CA2917492C - Beta-casein a2 and reducing or preventing symptoms of lactose intolerance - Google Patents

Beta-casein a2 and reducing or preventing symptoms of lactose intolerance Download PDF

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Publication number
CA2917492C
CA2917492C CA2917492A CA2917492A CA2917492C CA 2917492 C CA2917492 C CA 2917492C CA 2917492 A CA2917492 A CA 2917492A CA 2917492 A CA2917492 A CA 2917492A CA 2917492 C CA2917492 C CA 2917492C
Authority
CA
Canada
Prior art keywords
casein
beta
milk
lactose
symptoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2917492A
Other languages
English (en)
French (fr)
Other versions
CA2917492A1 (en
Inventor
Andrew John CLARKE
Malav Suchin TRIVEDI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A2 Milk Co Ltd
Original Assignee
A2 Milk Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52280344&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2917492(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by A2 Milk Co Ltd filed Critical A2 Milk Co Ltd
Priority to CA3214545A priority Critical patent/CA3214545A1/en
Publication of CA2917492A1 publication Critical patent/CA2917492A1/en
Application granted granted Critical
Publication of CA2917492C publication Critical patent/CA2917492C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Dairy Products (AREA)
  • Confectionery (AREA)
  • Peptides Or Proteins (AREA)
CA2917492A 2013-07-12 2014-07-10 Beta-casein a2 and reducing or preventing symptoms of lactose intolerance Active CA2917492C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3214545A CA3214545A1 (en) 2013-07-12 2014-07-10 Beta-casein a2 and reducing or preventing symptoms of lactose intolerance

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361845480P 2013-07-12 2013-07-12
US61/845,480 2013-07-12
PCT/NZ2014/000141 WO2015005804A1 (en) 2013-07-12 2014-07-10 Beta-casein a2 and reducing or preventing symptoms of lactose intolerance

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3214545A Division CA3214545A1 (en) 2013-07-12 2014-07-10 Beta-casein a2 and reducing or preventing symptoms of lactose intolerance

Publications (2)

Publication Number Publication Date
CA2917492A1 CA2917492A1 (en) 2015-01-15
CA2917492C true CA2917492C (en) 2023-11-14

Family

ID=52280344

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2917492A Active CA2917492C (en) 2013-07-12 2014-07-10 Beta-casein a2 and reducing or preventing symptoms of lactose intolerance
CA3214545A Pending CA3214545A1 (en) 2013-07-12 2014-07-10 Beta-casein a2 and reducing or preventing symptoms of lactose intolerance

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3214545A Pending CA3214545A1 (en) 2013-07-12 2014-07-10 Beta-casein a2 and reducing or preventing symptoms of lactose intolerance

Country Status (20)

