CA2946890A1 - Naphthofuran compounds and compositions for targeting cancer stem cells - Google Patents

Naphthofuran compounds and compositions for targeting cancer stem cells Download PDF

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Publication number
CA2946890A1
CA2946890A1 CA2946890A CA2946890A CA2946890A1 CA 2946890 A1 CA2946890 A1 CA 2946890A1 CA 2946890 A CA2946890 A CA 2946890A CA 2946890 A CA2946890 A CA 2946890A CA 2946890 A1 CA2946890 A1 CA 2946890A1
Authority
CA
Canada
Prior art keywords
cancer
compound
polymorph
degrees
furan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2946890A
Other languages
English (en)
French (fr)
Inventor
Chiang Jia Li
David Leggett
Youzhi Li
Wei Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Oncology Inc
Original Assignee
Boston Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Biomedical Inc filed Critical Boston Biomedical Inc
Priority claimed from CA2793526A external-priority patent/CA2793526C/en
Publication of CA2946890A1 publication Critical patent/CA2946890A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CA2946890A 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells Abandoned CA2946890A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US31589010P 2010-03-19 2010-03-19
US31588610P 2010-03-19 2010-03-19
US61/315,886 2010-03-19
US61/315,890 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029283 WO2011116399A1 (en) 2010-03-19 2011-03-21 Novel methods for targeting cancer stem cells
CA2793526A CA2793526C (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2793526A Division CA2793526C (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Publications (1)

Publication Number Publication Date
CA2946890A1 true CA2946890A1 (en) 2011-09-22

Family

ID=47678420

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2793527A Abandoned CA2793527A1 (en) 2010-03-19 2011-03-21 Use of naphthofuran derivatives in the treatment of cancer
CA2946890A Abandoned CA2946890A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2793527A Abandoned CA2793527A1 (en) 2010-03-19 2011-03-21 Use of naphthofuran derivatives in the treatment of cancer

Country Status (18)

Country Link
US (2) US9730909B2 (enExample)
EP (1) EP2547205B1 (enExample)
JP (1) JP2013522326A (enExample)
CN (1) CN103025159A (enExample)
AU (1) AU2011227023B2 (enExample)
BR (1) BR112012023660B8 (enExample)
CA (2) CA2793527A1 (enExample)
DK (1) DK2547205T3 (enExample)
ES (1) ES2987670T3 (enExample)
FI (1) FI2547205T3 (enExample)
HR (1) HRP20240658T1 (enExample)
LT (1) LT2547205T (enExample)
PL (1) PL2547205T3 (enExample)
RS (1) RS65536B1 (enExample)
RU (1) RU2591823C2 (enExample)
SI (1) SI2547205T1 (enExample)
SM (1) SMT202400193T1 (enExample)
WO (1) WO2011116399A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10377731B2 (en) 2007-09-10 2019-08-13 Boston Biomedical, Inc. Compositions and methods for cancer treatment

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SG11201508358RA (en) * 2013-04-09 2015-11-27 Boston Biomedical Inc 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
CN106163284A (zh) 2014-02-07 2016-11-23 北京强新生物科技有限公司 3‑取代的羰基萘并[2,3‑b]呋喃衍生物或其药学上可接受的盐
EP3153508B1 (en) 2014-06-09 2020-03-18 Kyoto Pharmaceutical Industries, Ltd. Naphthofuran derivatives for use as anticancer agents
EA201792288A1 (ru) 2015-04-17 2018-02-28 Бостон Биомедикал, Инк. Способы лечения рака
AU2016247319A1 (en) 2015-04-17 2017-11-02 Boston Biomedical, Inc. Methods for treating cancer
US20180140572A1 (en) 2015-06-03 2018-05-24 Boston Biomedical, Inc. Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer
JP6871919B2 (ja) 2015-06-16 2021-05-19 ナノファギックス エルエルシー 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
JP2019506392A (ja) 2016-01-20 2019-03-07 ボストン バイオメディカル, インコーポレイテッド がんを処置するための方法
CA3029596A1 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
WO2018102427A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル, インコーポレイテッド がんを処置するための方法
WO2019173648A1 (en) * 2018-03-08 2019-09-12 Exxonmobil Research And Engineering Company Functionalized membranes and methods of production thereof
JP7513286B2 (ja) 2018-10-12 2024-07-09 1グローブ バイオメディカル カンパニー, リミテッド 化学療法難治性がんの治療のための新しい併用薬方法
CN111825644B (zh) * 2019-04-18 2023-07-28 中国医学科学院药物研究所 2,3-二氢萘并[2,3-b]呋喃-4,9-二酮类化合物及其制备方法和用途
CN117350965A (zh) * 2023-10-07 2024-01-05 中国原子能科学研究院 对象内放射性微球的指标预估装置

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10377731B2 (en) 2007-09-10 2019-08-13 Boston Biomedical, Inc. Compositions and methods for cancer treatment

Also Published As

Publication number Publication date
RU2591823C2 (ru) 2016-07-20
JP2013522326A (ja) 2013-06-13
US20170319537A1 (en) 2017-11-09
ES2987670T3 (es) 2024-11-15
HRP20240658T1 (hr) 2024-08-16
FI2547205T3 (fi) 2024-05-27
US9730909B2 (en) 2017-08-15
EP2547205A1 (en) 2013-01-23
RU2012144420A (ru) 2014-04-27
CA2793527A1 (en) 2011-09-22
LT2547205T (lt) 2024-06-10
BR112012023660B1 (pt) 2021-05-18
BR112012023660B8 (pt) 2021-05-25
CN103025159A (zh) 2013-04-03
AU2011227023B2 (en) 2015-05-28
SI2547205T1 (sl) 2024-08-30
BR112012023660A2 (pt) 2015-09-15
EP2547205B1 (en) 2024-03-20
RS65536B1 (sr) 2024-06-28
DK2547205T3 (da) 2024-05-27
AU2011227023A1 (en) 2012-09-27
WO2011116399A1 (en) 2011-09-22
EP2547205A4 (en) 2013-08-14
US20130028944A1 (en) 2013-01-31
PL2547205T3 (pl) 2024-07-08
SMT202400193T1 (it) 2024-07-09

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20161028

FZDE Discontinued

Effective date: 20220201