CA2931013C - Nucleic acid probe and method of detecting genomic fragments - Google Patents
Nucleic acid probe and method of detecting genomic fragments Download PDFInfo
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- CA2931013C CA2931013C CA2931013A CA2931013A CA2931013C CA 2931013 C CA2931013 C CA 2931013C CA 2931013 A CA2931013 A CA 2931013A CA 2931013 A CA2931013 A CA 2931013A CA 2931013 C CA2931013 C CA 2931013C
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- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/501—Ligase
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- C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
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- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
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- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/30—Oligonucleotides characterised by their secondary structure
- C12Q2525/301—Hairpin oligonucleotides
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- C12Q2525/30—Oligonucleotides characterised by their secondary structure
- C12Q2525/307—Circular oligonucleotides
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- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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| PCT/IB2014/003061 WO2015083001A2 (en) | 2013-12-02 | 2014-11-26 | Nucleic acid probe and method of detecting genomic fragments |
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| GB2520763A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Nucleic acid probe and method of detecting genomic fragments |
| US10174383B2 (en) | 2014-08-13 | 2019-01-08 | Vanadis Diagnostics | Method of estimating the amount of a methylated locus in a sample |
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| EP3670671B1 (en) * | 2015-09-18 | 2023-07-26 | Vanadis Diagnostics | Probe set for analyzing a dna sample and method for using the same |
| JPWO2017135383A1 (ja) * | 2016-02-03 | 2018-12-06 | 国立大学法人豊橋技術科学大学 | 偽環状二重鎖ポリヌクレオチドと、それを用いた遺伝子発現阻害剤 |
| US10781476B2 (en) * | 2016-10-27 | 2020-09-22 | Vanadis Diagnostics | Method for processing rolling circle amplification products |
| WO2018214036A1 (zh) * | 2017-05-23 | 2018-11-29 | 深圳华大基因股份有限公司 | 基于滚环扩增的基因组目标区域富集方法及其应用 |
| US11117128B2 (en) | 2017-08-25 | 2021-09-14 | Vanadis Diagnostics Ab | Filtration device |
| CN112166199B (zh) | 2018-04-02 | 2025-04-29 | 埃努梅拉分子股份有限公司 | 用于对核酸分子进行计数的方法、系统和组合物 |
| JP7393429B2 (ja) * | 2018-12-05 | 2023-12-06 | 深▲せん▼華大智造極創科技有限公司 | ローリングサークル増幅方法、シーケンシングライブラリの調製方法及び調製されたｄｎａナノスフィア |
| CN109652506A (zh) * | 2018-12-20 | 2019-04-19 | 派德洛格(天津)生物科技有限公司 | 荧光原位检测人EGFR基因21号外显子p.L858R突变的方法及试剂盒 |
| EP3947718A4 (en) | 2019-04-02 | 2022-12-21 | Enumera Molecular, Inc. | METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES |
| US20230242971A1 (en) * | 2020-05-08 | 2023-08-03 | Roche Sequencing Solutions, Inc. | Removal of excess oligonucleotides from a reation mixture |
| US20230340578A1 (en) * | 2020-07-08 | 2023-10-26 | Roche Sequencing Solutions, Inc. | Spatial analysis of multiple targets in tissue samples |
| US12497651B2 (en) | 2020-11-23 | 2025-12-16 | Pleno, Inc. | Encoded dual-probe endonuclease assays |
| WO2022212559A1 (en) * | 2021-03-31 | 2022-10-06 | Jumpcode Genomics, Inc. | Methods for targeted nucleic acid sequencing |
| CN117377775A (zh) * | 2021-04-29 | 2024-01-09 | 因美纳有限公司 | 用于核酸表征的扩增技术 |
| EP4349984A1 (en) * | 2021-07-08 | 2024-04-10 | Kyushu University, National University Corporation | Probe, probe set, and nucleic acid detection kit for mammals |
| CN118369440A (zh) * | 2021-09-03 | 2024-07-19 | 麦克诺玛公司 | 鉴定癌症相关微生物生物标志物的方法 |
| GB202213930D0 (en) * | 2022-09-23 | 2022-11-09 | Xu Bo | Padlock blocking oligonucleotide |
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| DE602004026338D1 (de) * | 2003-11-04 | 2010-05-12 | Applied Biosystems Llc | Konkatamere ligationsprodukte: zusammensetzungen, verfahren und kits dafür |
| SE0401270D0 (sv) | 2004-05-18 | 2004-05-18 | Fredrik Dahl | Method for amplifying specific nucleic acids in parallel |
| WO2006076650A2 (en) | 2005-01-12 | 2006-07-20 | Applera Corporation | Compositions, methods, and kits for selective amplification of nucleic acids |
| US7645576B2 (en) | 2005-03-18 | 2010-01-12 | The Chinese University Of Hong Kong | Method for the detection of chromosomal aneuploidies |
| PL1899488T3 (pl) * | 2005-07-04 | 2016-03-31 | Erasmus Univ Medical Center | Test uchwytu konformacji chromosomu na czipie (4C) |
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| US8038595B2 (en) | 2006-01-25 | 2011-10-18 | Beth Israel Deaconess Medical Center | Devices and methods for tissue transplant and regeneration |
| US7901884B2 (en) * | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
| WO2008033442A2 (en) * | 2006-09-12 | 2008-03-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for performing low background multiplex nucleic acid amplification reactions |
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| GB2492042B (en) | 2011-05-11 | 2020-04-15 | Agilent Technologies Inc | Selector probes for nucleic acid analysis comprising at each end a non-adjacent target specific region |
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| CN104093854A (zh) * | 2011-12-02 | 2014-10-08 | 凯杰有限公司 | 表征组合物中的rna的方法和试剂盒 |
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| CN105074007A (zh) | 2013-03-12 | 2015-11-18 | 考希尔股份有限公司 | 用于产前遗传分析的系统和方法 |
| GB2520763A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Nucleic acid probe and method of detecting genomic fragments |
| GB2520765A (en) * | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Multiplex detection of nucleic acids |
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2013
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2014
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