Country Link
US (3) US20160136238A1 (https=)
EP (2) EP3542805A1 (https=)
JP (2) JP6436592B2 (https=)
KR (2) KR102367941B1 (https=)
CN (3) CN114832092A (https=)
AU (2) AU2014287862B2 (https=)
BR (1) BR112016000612B8 (https=)
CA (2) CA2917492C (https=)
CL (1) CL2016000064A1 (https=)
DK (1) DK3019180T3 (https=)
ES (1) ES2743194T3 (https=)
IL (2) IL243366B (https=)
MX (2) MX394585B (https=)
MY (2) MY190309A (https=)
NZ (2) NZ715985A (https=)
PH (2) PH12016500032B1 (https=)
RU (1) RU2671562C2 (https=)
SG (2) SG11201510707YA (https=)
WO (1) WO2015005804A1 (https=)
ZA (1) ZA201600007B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2742306T3 (es) * 2013-05-31 2020-02-13 A2 Milk Co Ltd Composición que comprende beta-caseína A2 para su uso en la prevención de la inflamación del intestino
EP3297643A4 (en) * 2015-05-22 2019-02-06 The A2 Milk Company Limited BETA-CASEIN-A2 AND ANTIOXIDATIVE CAPACITY
WO2017003300A1 (en) * 2015-06-29 2017-01-05 The A2 Milk Company Limited A2 beta-casein and viscosity of milk products
JP7394527B2 (ja) * 2016-03-30 2023-12-08 ズィ・エイツー・ミルク・カンパニー・リミテッド ベータカゼイン類および認知機能
WO2018063008A1 (en) 2016-09-30 2018-04-05 The A2 Milk Company Limited Beta-caseins and gut microbiota
NL2019906B1 (en) * 2017-11-14 2019-05-20 Ausnutria Hyproca B V Composition comprising a2 b-casein and a vegetable fat mixture
CN112205476A (zh) * 2019-07-11 2021-01-12 北京三元食品股份有限公司 β-酪蛋白A2、其组合物在促进双歧杆菌属增殖中的应用
WO2021003741A1 (zh) * 2019-07-11 2021-01-14 北京三元食品股份有限公司 β-酪蛋白A2、其组合物在促进双歧杆菌属增殖中的应用
WO2023010129A2 (en) * 2021-07-30 2023-02-02 Active Genomes Expressed Diagnostics, Corp. Methods and compositions for treating liver cancer and liver disease
CN121604896A (zh) * 2023-04-25 2026-03-03 艾尔牛奶有限公司 婴儿乳配方中的β-酪蛋白和在减少婴儿反流发作中的用途
WO2024225918A1 (en) * 2023-04-25 2024-10-31 The A2 Milk Company Limited Beta-caseins in infant milk formula and use for reducing crying episodes in infants
CN117322467A (zh) * 2023-10-11 2024-01-02 东北农业大学 A2β-酪蛋白在制备功能性食品中的应用
CN117322466A (zh) * 2023-11-02 2024-01-02 光明乳业股份有限公司 一种新型婴幼儿食用的发酵乳及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2204245C (en) 1994-11-04 2008-07-22 Robert Bartlett Elliott Method of selecting non-diabetogenic milk or milk products and milk or milk products so selected
CA2217820C (en) 1995-05-16 2011-03-01 Corran Norman Stuart Mclachlan Milk and milk products for preventing or treating heart disease
US7094949B2 (en) * 1995-05-16 2006-08-22 A2 Corporation Limited Breeding and milking cows for milk free of β-casein A1
US7029702B2 (en) * 1998-07-07 2006-04-18 Ritter Natural Sciences Llc Method for increasing lactose tolerance in mammals exhibiting lactose intolerance
AU771754B2 (en) 1999-06-29 2004-04-01 New Zealand Milk Institute Limited, The Prophylactic dietary supplement based on milk
AU9037401A (en) 2000-09-08 2002-03-22 New Zealand Dairy Board Milk containing beta-casein with proline at position 67 does not aggravate neurological disorders
US20060280802A1 (en) * 2002-10-04 2006-12-14 Campbell Julie H Therapeutic uses of beta-casein a2 and dietary supplement containing beta-casein a2
HUE044812T2 (hu) * 2003-09-23 2019-11-28 Dsm Ip Assets Bv Prolinspecifikus endoproteázok alkalmazása peptidek és fehérjék hidrolízisére
US7618669B2 (en) * 2005-06-01 2009-11-17 Mead Johnson Nutrition Company Low-lactose partially hydrolyzed infant formula
CN1899054A (zh) * 2006-07-17 2007-01-24 颜贻谦 去糖牛奶的制作方法
US20120093973A1 (en) * 2009-04-03 2012-04-19 Mukund Parthasarathy Milk-like beverages
AU2010238184B2 (en) * 2009-04-15 2014-09-04 Glanbia Nutritionals (Ireland) Limited A reduced lactose milk product and a process for the preparation thereof
DE102010009582A1 (de) * 2010-02-05 2011-08-11 Vitacare GmbH & Co. KG, 60318 Mittel zur Anwendung bei Lactasemangel und Lactoseintoleranz
MX389785B (es) * 2011-07-26 2025-03-18 Nucitec Sa De Cv Composicion nutrimental para niños que presentan reflujo, colico y/o estreñimiento.
CN103315063A (zh) * 2012-03-19 2013-09-25 基斯有限公司 可预防疾病的婴儿配方奶粉
ES2742306T3 (es) * 2013-05-31 2020-02-13 A2 Milk Co Ltd Composición que comprende beta-caseína A2 para su uso en la prevención de la inflamación del intestino
US20170086481A1 (en) * 2014-06-03 2017-03-30 Abbott Laboratories Nutritional compositions comprising a lipophilic active ingredient

Also Published As

Publication number Publication date
RU2015156804A (ru) 2017-08-17
CA2917492A1 (en) 2015-01-15
WO2015005804A1 (en) 2015-01-15
SG10201710237PA (en) 2018-01-30
SG11201510707YA (en) 2016-01-28
IL261143A (en) 2018-10-31
AU2014287862A1 (en) 2016-02-11
PH12019550112A1 (en) 2020-09-14
KR20200085375A (ko) 2020-07-14
EP3019180A4 (en) 2017-03-08
KR20160030974A (ko) 2016-03-21
US20200147173A1 (en) 2020-05-14
JP6990154B2 (ja) 2022-01-12
CL2016000064A1 (es) 2016-12-16
PH12016500032A1 (en) 2016-03-28
MX2016000308A (es) 2016-11-14
CN110800803A (zh) 2020-02-18
RU2015156804A3 (https=) 2018-05-31
MX2019012446A (es) 2020-02-03
EP3019180A1 (en) 2016-05-18
DK3019180T3 (da) 2019-08-26
PH12016500032B1 (en) 2019-10-25
AU2019203684A1 (en) 2019-06-20
BR112016000612B1 (pt) 2021-11-03
RU2018131604A3 (https=) 2022-04-19
US20220175882A1 (en) 2022-06-09
HK1223846A1 (en) 2017-08-11
IL243366B (en) 2018-11-29
KR102291660B1 (ko) 2021-08-19
JP6436592B2 (ja) 2018-12-12
NZ715985A (en) 2022-09-30
BR112016000612A2 (https=) 2017-07-25
NZ754642A (en) 2022-09-30
RU2018131604A (ru) 2018-11-20
IL261143B (en) 2021-02-28
BR112016000612B8 (pt) 2022-02-22
CA3214545A1 (en) 2015-01-15
MY172939A (en) 2019-12-16
JP2018203753A (ja) 2018-12-27
MX394585B (es) 2025-03-04
KR102367941B1 (ko) 2022-02-24
JP2016523958A (ja) 2016-08-12
US20160136238A1 (en) 2016-05-19
EP3542805A1 (en) 2019-09-25
MY190309A (en) 2022-04-13
MX368912B (es) 2019-10-21
EP3019180B1 (en) 2019-05-29
RU2671562C2 (ru) 2018-11-02
AU2014287862B2 (en) 2019-07-11
AU2019203684B2 (en) 2021-08-05
ES2743194T3 (es) 2020-02-18
CN114832092A (zh) 2022-08-02
ZA201600007B (en) 2017-11-29
CN105431156A (zh) 2016-03-23

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