CA2934538C - Drug mixing and delivery system and method - Google Patents

Drug mixing and delivery system and method Download PDF

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Publication number
CA2934538C
CA2934538C CA2934538A CA2934538A CA2934538C CA 2934538 C CA2934538 C CA 2934538C CA 2934538 A CA2934538 A CA 2934538A CA 2934538 A CA2934538 A CA 2934538A CA 2934538 C CA2934538 C CA 2934538C
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CA
Canada
Prior art keywords
acid
liquid
epinephrine
dry
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2934538A
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English (en)
French (fr)
Other versions
CA2934538A1 (en
Inventor
Brent A. Buchine
Adam R. Standley
Christopher J. Stepanian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Windgap Medical Inc
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Windgap Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Windgap Medical Inc filed Critical Windgap Medical Inc
Publication of CA2934538A1 publication Critical patent/CA2934538A1/en
Application granted granted Critical
Publication of CA2934538C publication Critical patent/CA2934538C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3294—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/364—General characteristics of the apparatus related to heating or cooling by chemical reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/366—General characteristics of the apparatus related to heating or cooling by liquid heat exchangers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CA2934538A 2013-12-18 2014-12-18 Drug mixing and delivery system and method Active CA2934538C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361917925P 2013-12-18 2013-12-18
US61/917,925 2013-12-18
US201462016260P 2014-06-24 2014-06-24
US62/016,260 2014-06-24
PCT/US2014/071324 WO2015095624A2 (en) 2013-12-18 2014-12-18 Drug mixing and delivery system and method

Publications (2)

Publication Number Publication Date
CA2934538A1 CA2934538A1 (en) 2015-06-25
CA2934538C true CA2934538C (en) 2023-03-14

Family

ID=53403885

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2934538A Active CA2934538C (en) 2013-12-18 2014-12-18 Drug mixing and delivery system and method

Country Status (7)

Country Link
US (2) US20150231334A1 (enExample)
EP (1) EP3082419A4 (enExample)
JP (4) JP2017503017A (enExample)
CN (2) CN113230486A (enExample)
AU (3) AU2014364433A1 (enExample)
CA (1) CA2934538C (enExample)
WO (1) WO2015095624A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12239822B2 (en) 2013-03-15 2025-03-04 Windgap Medical, Inc. Portable drug mixing and delivery device and associated methods
JP2017503017A (ja) 2013-12-18 2017-01-26 ウィンドギャップ メディカル， インコーポレイテッド 薬物混合および送達システムならびに方法
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
AU2015364280A1 (en) * 2014-12-18 2017-07-06 Windgap Medical, Inc. Method and compositions for dissolving or solubilizing therapeutic agents
US10695495B2 (en) 2015-03-24 2020-06-30 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
EP3397320B1 (en) 2015-12-30 2024-11-27 Ascendis Pharma A/S Auto injector with charger safety
EP4527432A3 (en) 2015-12-30 2025-06-04 Ascendis Pharma A/S Auto injector with adaptable air-shot mechanism
JP6832369B2 (ja) 2015-12-30 2021-02-24 アセンディス ファーマ エー／エス カートリッジ保持システムを備える自動注射器
CA3290056A1 (en) 2015-12-30 2025-11-29 Ascendis Pharma A/S Auto injector with detection of plunger resistance
JP7051702B2 (ja) * 2015-12-30 2022-04-11 アセンディス ファーマ エー／エス 温度制御付き自動注射器
US10420955B2 (en) * 2016-01-18 2019-09-24 Nikolai Tankovich Attachable tip for laser hand piece
FR3047903B1 (fr) * 2016-02-18 2018-03-23 Crossject Dispositif d’injection sans aiguille a membrane cintree
CN115591054A (zh) 2017-05-23 2023-01-13 阿森迪斯药物股份有限公司（Dk） 自动注射器、系统和用于控制自动注射器的方法
SG11201910224VA (en) 2017-06-29 2020-01-30 Ascendis Pharma As Auto injector with reconstitution handling support
CN115990296B (zh) 2017-09-22 2025-04-01 贝克顿·迪金森公司 用作导管封管液的4%柠檬酸三钠溶液
WO2019136512A1 (en) 2018-01-10 2019-07-18 Eye Co Pty Ltd Medical device and pharmaceutical composition for treatment of an eye disease or condition
WO2019156239A1 (ja) * 2018-02-09 2019-08-15 株式会社ダイセル 注入器及びそれを用いた注入対象の細胞核内への生体分子を含む溶液の注入方法
WO2019182745A1 (en) 2018-03-19 2019-09-26 Bryn Pharma, LLC Epinephrine spray formulations
CA3205655A1 (en) 2020-12-23 2022-06-30 Tolmar International Limited Systems and methods for mixing syringe valve assemblies
US12414916B2 (en) 2021-06-10 2025-09-16 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
US11918778B2 (en) 2021-08-19 2024-03-05 Innovative Health Strategies Llc Smart self-activating wearable device for automatically injecting medicines
GB2616663A (en) * 2022-03-18 2023-09-20 Alkaloid Ad Skopje Pharmaceutical formulation
USD1029245S1 (en) 2022-06-22 2024-05-28 Tolmar International Limited Syringe connector
WO2024211916A2 (en) * 2023-04-06 2024-10-10 Windgap Medical, Inc. Automated and semi-automated mixing and automated delivery autoinjector
AU2024274661A1 (en) * 2023-05-25 2026-01-15 Meridian Medical Technologies, Llc Auto-injector system
US12502498B1 (en) 2024-10-21 2025-12-23 Belhaven BioPharma Inc. Compositions, devices, and methods for intranasal delivery of dry powder epinephrine

