CA2935899C - Fluorinated cbd compounds, compositions and uses thereof - Google Patents
Fluorinated cbd compounds, compositions and uses thereof Download PDFInfo
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- CA2935899C CA2935899C CA2935899A CA2935899A CA2935899C CA 2935899 C CA2935899 C CA 2935899C CA 2935899 A CA2935899 A CA 2935899A CA 2935899 A CA2935899 A CA 2935899A CA 2935899 C CA2935899 C CA 2935899C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
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- A61P27/12—Ophthalmic agents for cataracts
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/373—Halogenated derivatives with all hydroxy groups on non-condensed rings and with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/16—Acetic acid esters of dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750043P | 2013-01-08 | 2013-01-08 | |
| US61/750,043 | 2013-01-08 | ||
| PCT/IL2014/050023 WO2014108899A1 (en) | 2013-01-08 | 2014-01-08 | Fluorinated cbd compounds, compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2935899A1 CA2935899A1 (en) | 2014-07-17 |
| CA2935899C true CA2935899C (en) | 2021-08-31 |
Family
ID=50272668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2935899A Active CA2935899C (en) | 2013-01-08 | 2014-01-08 | Fluorinated cbd compounds, compositions and uses thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9447019B2 (enExample) |
| EP (1) | EP2943463B1 (enExample) |
| JP (3) | JP6228230B2 (enExample) |
| CN (1) | CN105209424B (enExample) |
| AU (2) | AU2014206036B2 (enExample) |
| CA (1) | CA2935899C (enExample) |
| ES (1) | ES2894836T3 (enExample) |
| MX (1) | MX381719B (enExample) |
| WO (1) | WO2014108899A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX381719B (es) | 2013-01-08 | 2025-03-12 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Compuestos cbd fluorados, composiciones y usos de los mismos. |
| GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| JP2018529636A (ja) * | 2015-07-16 | 2018-10-11 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム リミテッドＹｉｓｓｕｍ Ｒｅｓｅａｒｃｈ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ Ｏｆ Ｔｈｅ Ｈｅｂｒｅｗ Ｕｎｉｖｅｒｓｔｙ Ｏｆ Ｊｅｒｕｓａｌｅｍ Ｌｔｄ． | フッ素化ｃｂｄ化合物、組成物、及びその使用 |
| US11207414B2 (en) | 2015-09-22 | 2021-12-28 | Graphium Biosciences, Inc. | Cannabinoid glycoside prodrugs and methods of synthesis |
| WO2021173130A1 (en) | 2020-02-26 | 2021-09-02 | Vitality Biopharma, Inc. | Novel cannabinoid glycosides and uses thereof |
| WO2017066744A1 (en) * | 2015-10-16 | 2017-04-20 | Scythian Biosciences Inc. | Methods and compositions for treating traumatic brain injury |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| US11207291B2 (en) | 2017-05-09 | 2021-12-28 | Graphium Biosciences, Inc. | Antimicrobial compositions comprising cannabinoids and methods of using the same |
| AU2018275687A1 (en) | 2017-05-31 | 2020-01-02 | Phytecs, Inc. | Pharmaceutical compositions comprising cannabidiol and beta-caryophyllene and methods for their use |
| EP3967301B1 (en) | 2017-09-28 | 2024-06-19 | Zynerba Pharmaceuticals, Inc. | Treatment of irritability in autism spectrum disorder with cannabidiol |
| GB2568929A (en) | 2017-12-01 | 2019-06-05 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| JOP20210140A1 (ar) | 2018-12-14 | 2023-01-30 | Zynerba Pharmaceuticals Inc | معالجة متلازمة الحذف 22q11.2 بكانابيديول |
