CA2942281C - Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof - Google Patents

Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof Download PDF

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Publication number
CA2942281C
CA2942281C CA2942281A CA2942281A CA2942281C CA 2942281 C CA2942281 C CA 2942281C CA 2942281 A CA2942281 A CA 2942281A CA 2942281 A CA2942281 A CA 2942281A CA 2942281 C CA2942281 C CA 2942281C
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Prior art keywords
antibody
binding fragment
analyte
singlet
binding
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CA2942281A
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English (en)
French (fr)
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CA2942281A1 (en
Inventor
Jay J. Li
David J. Ledden
Eric Scott COWDEN
Donglai LU
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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Publication of CA2942281A1 publication Critical patent/CA2942281A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2942281A 2014-03-26 2015-03-24 Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof Active CA2942281C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461970596P 2014-03-26 2014-03-26
US61/970,596 2014-03-26
PCT/US2015/022209 WO2015148479A1 (en) 2014-03-26 2015-03-24 Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof

Publications (2)

Publication Number Publication Date
CA2942281A1 CA2942281A1 (en) 2015-10-01
CA2942281C true CA2942281C (en) 2023-03-14

Family

ID=54196294

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2942281A Active CA2942281C (en) 2014-03-26 2015-03-24 Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof

Country Status (11)

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US (2) US20170176419A1 (enExample)
EP (2) EP3483593B1 (enExample)
JP (1) JP6596440B2 (enExample)
CN (1) CN106662532B (enExample)
AU (1) AU2015236288A1 (enExample)
CA (1) CA2942281C (enExample)
DK (2) DK3483593T3 (enExample)
ES (2) ES2884930T3 (enExample)
IL (1) IL247630A0 (enExample)
MX (1) MX377772B (enExample)
WO (1) WO2015148479A1 (enExample)

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US10928388B2 (en) 2016-12-09 2021-02-23 Abbott Point Of Care Inc. Combined immunoassay and magnetic immunoassay methods for extended range of sensitivity
US10871488B2 (en) 2016-12-09 2020-12-22 Abbott Point Of Care Inc. Crossover analytical systems and methods using an immunosensor and magnetic immunosensor
CN110192109B (zh) 2016-12-09 2023-07-28 雅培医护站股份有限公司 用于扩展范围的灵敏度的联合免疫测定和磁免疫测定系统和装置
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CN111770935A (zh) * 2018-02-27 2020-10-13 株式会社岛津制作所 特异性识别APP669-x的N末端的抗体及免疫测定法
WO2019167128A1 (ja) * 2018-02-27 2019-09-06 株式会社 島津製作所 サンドイッチ型免疫測定法
EP3830556B1 (en) 2018-07-30 2024-11-13 Siemens Healthcare Diagnostics Inc. Kits, microfluidics devices, and methods for performing biotin assays
ES2942134T3 (es) * 2018-09-25 2023-05-30 Siemens Healthcare Diagnostics Inc Composiciones, kits y métodos para ensayos multiplex para corregir la interferencia de biotina en mediciones de analitos diana
WO2021041607A1 (en) * 2019-08-29 2021-03-04 Siemens Healthcare Diagnostics Inc. Device and method to evaluate a fluid sample on a single-use multianalyte consumable
CN113125416B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光检测方法及其应用
CN113125731B (zh) * 2019-12-31 2025-09-16 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光测定试剂盒及其应用
CN113125418A (zh) * 2019-12-31 2021-07-16 科美诊断技术股份有限公司 一种均相化学发光检测方法及其应用
CN113125415B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光检测方法及其应用
CN113125706B (zh) * 2019-12-31 2025-07-08 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光测定试剂盒及其应用
CN113125704B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种均相化学发光测定试剂盒及其应用
WO2021217178A1 (en) * 2020-04-24 2021-10-28 Siemens Healthcare Diagnostics Inc. Calibration and quality control reagents for use with immunoassays for antibodies
CN111781385B (zh) * 2020-08-19 2023-07-18 武汉生之源生物科技股份有限公司 一种NT-proBNP检测试剂盒及其制备方法
CN114544978A (zh) * 2022-03-04 2022-05-27 美康生物科技股份有限公司 一种igf-1检测试剂盒及其制备方法和检测方法

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Also Published As

Publication number Publication date
CN106662532B (zh) 2019-12-13
EP3123151B1 (en) 2018-11-28
EP3123151A1 (en) 2017-02-01
EP3123151A4 (en) 2017-03-22
US20170176419A1 (en) 2017-06-22
US12366571B2 (en) 2025-07-22
EP3483593A1 (en) 2019-05-15
CA2942281A1 (en) 2015-10-01
ES2884930T3 (es) 2021-12-13
CN106662532A (zh) 2017-05-10
MX377772B (es) 2025-03-11
US20210231647A1 (en) 2021-07-29
ES2713428T3 (es) 2019-05-21
JP6596440B2 (ja) 2019-10-23
MX2016011809A (es) 2017-05-10
IL247630A0 (en) 2016-11-30
DK3483593T3 (da) 2021-07-19
WO2015148479A1 (en) 2015-10-01
DK3123151T3 (en) 2019-03-18
JP2017508971A (ja) 2017-03-30
EP3483593B1 (en) 2021-04-28
AU2015236288A1 (en) 2016-09-15

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