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1077842A (en) * 1975-10-09 1980-05-20 Minnesota Mining And Manufacturing Company Albumin medicament carrier system
JPS5375650A (en) 1976-12-17 1978-07-05 Hitachi Ltd Elevator cage
US4479794A (en) * 1981-11-27 1984-10-30 Alza Corporation System for intravenous therapy
US4511351A (en) * 1984-05-14 1985-04-16 Alza Corporation Parenteral delivery system utilizing a hollow fiber cellular unit
US4689042A (en) 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
ES2024489B3 (es) 1986-05-15 1992-03-01 Duphar Int Res B V Inyector automatico.
FR2741810B1 (fr) 1995-11-30 1998-02-20 Soc Et Et D Applic Tech Sedat Seringue pour l'injection d'un melange extemporane
US6428528B2 (en) 1998-08-11 2002-08-06 Antares Pharma, Inc. Needle assisted jet injector
WO2000048662A1 (en) * 1999-02-16 2000-08-24 Prismedical Corporation Single dose delivery device
DE60023677T2 (de) 1999-04-16 2006-08-24 Becton Dickinson And Co. Stiftförmiger injektor mit merkmalen zur automatischen substanzkombination
US6527738B1 (en) * 1999-04-30 2003-03-04 Prismedical Corporation Drug delivery pack
US6428505B1 (en) * 1999-11-19 2002-08-06 Prismedical Corporation In-line IV drug delivery pack with controllable dilution
US6641561B1 (en) 2000-10-10 2003-11-04 Meridian Medical Technologies, Inc. Drug delivery device
US7621887B2 (en) 2000-10-10 2009-11-24 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US7544189B2 (en) 2000-10-10 2009-06-09 Meridian Medical Technologies, Inc. Needle and hub assembly for automatic injector
US6656150B2 (en) 2000-10-10 2003-12-02 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US6770052B2 (en) 2000-10-10 2004-08-03 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US7556614B2 (en) 2000-10-10 2009-07-07 Meridian Medical Technologies, Inc. Separation assembly for drug delivery device
US20030105430A1 (en) 2001-11-30 2003-06-05 Elan Pharma International Limited Wil House Automatic injector
US6743194B2 (en) * 2002-03-28 2004-06-01 Igal Sharon Multi-compartment syringe
US7947742B2 (en) * 2002-06-28 2011-05-24 Civitas Therapeutics, Inc. Inhalable epinephrine
US6953455B2 (en) 2002-07-30 2005-10-11 Hospira, Inc. Medicine delivery system
US20040110781A1 (en) 2002-12-05 2004-06-10 Harmon Troy M. Pharmaceutical compositions containing indistinguishable drug components
WO2006078282A2 (en) * 2004-04-28 2006-07-27 Angiotech Biomaterials Corporation Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US7449012B2 (en) 2004-08-06 2008-11-11 Meridian Medical Technologies, Inc. Automatic injector
US8048035B2 (en) 2004-08-06 2011-11-01 Meridian Medical Technologies, Inc. Automatic injector with needle cover
CN1303987C (zh) 2004-11-19 2007-03-14 陈庆财 注射用盐酸艾司洛尔冻干粉针剂及其制备方法
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
WO2006058061A1 (en) 2004-11-24 2006-06-01 Becton Dickinson And Company Automatic reconstitution injector device
CA2594627C (en) 2005-02-01 2012-04-17 Intelliject, Llc Devices, systems, and methods for medicament delivery
WO2006122183A2 (en) 2005-05-10 2006-11-16 Cytophil, Inc. Injectable hydrogels and methods of making and using same
GB0523638D0 (en) * 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
US7323477B2 (en) * 2006-02-02 2008-01-29 Allergan, Inc. 7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline
TW200744568A (en) * 2006-02-28 2007-12-16 Verus Pharmaceuticals Inc Epinephrine dosing regimens
CN1827109A (zh) 2006-04-14 2006-09-06 北京润德康医药技术有限公司 一种以兰洛地尔及其盐为活性成分的冻干粉针制剂及其制备工艺
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
WO2008027382A2 (en) 2006-08-31 2008-03-06 Meridian Medical Technologies, Inc. Vortex feature for drug delivery system
US20080269347A1 (en) * 2006-09-28 2008-10-30 Azopharma, Inc. Epinephrine formulations
EP2152245B1 (en) 2007-04-30 2015-12-02 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US8057427B2 (en) 2007-05-09 2011-11-15 Meridian Medical Technologies, Inc. Drug delivery system with a small amount of a therapeutic agent
