EA030849B1 - ПИРРОЛИДИНИЛСУЛЬФОНОВЫЕ МОДУЛЯТОРЫ RORγ - Google Patents

ПИРРОЛИДИНИЛСУЛЬФОНОВЫЕ МОДУЛЯТОРЫ RORγ Download PDF

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EA030849B1
EA030849B1 EA201691368A EA201691368A EA030849B1 EA 030849 B1 EA030849 B1 EA 030849B1 EA 201691368 A EA201691368 A EA 201691368A EA 201691368 A EA201691368 A EA 201691368A EA 030849 B1 EA030849 B1 EA 030849B1
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substituted
mmol
phenyl
alkyl
mixture
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EA201691368A
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Russian (ru)
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EA201691368A1 (ru
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Цзиньву Дуань
Т.Г. Мурали Дхар
Бинь Цзян
Чжунхуэй Люй
Хай-Юнь Сяо
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Бристол-Маерс Сквибб Компани
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Publication of EA201691368A1 publication Critical patent/EA201691368A1/ru
Publication of EA030849B1 publication Critical patent/EA030849B1/ru

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201691368A 2014-01-06 2015-01-05 ПИРРОЛИДИНИЛСУЛЬФОНОВЫЕ МОДУЛЯТОРЫ RORγ EA030849B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461923896P 2014-01-06 2014-01-06
PCT/US2015/010089 WO2015103509A1 (en) 2014-01-06 2015-01-05 Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators

Publications (2)

Publication Number Publication Date
EA201691368A1 EA201691368A1 (ru) 2016-10-31
EA030849B1 true EA030849B1 (ru) 2018-10-31

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EA201691368A EA030849B1 (ru) 2014-01-06 2015-01-05 ПИРРОЛИДИНИЛСУЛЬФОНОВЫЕ МОДУЛЯТОРЫ RORγ

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US (2) US20160326108A1 (enExample)
EP (1) EP3092229B1 (enExample)
JP (1) JP6530764B2 (enExample)
CN (1) CN106061971B (enExample)
AR (1) AR099029A1 (enExample)
CA (1) CA2936116A1 (enExample)
EA (1) EA030849B1 (enExample)
ES (1) ES2669208T3 (enExample)
MX (1) MX369347B (enExample)
TW (1) TW201609634A (enExample)
WO (1) WO2015103509A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3044219A1 (en) 2013-09-09 2016-07-20 Bristol-Myers Squibb Company Rorgamma modulators
EP3046906B1 (en) 2013-09-20 2017-08-16 Bristol-Myers Squibb Company Ror gamma modulators
EP3092216B1 (en) 2014-01-06 2018-12-12 Bristol-Myers Squibb Company Carbocyclic sulfone ror gamma modulators
US9708253B2 (en) 2014-01-06 2017-07-18 Bristol-Myers Squibb Company Cyclohexyl sulfone RORγ modulators
CN106061956B (zh) 2014-01-06 2021-03-12 百时美施贵宝公司 作为RORγ调节剂的杂环砜
RS58250B1 (sr) 2014-10-30 2019-03-29 Janssen Pharmaceutica Nv Tiazoli kao modulatori roryt
JOP20200117A1 (ar) 2014-10-30 2017-06-16 Janssen Pharmaceutica Nv كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t
SMT201900706T1 (it) 2014-10-30 2020-01-14 Janssen Pharmaceutica Nv Tiazoli sostituiti con ammide come modulatori di rorgammat
ES2887087T3 (es) 2015-05-07 2021-12-21 Bristol Myers Squibb Co Sulfonas tricíclicas como moduladores ROR gamma
WO2017170830A1 (ja) * 2016-03-31 2017-10-05 武田薬品工業株式会社 複素環化合物
TW201803869A (zh) 2016-04-27 2018-02-01 健生藥品公司 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑
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CN106061971A (zh) 2016-10-26
JP6530764B2 (ja) 2019-06-12
TW201609634A (zh) 2016-03-16
EA201691368A1 (ru) 2016-10-31
US20160326108A1 (en) 2016-11-10
CN106061971B (zh) 2019-03-12
US20150191483A1 (en) 2015-07-09
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