CA2936116A1 - Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators - Google Patents

Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators Download PDF

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Publication number
CA2936116A1
CA2936116A1 CA2936116A CA2936116A CA2936116A1 CA 2936116 A1 CA2936116 A1 CA 2936116A1 CA 2936116 A CA2936116 A CA 2936116A CA 2936116 A CA2936116 A CA 2936116A CA 2936116 A1 CA2936116 A1 CA 2936116A1
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Prior art keywords
cr2e
substituted
alkyl
hydrogen
independently
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Abandoned
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CA2936116A
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English (en)
French (fr)
Inventor
Jingwu Duan
T.G. Murali Dhar
Bin Jiang
Zhonghui Lu
Hai-Yun Xiao
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CA2936116A1 publication Critical patent/CA2936116A1/en
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
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  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2936116A 2014-01-06 2015-01-05 Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators Abandoned CA2936116A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461923896P 2014-01-06 2014-01-06
US61/923,896 2014-01-06
PCT/US2015/010089 WO2015103509A1 (en) 2014-01-06 2015-01-05 Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators

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CA2936116A1 true CA2936116A1 (en) 2015-07-09

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US (2) US20160326108A1 (enExample)
EP (1) EP3092229B1 (enExample)
JP (1) JP6530764B2 (enExample)
CN (1) CN106061971B (enExample)
AR (1) AR099029A1 (enExample)
CA (1) CA2936116A1 (enExample)
EA (1) EA030849B1 (enExample)
ES (1) ES2669208T3 (enExample)
MX (1) MX369347B (enExample)
TW (1) TW201609634A (enExample)
WO (1) WO2015103509A1 (enExample)

Families Citing this family (21)

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WO2015035278A1 (en) 2013-09-09 2015-03-12 Bristol-Myers Squibb Company RORγ MODULATORS
WO2015042212A1 (en) 2013-09-20 2015-03-26 Bristol-Myers Squibb Company RORγ MODULATORS
EP3092215B1 (en) 2014-01-06 2018-10-17 Bristol-Myers Squibb Company Cyclohexyl sulfone ror gamma modulators
WO2015103508A1 (en) 2014-01-06 2015-07-09 Bristol-Myers Squibb Company CARBOCYCLIC SULFONE RORγ MODULATORS
JP6476205B2 (ja) 2014-01-06 2019-02-27 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ修飾因子としてのヘテロ環式スルホン
US9861618B2 (en) 2014-10-30 2018-01-09 Janssen Pharmaceutica Nv Thiazoles as modulators of RORγt
TWI705057B (zh) 2014-10-30 2020-09-21 比利時商健生藥品公司 用作ＲＯＲγｔ調節劑之三氟甲基醇
WO2016069978A1 (en) 2014-10-30 2016-05-06 Janssen Pharmaceutica Nv AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORγT
CN107709295B (zh) 2015-05-07 2021-05-04 百时美施贵宝公司 作为RORγ调节剂的三环砜类
WO2017170830A1 (ja) * 2016-03-31 2017-10-05 武田薬品工業株式会社 複素環化合物
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