US7671270B2 (en) * 2007-07-30 2010-03-02 Emcore Solar Power, Inc. Solar cell receiver having an insulated bypass diode
US8177758B2 (en) 2008-04-08 2012-05-15 Rochester Area Consulting Engineers (RACE) Pneumatic injector
US10124117B2 (en) 2008-05-05 2018-11-13 Becton, Dickinson And Company Drug delivery device having cartridge with enlarged distal end
DE102008030270A1 (de) * 2008-06-19 2009-12-24 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Vorrichtung mit mindestens einer Kammer zur Aufnahme eines Medikaments oder eines Probenvolumens
GB2462811B (en) 2008-08-18 2012-08-15 Medical House Ltd Improved autoinjector
GB2467904B (en) 2009-02-17 2013-06-12 Oval Medical Technologies Ltd Drug container and delivery mechanism
JP5647232B2 (ja) 2009-05-18 2014-12-24 ザ スウォッチ グループ リサーチアンド ディベロップメント リミティド． 微小機械システムに適用される高い摩擦性能を維持しながら微小機械部品をコーティングする方法
PL2954914T3 (pl) 2009-05-29 2019-05-31 Tecpharma Licensing Ag Urządzenie wstrzykujące, zwłaszcza strzykawka automatyczna wyposażona w osłonę przed ukłuciem i/albo w zabezpieczenie pojemnika z produktem przed przeciążeniem
DK2437781T3 (da) 2009-06-04 2013-10-21 Alk Ag Stabiliseret sammensætning omfattende mindst én adrenerg forbindelse
GB2471304B (en) 2009-06-24 2013-12-11 Oval Medical Technologies Ltd A pre-filled syringe or autoinjector
RU2556340C2 (ru) 2009-07-31 2015-07-10 Санофи-Авентис Дойчланд Гмбх Композиция инсулина длительного действия
CN102389403B (zh) 2009-09-01 2012-11-28 广东隆赋药业有限公司 注射用单磷酸阿糖腺苷冻干粉针剂及其制备方法
WO2012012460A1 (en) 2010-07-19 2012-01-26 Xeris Pharmaceuticals, Inc. Stable glucagon formulations for the treatment of hypoglycemia
CA2829400C (en) 2011-03-10 2022-02-15 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of peptide drugs
CA2978588C (en) 2011-05-18 2019-12-31 Becton, Dickinson And Company Single-use injector of low cost
US9227017B2 (en) 2011-06-21 2016-01-05 Windgap Medical, Llc Automatic mixing device and delivery system
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
GB2499612A (en) 2012-02-22 2013-08-28 Consort Medical Plc Syringe assembly with a stopper
WO2013169800A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9522235B2 (en) * 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
WO2014026694A1 (en) 2012-08-14 2014-02-20 Injector Aps Disposable injector
CA2887296C (en) 2012-10-12 2018-12-04 Eli Lilly And Company Chemical engines and methods for their use, especially in the injection of highly viscous fluids
CN113730703A (zh) 2012-10-17 2021-12-03 椭元医疗技术有限公司 自动药物输送装置
WO2014066731A1 (en) 2012-10-26 2014-05-01 Massachusetts Institute Of Technology Rapid reconstitution packages for mixing and delivery of drugs
JP6560187B2 (ja) 2013-03-15 2019-08-14 ウインドギャップ メディカル インコーポレイテッド 携帯型薬剤混合及び送達システム並びに方法
US20140276413A1 (en) 2013-03-15 2014-09-18 Jeff Baker Medicament delivery and simulation system with a removable disposable container for medicament and a rotatable actuation component
AT514484B1 (de) 2013-06-24 2015-05-15 Pharma Consult Gmbh Aktivator für einen Autoinjektor
JP2017503017A (ja) 2013-12-18 2017-01-26 ウィンドギャップ メディカル， インコーポレイテッド 薬物混合および送達システムならびに方法
AU2015364280A1 (en) 2014-12-18 2017-07-06 Windgap Medical, Inc. Method and compositions for dissolving or solubilizing therapeutic agents
CN107543273B (zh) 2017-07-14 2019-05-28 大连理工大学 一种双箱体通风净化器

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AU2014364433A1 (en) 2016-08-04
AU2021200878A1 (en) 2021-03-04
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US12239823B2 (en) 2025-03-04
AU2021200878B2 (en) 2024-07-11
JP2019065043A (ja) 2019-04-25
JP2023057163A (ja) 2023-04-20
JP2017503017A (ja) 2017-01-26
US20150231334A1 (en) 2015-08-20
CA2934538A1 (en) 2015-06-25
CN113230486A (zh) 2021-08-10
CN106061253A (zh) 2016-10-26
EP3082419A4 (en) 2017-09-20
EP3082419A2 (en) 2016-10-26
US20230088439A1 (en) 2023-03-23
JP2021063134A (ja) 2021-04-22
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