенсиз Гмбх Фармацевтические композиции для местного нанесения на кожу, содержащие цердулатиниб, и их применение
JP2021523114A (ja) * 2018-05-04 2021-09-02 ポートラ ファーマシューティカルズ， インコーポレイテッド リンパ腫の治療方法
US10865198B2 (en) 2018-05-04 2020-12-15 Alexion Pharmaceuticals, Inc. Solid forms of cerdulatinib
US10851087B2 (en) 2018-05-04 2020-12-01 Portola Pharmaceuticals, Inc. Synthesis of cerdulatinib
SG11202108770TA (en) * 2019-02-15 2021-09-29 Janssen Biotech Inc Combination therapy for treatment of b-cell malignancies
JP2023529313A (ja) * 2020-05-26 2023-07-10 アレクシオン ファーマシューティカルズ， インコーポレイテッド 低悪性度ｂ細胞リンパ腫における循環ｂ細胞亜集団

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WO1999031073A1 (en) 1997-12-15 1999-06-24 Yamanouchi Pharmaceutical Co., Ltd. Novel pyrimidine-5-carboxamide derivatives
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US7449456B2 (en) 2002-06-28 2008-11-11 Astellas Pharma, Inc. Diaminopyrimidinecarboxamide derivative
JP2009544592A (ja) 2006-07-21 2009-12-17 ノバルティス アクチエンゲゼルシャフト Ｊａｋキナーゼ阻害剤としての２，４−ジ（アリールアミノ）−ピリミジン−５−カルボキサミド化合物
ES2616789T3 (es) 2006-09-22 2017-06-14 Pharmacyclics, Inc. Inhibidores de tirosina cinasa de Bruton
CA2960692C (en) 2008-04-16 2019-09-24 Portola Pharmaceuticals, Inc. 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
AR076550A1 (es) 2009-05-06 2011-06-22 Portola Pharm Inc Inhibidores de la janus tirosina kinasa (jak)
PL2435432T6 (pl) 2009-05-26 2024-02-12 Abbvie Ireland Unlimited Company Środki wywołujące apoptozę do leczenia raka oraz chorób immunologicznych i autoimmunologicznych
CA2780759A1 (en) 2009-12-01 2011-06-09 Rigel Pharmaceuticals, Inc. Protein kinase c inhibitors and uses thereof
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BR112015001690A2 (pt) 2012-07-24 2017-11-07 Pharmacyclics Inc mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk)
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JP6833816B2 (ja) 2015-08-12 2021-02-24 ポートラ ファーマシューティカルズ， インコーポレイテッド 骨髄腫を治療するためのセルデュラチニブ（ｃｅｒｄｕｌａｔｉｎｉｂ）
US10865198B2 (en) 2018-05-04 2020-12-15 Alexion Pharmaceuticals, Inc. Solid forms of cerdulatinib

Also Published As

Publication number Publication date
CN108367006A (zh) 2018-08-03
US11446300B2 (en) 2022-09-20
WO2017096303A3 (en) 2017-08-03
US10736895B2 (en) 2020-08-11
EP3383396B1 (en) 2023-07-12
CN108367006B (zh) 2021-12-31
WO2017096303A2 (en) 2017-06-08
CA2950640A1 (en) 2017-06-04
EP3383396A2 (en) 2018-10-10
ES2959692T3 (es) 2024-02-27
AU2016363005A1 (en) 2018-07-05
US20210000827A1 (en) 2021-01-07
US20180353506A1 (en) 2018-12-13
JP2018535996A (ja) 2018-12-06

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