| EP4069215A4 (en) | 2019-12-06 | 2024-01-17 | Jlabs Beauty LLC | TOPICAL COMPOSITIONS CONTAINING ROSE OIL AND CANNABIDIOL AND METHODS OF PREPARING AND USING THE SAME |
| GB202002754D0 (en) | 2020-02-27 | 2020-04-15 | Gw Res Ltd | Methods of treating tuberous sclerosis complex with cannabidiol and everolimus |
| AU2021276680A1 (en) | 2020-05-22 | 2023-01-19 | Ilera Derm LLC | Compositions for treating acne and dermatological conditions |
| GB2642523A (en) * | 2024-07-12 | 2026-01-14 | Sonas Pharmaceuticals N I Ltd | Novel halogenated cannabinoid derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
| DK2176208T3 (en) * | 2007-07-30 | 2015-04-27 | Zynerba Pharmaceuticals Inc | Prodrugs of cannabidiol, compositions containing prodrugs of cannabidiol and methods of use thereof |
| US20120172339A1 (en) | 2009-07-10 | 2012-07-05 | Northeastern University | Angiogenic resorcinol derivatives |
| LT2473475T (lt) * | 2009-08-31 | 2017-08-10 | Zynerba Pharmaceuticals, Inc. | Kanabidiolio provaisto panaudojimas vietiniam arba transderminiam įvedimui su mikroadatomis |
| WO2012011112A1 (en) * | 2010-07-22 | 2012-01-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Non psychoactive cannabinoids and uses thereof |
| MX381719B (es) * | 2013-01-08 | 2025-03-12 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Compuestos cbd fluorados, composiciones y usos de los mismos. |
-
2014
- 2014-01-08 MX MX2015008766A patent/MX381719B/es unknown
- 2014-01-08 WO PCT/IL2014/050023 patent/WO2014108899A1/en not_active Ceased
- 2014-01-08 CN CN201480012168.2A patent/CN105209424B/zh active Active
- 2014-01-08 JP JP2015551255A patent/JP6228230B2/ja active Active
- 2014-01-08 CA CA2935899A patent/CA2935899C/en active Active
- 2014-01-08 ES ES14709750T patent/ES2894836T3/es active Active
- 2014-01-08 US US14/759,689 patent/US9447019B2/en active Active
- 2014-01-08 AU AU2014206036A patent/AU2014206036B2/en active Active
- 2014-01-08 EP EP14709750.5A patent/EP2943463B1/en active Active
-
2016
- 2016-08-19 US US15/241,557 patent/US9782360B2/en active Active
-
2017
- 2017-08-01 US US15/666,128 patent/US10441553B2/en active Active
- 2017-10-12 JP JP2017198146A patent/JP2018065794A/ja active Pending
-
2018
- 2018-01-24 AU AU2018200570A patent/AU2018200570B2/en active Active
-
2019
- 2019-01-28 JP JP2019012349A patent/JP6952727B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6228230B2 (ja) | 2017-11-08 |
| US9782360B2 (en) | 2017-10-10 |
| MX381719B (es) | 2025-03-12 |
| CN105209424A (zh) | 2015-12-30 |
| CA2935899A1 (en) | 2014-07-17 |
| US9447019B2 (en) | 2016-09-20 |
| MX2015008766A (es) | 2016-03-07 |
| AU2014206036A1 (en) | 2015-08-13 |
| AU2014206036B2 (en) | 2017-11-02 |
| WO2014108899A1 (en) | 2014-07-17 |
| EP2943463A1 (en) | 2015-11-18 |
| AU2018200570A1 (en) | 2018-02-15 |
| ES2894836T3 (es) | 2022-02-16 |
| JP6952727B2 (ja) | 2021-10-20 |
| JP2016505614A (ja) | 2016-02-25 |
| JP2018065794A (ja) | 2018-04-26 |
| EP2943463B1 (en) | 2021-07-14 |
| JP2019073547A (ja) | 2019-05-16 |
| CN105209424B (zh) | 2019-12-13 |
| AU2018200570B2 (en) | 2019-09-26 |
| US10441553B2 (en) | 2019-10-15 |
| HK1214586A1 (zh) | 2016-07-29 |
| AU2014206036A2 (en) | 2016-06-16 |
| US20170326078A1 (en) | 2017-11-16 |
| US20150344403A1 (en) | 2015-12-03 |
| US20170197904A1 (en) | 2017-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190107 |