CA2926853C - Methods and compositions comprising a combination of a vegf antagonist and an anti-ctla-4 antibody - Google Patents
Methods and compositions comprising a combination of a vegf antagonist and an anti-ctla-4 antibody Download PDFInfo
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- CA2926853C CA2926853C CA2926853A CA2926853A CA2926853C CA 2926853 C CA2926853 C CA 2926853C CA 2926853 A CA2926853 A CA 2926853A CA 2926853 A CA2926853 A CA 2926853A CA 2926853 C CA2926853 C CA 2926853C
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- antibody
- ctla
- tumor
- vegf
- vegf antagonist
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Landscapes
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| EP2766043A4 (en) | 2011-10-13 | 2015-06-10 | Aerpio Therapeutics Inc | METHOD FOR THE TREATMENT OF CAPILLARY LECKSYNDROME AND CANCER |
| CN112626125A (zh) | 2014-03-17 | 2021-04-09 | 阿德夫拉姆生物技术股份有限公司 | 用于视锥细胞中增强的基因表达的组合物和方法 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| US11021519B2 (en) | 2015-03-02 | 2021-06-01 | Adverum Biotechnologies, Inc. | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| MA44594B1 (fr) | 2015-05-29 | 2020-09-30 | Memorial Sloan Kettering Cancer Center | Anticorps anti-ctla-4 et méthodes d'utilisation de ceux-ci |
| WO2017106462A1 (en) * | 2015-12-18 | 2017-06-22 | Biogen Ma Inc. | Bispecific antibody platform |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
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| KR20190031246A (ko) | 2016-07-20 | 2019-03-25 | 에르피오 세러퓨틱스 인코포레이티드 | VE-PTP (HPTP-β)를 표적으로 하는 인간화된 단클론성 항체 |
| IL307242A (en) | 2016-12-07 | 2023-11-01 | Agenus Inc | Anti-CTLA-4 antibodies and methods of using them |
| WO2018144587A1 (en) * | 2017-01-31 | 2018-08-09 | Research Development Foundation | Steap2 inhibitors for the treatment of liver cancers |
| MA50908A (fr) | 2017-11-17 | 2020-09-23 | Amgen Inc | Formulations de protéines de fusion vegfr-fc |
| WO2019152423A1 (en) * | 2018-02-02 | 2019-08-08 | Oncoimmune, Inc. | Mutant anti-ctla-4 antibodies with improved immunotherapeutic effect but attenuated adverse effects |
| CA3089704A1 (en) * | 2018-02-02 | 2019-08-08 | Oncoimmune, Inc. | Methods of selecting and designing safer and more effective anti-ctla-4 antibodies for cancer therapy |
| JP2021514656A (ja) * | 2018-03-02 | 2021-06-17 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | Ｉｌ−６抗体ならびにその融合構築物およびコンジュゲート |
| SG11202010589YA (en) | 2018-05-14 | 2020-11-27 | Oncoimmune Inc | Anti-cd24 compositions and uses thereof |
| CN113164597B (zh) | 2018-09-24 | 2025-02-28 | 视点制药公司 | 靶向HPTP-β（VE-PTP）和VEGF的多特异性抗体 |
| BR112021008060A2 (pt) * | 2018-10-31 | 2021-11-23 | Bioatla Inc | Polipeptídeo, anticorpo anti-ctla4 ou fragmento de anticorpo, imunoconjugado, composição farmacêutica, dose única de composição farmacêutica, método de tratar câncer, e, kit para diagnóstico ou tratamento |
| CN111378044B (zh) * | 2018-12-28 | 2022-07-15 | 长春金赛药业有限责任公司 | 抗体融合蛋白、制备方法及其应用 |
| AU2020216368B2 (en) * | 2019-01-30 | 2025-04-24 | Amgen Inc. | Aflibercept attributes and methods of characterizing and modifying thereof |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
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| DE19802753A1 (de) * | 1998-01-26 | 1999-07-29 | Merck Patent Gmbh | Coreaktive Trägermaterialien zur Heterogenisierung von Katalysatoren, Cokatalysatoren und Liganden |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| US7303746B2 (en) * | 1999-06-08 | 2007-12-04 | Regeneron Pharmaceuticals, Inc. | Methods of treating eye disorders with modified chimeric polypeptides |
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| AU784012B2 (en) | 1999-08-24 | 2006-01-12 | E. R. Squibb & Sons, L.L.C. | Human CTLA-4 antibodies and their uses |
| IL149701A0 (en) * | 2001-05-23 | 2002-11-10 | Pfizer Prod Inc | Use of anti-ctla-4 antibodies |
| CN101052655A (zh) * | 2004-11-04 | 2007-10-10 | 辉瑞产品有限公司 | 用于治疗乳腺癌的ctla4抗体和芳香酶抑制剂组合物 |
| CA2647282A1 (en) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| EP2212432A4 (en) * | 2007-10-22 | 2011-10-19 | Schering Corp | COMPLETELY HUMAN ANTI-VEGF ANTIBODIES AND USE PROCEDURES |
| EP2240204A1 (en) | 2008-02-04 | 2010-10-20 | Medarex, Inc. | Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
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2014
- 2014-10-17 JP JP2016524116A patent/JP6607850B2/ja active Active
- 2014-10-17 CN CN201480054902.1A patent/CN105636986B/zh active Active
- 2014-10-17 WO PCT/US2014/061071 patent/WO2015058048A1/en not_active Ceased
- 2014-10-17 KR KR1020167013164A patent/KR102338453B1/ko active Active
- 2014-10-17 CA CA2926853A patent/CA2926853C/en active Active
- 2014-10-17 MX MX2016004736A patent/MX377714B/es active IP Right Grant
- 2014-10-17 EP EP14792686.9A patent/EP3057990B1/en active Active
- 2014-10-17 US US15/026,460 patent/US9968674B2/en active Active
- 2014-10-17 EA EA201690633A patent/EA037890B1/ru unknown
- 2014-10-17 AU AU2014337135A patent/AU2014337135B2/en active Active
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|---|---|
| JP6607850B2 (ja) | 2019-11-20 |
| EA037890B1 (ru) | 2021-06-01 |
| WO2015058048A1 (en) | 2015-04-23 |
| KR20160067978A (ko) | 2016-06-14 |
| CN105636986A (zh) | 2016-06-01 |
| US10532096B2 (en) | 2020-01-14 |
| JP2016539096A (ja) | 2016-12-15 |
| US20180236070A1 (en) | 2018-08-23 |
| CN105636986B (zh) | 2020-05-12 |
| US20160243225A1 (en) | 2016-08-25 |
| AU2014337135B2 (en) | 2019-09-19 |
| IL244599A0 (en) | 2016-04-21 |
| EP3057990B1 (en) | 2019-09-04 |
| KR102338453B1 (ko) | 2021-12-13 |
| US9968674B2 (en) | 2018-05-15 |
| MX377714B (es) | 2025-03-11 |
| IL244599B (en) | 2019-10-31 |
| MX2016004736A (es) | 2016-07-26 |
| EP3057990A1 (en) | 2016-08-24 |
| EA201690633A1 (ru) | 2016-08-31 |
| CA2926853A1 (en) | 2015-04-23 |
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