CA2931051A1 - Piperidine derivatives having multimodal activity against pain - Google Patents

Piperidine derivatives having multimodal activity against pain Download PDF

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Publication number
CA2931051A1
CA2931051A1 CA2931051A CA2931051A CA2931051A1 CA 2931051 A1 CA2931051 A1 CA 2931051A1 CA 2931051 A CA2931051 A CA 2931051A CA 2931051 A CA2931051 A CA 2931051A CA 2931051 A1 CA2931051 A1 CA 2931051A1
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
methyl
piperidin
triazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2931051A
Other languages
English (en)
French (fr)
Inventor
Felix Cuevas Cordobes
Carmen ALMANSA-ROSALES
Monica Garcia Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of CA2931051A1 publication Critical patent/CA2931051A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2931051A 2013-12-20 2014-12-19 Piperidine derivatives having multimodal activity against pain Abandoned CA2931051A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13384004 2013-12-20
EP13384004.1 2013-12-20
PCT/EP2014/078717 WO2015091939A1 (en) 2013-12-20 2014-12-19 Piperidine derivatives having multimodal activity against pain

Publications (1)

Publication Number Publication Date
CA2931051A1 true CA2931051A1 (en) 2015-06-25

Family

ID=49998040

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2931051A Abandoned CA2931051A1 (en) 2013-12-20 2014-12-19 Piperidine derivatives having multimodal activity against pain

Country Status (7)

Country Link
US (1) US9981942B2 (cg-RX-API-DMAC7.html)
EP (1) EP3083601B1 (cg-RX-API-DMAC7.html)
JP (1) JP2017502010A (cg-RX-API-DMAC7.html)
CN (1) CN105849096B (cg-RX-API-DMAC7.html)
CA (1) CA2931051A1 (cg-RX-API-DMAC7.html)
MX (1) MX2016006604A (cg-RX-API-DMAC7.html)
WO (1) WO2015091939A1 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2991937A1 (en) * 2015-07-29 2017-02-02 Laboratorios Del Dr. Esteve, S.A. Substituted amide derivatives having multimodal activity against pain
HK1255248A1 (zh) 2015-07-29 2019-08-09 Esteve Pharmaceuticals, S.A. 对疼痛具有多模式活性的酰胺衍生物
ES2823588T3 (es) * 2016-05-20 2021-05-07 Esteve Pharmaceuticals Sa Derivados de tetrahidropirano que tienen actividad multimodal contra el dolor
EA201990069A1 (ru) 2016-06-21 2019-06-28 ОРИОН ОФТАЛМОЛОДЖИ ЭлЭлСи Производные гетероциклического пролинамида
US10526315B2 (en) 2016-06-21 2020-01-07 Orion Ophthalmology LLC Carbocyclic prolinamide derivatives
EP3570838B1 (en) 2017-01-17 2024-06-05 Mebias Discovery, Inc. Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
JP7013048B2 (ja) * 2018-03-02 2022-01-31 国立大学法人大阪大学 タンパク質及び／又はペプチド修飾用分子
TW202304448A (zh) * 2021-04-07 2023-02-01 西班牙商塔拉森斯調節公司 作為西格瑪配位基的新（高）哌啶基雜環
AU2023220657A1 (en) * 2022-02-16 2024-08-08 Duke Street Bio Limited Pharmaceutical compound
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL275537A (cg-RX-API-DMAC7.html) * 1961-03-06
DE2109155A1 (en) * 1971-02-26 1972-09-14 CH. Boehringer Sohn, 6507 Ingelheim 1-furylmethyl-4-phenyl-4-methoxycarbonylpiperidines - - with analgesic activity anorectic activity salt
GB9912410D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US6727264B1 (en) * 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists
PL366624A1 (en) * 2001-07-05 2005-02-07 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as mch selective antagonists
US7381721B2 (en) 2003-03-17 2008-06-03 Adolor Corporation Substituted piperidine compounds
JPWO2005100341A1 (ja) 2004-04-15 2008-03-06 アステラス製薬株式会社 ２−アミノピリミジン誘導体
US7645755B2 (en) * 2004-10-22 2010-01-12 Janssen Pharmaceutical N.V. Inhibitors of c-fms kinase
BRPI0614692A2 (pt) * 2005-07-29 2009-05-19 Hoffmann La Roche derivados de indol-3-il-carbonil-piperidina e piperazina
JP5182088B2 (ja) * 2006-04-19 2013-04-10 アステラス製薬株式会社 アゾールカルボキサミド誘導体
AU2007273057A1 (en) * 2006-07-12 2008-01-17 Merck Sharp & Dohme Corp. Substituted pyrazoles as ghrelin receptor antagonists
US7842696B2 (en) 2007-06-21 2010-11-30 Forest Laboratories Holdings Limited Piperazine derivatives as inhibitors of stearoyl-CoA desaturase
EP2195313B1 (en) * 2007-08-27 2014-04-02 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
JP2011502991A (ja) * 2007-11-02 2011-01-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 骨癌並びに骨癌に伴う骨喪失及び骨痛の処置又は予防のためのｃｆｍｓ阻害物質の使用
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds
JP5683489B2 (ja) 2009-01-12 2015-03-11 アレイ バイオファーマ、インコーポレイテッド ピペリジン含有化合物およびその用途
GB2474748B (en) * 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
EP3263583A1 (en) 2010-02-12 2018-01-03 Pharmascience Inc. Iap bir domain binding compounds
MX2016006603A (es) 2013-12-20 2016-09-06 Esteve Labor Dr Compuestos piperidinicos con actividad multimodal contra el dolor.

Also Published As

Publication number Publication date
JP2017502010A (ja) 2017-01-19
EP3083601A1 (en) 2016-10-26
EP3083601B1 (en) 2020-09-09
MX2016006604A (es) 2016-09-08
CN105849096B (zh) 2019-11-29
CN105849096A (zh) 2016-08-10
WO2015091939A1 (en) 2015-06-25
US20170001978A1 (en) 2017-01-05
US9981942B2 (en) 2018-05-29

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210309

FZDE Discontinued

Effective date: 20210309