CA2929547C - Assays for igfbp7 having improved performance in biological samples - Google Patents

Assays for igfbp7 having improved performance in biological samples Download PDF

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Publication number
CA2929547C
CA2929547C CA2929547A CA2929547A CA2929547C CA 2929547 C CA2929547 C CA 2929547C CA 2929547 A CA2929547 A CA 2929547A CA 2929547 A CA2929547 A CA 2929547A CA 2929547 C CA2929547 C CA 2929547C
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Canada
Prior art keywords
antibody
seq
igfbp7
antibodies
human
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Active
Application number
CA2929547A
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English (en)
French (fr)
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CA2929547A1 (en
Inventor
Ravi A. Vijayendran
Srivatsa Venkatasubbarao
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Astute Medical Inc
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Astute Medical Inc
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Publication date
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Priority to CA3185700A priority Critical patent/CA3185700A1/en
Publication of CA2929547A1 publication Critical patent/CA2929547A1/en
Application granted granted Critical
Publication of CA2929547C publication Critical patent/CA2929547C/en
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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4745Insulin-like growth factor binding protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/34Genitourinary disorders
    • G01N2800/347Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2929547A 2013-11-06 2014-11-06 Assays for igfbp7 having improved performance in biological samples Active CA2929547C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3185700A CA3185700A1 (en) 2013-11-06 2014-11-06 Assays for igfbp7 having improved performance in biological samples

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361900942P 2013-11-06 2013-11-06
US61/900,942 2013-11-06
US201462054324P 2014-09-23 2014-09-23
US62/054,324 2014-09-23
US201462064380P 2014-10-15 2014-10-15
US62/064,380 2014-10-15
PCT/US2014/064327 WO2015069880A1 (en) 2013-11-06 2014-11-06 Assays for igfbp7 having improved performance in biological samples

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3185700A Division CA3185700A1 (en) 2013-11-06 2014-11-06 Assays for igfbp7 having improved performance in biological samples

Publications (2)

Publication Number Publication Date
CA2929547A1 CA2929547A1 (en) 2015-05-14
CA2929547C true CA2929547C (en) 2023-02-28

Family

ID=53042071

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2929547A Active CA2929547C (en) 2013-11-06 2014-11-06 Assays for igfbp7 having improved performance in biological samples
CA3185700A Pending CA3185700A1 (en) 2013-11-06 2014-11-06 Assays for igfbp7 having improved performance in biological samples

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3185700A Pending CA3185700A1 (en) 2013-11-06 2014-11-06 Assays for igfbp7 having improved performance in biological samples

Country Status (12)

Country Link
US (3) US9822172B2 (Direct)
EP (2) EP3556863B1 (Direct)
JP (4) JP2017501211A (Direct)
KR (1) KR102404285B1 (Direct)
CN (1) CN105793439B (Direct)
AU (1) AU2014346695B2 (Direct)
BR (1) BR112016010106A2 (Direct)
CA (2) CA2929547C (Direct)
EA (1) EA201690731A1 (Direct)
HK (1) HK1221490A1 (Direct)
MX (1) MX375701B (Direct)
WO (1) WO2015069880A1 (Direct)

Families Citing this family (15)

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AU2009308497B2 (en) 2008-10-21 2014-10-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EA201290387A1 (ru) 2009-12-20 2013-02-28 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
NZ605698A (en) 2010-06-23 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US10935548B2 (en) 2011-12-08 2021-03-02 Astute Medical, Inc. Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2
TR201807542T4 (tr) 2013-01-17 2018-06-21 Astute Medical Inc Böbrek hasarı ve böbrek yetmezliği teşhisi ve prognozuna yönelik metotlar ve bileşimler.
US10300108B2 (en) 2013-12-03 2019-05-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BR112017005554A2 (en) * 2014-10-29 2018-01-23 F. Hoffmann-La Roche Ag methods for predicting a subject's risk of rapid progression to chronic heart failure and uses of at least one biomarker and at least one binding agent
EP3281011B1 (en) 2015-04-09 2024-06-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3359966B1 (en) * 2015-10-08 2020-01-01 Roche Diagnostics GmbH Igfbp7 for prediction of risk of aki when measured prior to surgery
US11243217B2 (en) 2016-06-06 2022-02-08 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
WO2018145117A1 (en) 2017-02-06 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2018187453A1 (en) 2017-04-05 2018-10-11 Astute Medical, Inc. Assays for timp2 having improved performance in biological samples
US11435364B2 (en) 2018-05-24 2022-09-06 Renibus Therapeutics, Inc. Methods of treating patients at risk for renal injury and renal failure
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KR102533791B1 (ko) * 2022-09-15 2023-05-18 경북대학교 산학협력단 비색법 신호형질 복합체, 이를 이용하는 신장질환 진단용 키트 및 진단법

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Also Published As

Publication number Publication date
EP3066221A1 (en) 2016-09-14
EP3556863A1 (en) 2019-10-23
CA3185700A1 (en) 2015-05-14
HK1221490A1 (zh) 2017-06-02
CA2929547A1 (en) 2015-05-14
US10562961B2 (en) 2020-02-18
AU2014346695A1 (en) 2016-06-16
US20180066045A1 (en) 2018-03-08
US20200247879A1 (en) 2020-08-06
AU2014346695B2 (en) 2020-10-15
KR20160068988A (ko) 2016-06-15
US20160289308A1 (en) 2016-10-06
JP7277623B2 (ja) 2023-05-19
MX2016005834A (es) 2016-11-17
JP2020048569A (ja) 2020-04-02
CN105793439B (zh) 2020-09-04
JP2022068143A (ja) 2022-05-09
US9822172B2 (en) 2017-11-21
JP2023052239A (ja) 2023-04-11
WO2015069880A1 (en) 2015-05-14
EA201690731A1 (ru) 2016-10-31
JP2017501211A (ja) 2017-01-12
MX375701B (es) 2025-03-06
CN105793439A (zh) 2016-07-20
EP3556863B1 (en) 2024-09-18
EP3066221A4 (en) 2017-09-20
BR112016010106A2 (pt) 2017-12-05
KR102404285B1 (ko) 2022-05-31

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