AU2015236288A1 - Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof - Google Patents

Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof Download PDF

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Publication number
AU2015236288A1
AU2015236288A1 AU2015236288A AU2015236288A AU2015236288A1 AU 2015236288 A1 AU2015236288 A1 AU 2015236288A1 AU 2015236288 A AU2015236288 A AU 2015236288A AU 2015236288 A AU2015236288 A AU 2015236288A AU 2015236288 A1 AU2015236288 A1 AU 2015236288A1
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AU
Australia
Prior art keywords
antibody
binding fragment
analyte
binding
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2015236288A
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English (en)
Inventor
Eric Scott COWDEN
David J. Ledden
Jay J. Li
Donglai LU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Publication of AU2015236288A1 publication Critical patent/AU2015236288A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AU2015236288A 2014-03-26 2015-03-24 Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof Abandoned AU2015236288A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461970596P 2014-03-26 2014-03-26
US61/970,596 2014-03-26
PCT/US2015/022209 WO2015148479A1 (en) 2014-03-26 2015-03-24 Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof

Publications (1)

Publication Number Publication Date
AU2015236288A1 true AU2015236288A1 (en) 2016-09-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015236288A Abandoned AU2015236288A1 (en) 2014-03-26 2015-03-24 Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof

Country Status (11)

Country Link
US (2) US20170176419A1 (enExample)
EP (2) EP3483593B1 (enExample)
JP (1) JP6596440B2 (enExample)
CN (1) CN106662532B (enExample)
AU (1) AU2015236288A1 (enExample)
CA (1) CA2942281C (enExample)
DK (2) DK3483593T3 (enExample)
ES (2) ES2884930T3 (enExample)
IL (1) IL247630A0 (enExample)
MX (1) MX377772B (enExample)
WO (1) WO2015148479A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018107013A1 (en) * 2016-12-09 2018-06-14 Abbott Point Of Care Inc. Dual range cardiac troponin immunoassay devices and methods using immunosensor and magnetic immunosensor
WO2018107016A1 (en) 2016-12-09 2018-06-14 Abbott Point Of Care Inc. Ameliorated crosstalk immunoassay test device for determining a concentration of an analyte
US10928388B2 (en) 2016-12-09 2021-02-23 Abbott Point Of Care Inc. Combined immunoassay and magnetic immunoassay methods for extended range of sensitivity
US10871488B2 (en) 2016-12-09 2020-12-22 Abbott Point Of Care Inc. Crossover analytical systems and methods using an immunosensor and magnetic immunosensor
CN110192109B (zh) 2016-12-09 2023-07-28 雅培医护站股份有限公司 用于扩展范围的灵敏度的联合免疫测定和磁免疫测定系统和装置
EP3552016A1 (en) 2016-12-09 2019-10-16 Abbott Point of Care Inc. Extended range immunoassay devices with immunosensor and magnetic immunosensor
CN111770935A (zh) * 2018-02-27 2020-10-13 株式会社岛津制作所 特异性识别APP669-x的N末端的抗体及免疫测定法
WO2019167128A1 (ja) * 2018-02-27 2019-09-06 株式会社 島津製作所 サンドイッチ型免疫測定法
EP3830556B1 (en) 2018-07-30 2024-11-13 Siemens Healthcare Diagnostics Inc. Kits, microfluidics devices, and methods for performing biotin assays
ES2942134T3 (es) * 2018-09-25 2023-05-30 Siemens Healthcare Diagnostics Inc Composiciones, kits y métodos para ensayos multiplex para corregir la interferencia de biotina en mediciones de analitos diana
WO2021041607A1 (en) * 2019-08-29 2021-03-04 Siemens Healthcare Diagnostics Inc. Device and method to evaluate a fluid sample on a single-use multianalyte consumable
CN113125416B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光检测方法及其应用
CN113125731B (zh) * 2019-12-31 2025-09-16 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光测定试剂盒及其应用
CN113125418A (zh) * 2019-12-31 2021-07-16 科美诊断技术股份有限公司 一种均相化学发光检测方法及其应用
CN113125415B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光检测方法及其应用
CN113125706B (zh) * 2019-12-31 2025-07-08 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光测定试剂盒及其应用
CN113125704B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种均相化学发光测定试剂盒及其应用
WO2021217178A1 (en) * 2020-04-24 2021-10-28 Siemens Healthcare Diagnostics Inc. Calibration and quality control reagents for use with immunoassays for antibodies
CN111781385B (zh) * 2020-08-19 2023-07-18 武汉生之源生物科技股份有限公司 一种NT-proBNP检测试剂盒及其制备方法
