CA2943733C - Polymer-based hydrotropes for hydrophobic drug delivery - Google Patents
Polymer-based hydrotropes for hydrophobic drug delivery Download PDFInfo
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- CA2943733C CA2943733C CA2943733A CA2943733A CA2943733C CA 2943733 C CA2943733 C CA 2943733C CA 2943733 A CA2943733 A CA 2943733A CA 2943733 A CA2943733 A CA 2943733A CA 2943733 C CA2943733 C CA 2943733C
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- polymer
- polymer conjugate
- hydrophobic
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- drug
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- 230000002209 hydrophobic effect Effects 0.000 title claims abstract description 53
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- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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Landscapes
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Applications Claiming Priority (3)
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| US201461976354P | 2014-04-07 | 2014-04-07 | |
| US61/976,354 | 2014-04-07 | ||
| PCT/JP2014/004480 WO2015155810A1 (en) | 2014-04-07 | 2014-09-01 | Novel polymer-based hydrotropes for hydrophobic drug delivery |
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| CA2943733A1 CA2943733A1 (en) | 2015-10-15 |
| CA2943733C true CA2943733C (en) | 2022-03-01 |
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| CN112402617B (zh) * | 2020-11-20 | 2023-06-09 | 汕头大学 | 血影紫杉醇及其制备方法与应用 |
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| US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
| US5811119A (en) | 1987-05-19 | 1998-09-22 | Board Of Regents, The University Of Texas | Formulation and use of carotenoids in treatment of cancer |
| ATE154514T1 (de) | 1989-09-29 | 1997-07-15 | Jolla Cancer Res Found | Inhibierung des transformierenden wachstumsfaktor zur verhinderung der anhäufung extrazellulärer matrix |
| US20040028682A1 (en) | 1989-09-29 | 2004-02-12 | Border Wayne A. | Inhibiting transforming growth factor beta to prevent accumulation of extracellular matrix |
| US5234604A (en) | 1991-02-26 | 1993-08-10 | Betz Laboratories, Inc. | Water soluble block copolymers and methods of use therof |
| AU670777B2 (en) | 1992-04-16 | 1996-08-01 | Ortho Pharmaceutical Corporation | Aqueous gel vehicles for retinoids |
| JPH08268906A (ja) | 1995-03-31 | 1996-10-15 | Sumitomo Pharmaceut Co Ltd | 肺線維症予防剤 |
| US6120794A (en) | 1995-09-26 | 2000-09-19 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
| US5851538A (en) | 1995-12-29 | 1998-12-22 | Advanced Polymer Systems, Inc. | Retinoid formulations in porous microspheres for reduced irritation and enhanced stability |
| US6183774B1 (en) | 1996-01-31 | 2001-02-06 | Collaborative Laboratories, Inc. | Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts |
| AU756301B2 (en) | 1997-08-20 | 2003-01-09 | Somagenics, Inc. | Antisense and antigene therapeutics with improved binding properties and methods for their use |
| JPH11269076A (ja) | 1998-01-22 | 1999-10-05 | Seikagaku Kogyo Co Ltd | 抗線維化剤 |
| DE60045890D1 (de) | 1999-04-27 | 2011-06-09 | Mitsubishi Tanabe Pharma Corp | Arzneimittel zur präventiven oder therapeutische Behandlung von Lebererkrankungen |
| US20020041898A1 (en) | 2000-01-05 | 2002-04-11 | Unger Evan C. | Novel targeted delivery systems for bioactive agents |
| EP1267834A4 (en) | 2000-03-29 | 2003-08-27 | Aradigm Corp | CATIONIC LIPOSOMES |
| JP2002047211A (ja) | 2000-08-04 | 2002-02-12 | Japan Science & Technology Corp | 脂溶性物質と生理活性高分子物質結合体および細胞核内への導入方法 |
| EP1392366A4 (en) | 2001-04-13 | 2005-01-19 | Population Council Inc | CORE RECEPTOR-MEDIATED INTRODUCTION OF A PNA PROTEIN IN CELL CHERRIES |
| JP4547696B2 (ja) | 2001-06-07 | 2010-09-22 | 第一三共株式会社 | 肝硬変予防・治療剤 |
| JP2002371006A (ja) | 2001-06-11 | 2002-12-26 | Mochida Pharmaceut Co Ltd | 肺線維症予防および／または進行防止剤 |
| JP2003119138A (ja) | 2001-10-09 | 2003-04-23 | Tohoku Techno Arch Co Ltd | 間質性肺炎および／または肺線維症の予防治療剤 |
| ES2284959T3 (es) | 2001-10-30 | 2007-11-16 | Nektar Therapeutics Al, Corporation | Conjugados polimericos solubles en agua de acido retinoico. |
| KR100990055B1 (ko) | 2001-11-21 | 2010-10-26 | 사이고 가오루 | 유전자 발현 억제 방법 |
| JP3803318B2 (ja) | 2001-11-21 | 2006-08-02 | 株式会社ＲＮＡｉ | 遺伝子発現阻害方法 |
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| DE602006013893D1 (de) * | 2005-12-05 | 2010-06-02 | Nitto Denko Corp | Polyglutamat-Aminosäure-Konjugate und Verfahren |
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- 2014-09-01 AU AU2014390729A patent/AU2014390729B2/en not_active Ceased
- 2014-09-01 CA CA2943733A patent/CA2943733C/en active Active
- 2014-09-01 WO PCT/JP2014/004480 patent/WO2015155810A1/en not_active Ceased
- 2014-09-01 JP JP2016561865A patent/JP6480467B2/ja not_active Expired - Fee Related
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- 2014-09-01 EP EP14762103.1A patent/EP3129425B1/en not_active Not-in-force
- 2014-09-01 KR KR1020167030960A patent/KR102256453B1/ko not_active Expired - Fee Related
- 2014-09-04 TW TW103130601A patent/TWI694838B/zh not_active IP Right Cessation
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2015
- 2015-04-06 US US14/679,404 patent/US10080737B2/en active Active
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| JP6480467B2 (ja) | 2019-03-13 |
| AU2014390729A1 (en) | 2016-11-17 |
| CN106133024B (zh) | 2019-07-05 |
| US20150283253A1 (en) | 2015-10-08 |
| EP3129425A1 (en) | 2017-02-15 |
| RU2676680C2 (ru) | 2019-01-10 |
| RU2016143395A3 (OSRAM) | 2018-05-07 |
| CA2943733A1 (en) | 2015-10-15 |
| AU2014390729B2 (en) | 2018-11-29 |
| JP2017516883A (ja) | 2017-06-22 |
| TW201540312A (zh) | 2015-11-01 |
| EP3129425B1 (en) | 2019-04-10 |
| US10080737B2 (en) | 2018-09-25 |
| RU2016143395A (ru) | 2018-05-07 |
| TWI694838B (zh) | 2020-06-01 |
| KR20170016822A (ko) | 2017-02-14 |
| KR102256453B1 (ko) | 2021-05-25 |
| CN106133024A (zh) | 2016-11-16 |
| WO2015155810A1 (en) | 2015-10-15 |
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