CA2949982A1 - Anti-lgr5 antibodies and uses thereof - Google Patents
Anti-lgr5 antibodies and uses thereof Download PDFInfo
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- CA2949982A1 CA2949982A1 CA2949982A CA2949982A CA2949982A1 CA 2949982 A1 CA2949982 A1 CA 2949982A1 CA 2949982 A CA2949982 A CA 2949982A CA 2949982 A CA2949982 A CA 2949982A CA 2949982 A1 CA2949982 A1 CA 2949982A1
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- Prior art keywords
- antibody
- seq
- lgr5
- amino acid
- acid sequence
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
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- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201462010637P | 2014-06-11 | 2014-06-11 | |
| US62/010,637 | 2014-06-11 | ||
| PCT/US2015/035111 WO2015191715A1 (en) | 2014-06-11 | 2015-06-10 | Anti-lgr5 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2949982A1 true CA2949982A1 (en) | 2015-12-17 |
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|---|---|---|---|
| CA2949982A Abandoned CA2949982A1 (en) | 2014-06-11 | 2015-06-10 | Anti-lgr5 antibodies and uses thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10316084B2 (enExample) |
| EP (1) | EP3155015A1 (enExample) |
| JP (1) | JP2017526618A (enExample) |
| KR (1) | KR20170010785A (enExample) |
| CN (1) | CN106459202A (enExample) |
| BR (1) | BR112016028838A2 (enExample) |
| CA (1) | CA2949982A1 (enExample) |
| MX (1) | MX2016016233A (enExample) |
| RU (1) | RU2016148616A (enExample) |
| WO (1) | WO2015191715A1 (enExample) |
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| AU2017326751B2 (en) | 2016-09-16 | 2024-10-10 | Bionomics Limited | Antibody and checkpoint inhibitor combination therapy |
| EP3548515A1 (en) | 2016-12-01 | 2019-10-09 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
| BR112019016336A2 (pt) | 2017-02-10 | 2020-03-31 | Regeneron Pharmaceuticals, Inc. | Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto. |
| KR102880156B1 (ko) | 2017-07-24 | 2025-11-05 | 리제너론 파마슈티칼스 인코포레이티드 | 항cd8 항체 및 이의 용도 |
| KR102500434B1 (ko) * | 2019-10-01 | 2023-02-16 | 가톨릭대학교 산학협력단 | 위암의 복강 전이 진단용 펩타이드 프로브 |
| CN120202022A (zh) * | 2022-10-26 | 2025-06-24 | 研究发展基金会 | 细胞靶向构建体及其用途 |
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-
2015
- 2015-06-10 WO PCT/US2015/035111 patent/WO2015191715A1/en not_active Ceased
- 2015-06-10 BR BR112016028838A patent/BR112016028838A2/pt not_active Application Discontinuation
- 2015-06-10 KR KR1020167034257A patent/KR20170010785A/ko not_active Withdrawn
- 2015-06-10 RU RU2016148616A patent/RU2016148616A/ru not_active Application Discontinuation
- 2015-06-10 CN CN201580027888.0A patent/CN106459202A/zh active Pending
- 2015-06-10 JP JP2016572315A patent/JP2017526618A/ja active Pending
- 2015-06-10 CA CA2949982A patent/CA2949982A1/en not_active Abandoned
- 2015-06-10 EP EP15730643.2A patent/EP3155015A1/en not_active Withdrawn
- 2015-06-10 MX MX2016016233A patent/MX2016016233A/es unknown
-
2016
- 2016-11-29 US US15/363,045 patent/US10316084B2/en not_active Expired - Fee Related
-
2019
- 2019-04-22 US US16/390,757 patent/US20190248889A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015191715A1 (en) | 2015-12-17 |
| JP2017526618A (ja) | 2017-09-14 |
| RU2016148616A (ru) | 2018-07-18 |
| MX2016016233A (es) | 2017-03-31 |
| KR20170010785A (ko) | 2017-02-01 |
| CN106459202A (zh) | 2017-02-22 |
| US20170233471A1 (en) | 2017-08-17 |
| US20190248889A1 (en) | 2019-08-15 |
| BR112016028838A2 (pt) | 2017-10-24 |
| EP3155015A1 (en) | 2017-04-19 |
| US10316084B2 (en) | 2019-06-11 |
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