CN114544978A (zh) * 2022-03-04 2022-05-27 美康生物科技股份有限公司 一种igf-1检测试剂盒及其制备方法和检测方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
NO164622C (no) * 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
EP0542810A1 (en) 1990-08-02 1993-05-26 B.R. Centre Limited Methods for the production of proteins with a desired function
DE69232161T2 (de) * 1991-05-22 2002-05-16 Dade Behring Marburg Gmbh Bestimmungsmethoden unter Verwendung von induzierter Lumineszenz
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
GB9326238D0 (en) * 1993-12-23 1994-02-23 Sinvent As Method of assay
US7285418B2 (en) * 1996-06-25 2007-10-23 Hytest Ltd. Method and kit for the diagnosis of troponin I
US6248546B1 (en) * 1998-03-09 2001-06-19 Diagnostic Systems Laboratories, Inc. Assay of IGFBP complex
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
DE10064827A1 (de) * 2000-12-22 2002-06-27 Dade Behring Marburg Gmbh Nachweisverfahren
US6551788B1 (en) * 2001-11-28 2003-04-22 Beckman Coulter, Inc. Particle-based ligand assay with extended dynamic range
US6764819B2 (en) * 2002-07-16 2004-07-20 Emp Biotech Gmbh Method for chemiluminescent detection
US20050170443A1 (en) * 2003-10-03 2005-08-04 Scantibodies Laboratory, Inc. Methods and use of binding components for improving assay specificity
WO2007001378A2 (en) * 2004-09-20 2007-01-04 Boston Microfluidics Microfluidic device for detecting soluble molecules
US20060263907A1 (en) * 2005-04-29 2006-11-23 Zweig Stephen E Fluorescence lateral flow immunoassay
US8124015B2 (en) * 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
GB2436616A (en) * 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
NZ575827A (en) * 2006-09-21 2012-02-24 Prometheus Lab Inc Antibody-based arrays for detecting multiple signal transducers in rare circulating cells
EP2132229B1 (en) * 2007-03-01 2016-05-11 Symphogen A/S Recombinant anti-epidermal growth factor receptor antibody compositions
US7790401B2 (en) * 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
US20090170218A1 (en) * 2008-01-02 2009-07-02 Dade Behring Inc. Methods for detection of cyclosporin a
US20120288961A1 (en) * 2009-12-22 2012-11-15 University Of Washington Capillarity-based devices for performing chemical processes and associated systems and methods
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US10088490B2 (en) * 2010-08-20 2018-10-02 Siemens Healthcare Diagnostics Inc. Assay for analytes using multiple receptors
CN102565381B (zh) * 2010-12-08 2014-06-18 中国科学院生态环境研究中心 导电微粒子介导电化学发光信号的免疫检测方法
DK2760998T3 (en) 2011-11-22 2017-04-24 Siemens Healthcare Diagnostics Inc Devices with dried reagents for reconstitution as calibration and / or quality control solutions, and methods of preparation and use thereof
EP3418743B1 (en) * 2013-03-15 2020-04-29 Siemens Healthcare Diagnostics Inc. Luminescent oxygen channeling immunoassays utilizing electrochemical discharge of singlet oxygen and methods of production and use thereof
CN105026932B (zh) 2013-03-15 2017-06-13 西门子医疗保健诊断公司 微流控分配设备
WO2014151590A1 (en) 2013-03-15 2014-09-25 Siemens Healthcare Diagnostics Inc. Heterogeneous luminescent oxygen channeling immunoassays and methods of production and use thereof
US10371643B2 (en) 2013-03-15 2019-08-06 Siemens Healthcare Diagnostics Inc. Luminescent oxygen channeling immunoassays
EP4067383A1 (en) * 2013-07-25 2022-10-05 Cytomx Therapeutics Inc. Multispecific antibodies, multispecific activatable antibodies and methods of using the same
US20160320415A1 (en) * 2013-12-16 2016-11-03 Xen Biofluidx, Inc. Fast reconstituting reagent pellets

Also Published As

Publication number Publication date
CN106662532B (zh) 2019-12-13
EP3123151B1 (en) 2018-11-28
EP3123151A1 (en) 2017-02-01
EP3123151A4 (en) 2017-03-22
US20170176419A1 (en) 2017-06-22
US12366571B2 (en) 2025-07-22
EP3483593A1 (en) 2019-05-15
CA2942281A1 (en) 2015-10-01
ES2884930T3 (es) 2021-12-13
CN106662532A (zh) 2017-05-10
MX377772B (es) 2025-03-11
US20210231647A1 (en) 2021-07-29
CA2942281C (en) 2023-03-14
ES2713428T3 (es) 2019-05-21
JP6596440B2 (ja) 2019-10-23
MX2016011809A (es) 2017-05-10
IL247630A0 (en) 2016-11-30
DK3483593T3 (da) 2021-07-19
WO2015148479A1 (en) 2015-10-01
DK3123151T3 (en) 2019-03-18
JP2017508971A (ja) 2017-03-30
EP3483593B1 (en) 2021-04-28

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MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period