CA2913872C - A laglidadg homing endonuclease cleaving the t-cell receptor alpha gene and uses thereof - Google Patents

A laglidadg homing endonuclease cleaving the t-cell receptor alpha gene and uses thereof Download PDF

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Publication number
CA2913872C
CA2913872C CA2913872A CA2913872A CA2913872C CA 2913872 C CA2913872 C CA 2913872C CA 2913872 A CA2913872 A CA 2913872A CA 2913872 A CA2913872 A CA 2913872A CA 2913872 C CA2913872 C CA 2913872C
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seq
variant
sequence
cells
dna
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CA2913872A1 (en
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Alexander ASTRAKHAN
Jordan JARJOUR
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Cellectis SA
Precision Genome Engineering Inc
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Precision Genome Engineering Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2913872A 2013-05-31 2014-05-28 A laglidadg homing endonuclease cleaving the t-cell receptor alpha gene and uses thereof Active CA2913872C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201370303 2013-05-31
DKPA201370303 2013-05-31
PCT/EP2014/061189 WO2014191527A1 (en) 2013-05-31 2014-05-28 A laglidadg homing endonuclease cleaving the t cell receptor alpha gene and uses thereof

Publications (2)

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CA2913872A1 CA2913872A1 (en) 2014-12-04
CA2913872C true CA2913872C (en) 2022-01-18

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CA2913872A Active CA2913872C (en) 2013-05-31 2014-05-28 A laglidadg homing endonuclease cleaving the t-cell receptor alpha gene and uses thereof

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US (1) US10000746B2 (enExample)
EP (1) EP3004338B1 (enExample)
JP (1) JP6450371B2 (enExample)
AU (1) AU2014273091B2 (enExample)
CA (1) CA2913872C (enExample)
DK (1) DK3004338T3 (enExample)
ES (1) ES2716867T3 (enExample)
WO (1) WO2014191527A1 (enExample)

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Also Published As

Publication number Publication date
CA2913872A1 (en) 2014-12-04
JP2016520320A (ja) 2016-07-14
EP3004338B1 (en) 2019-01-02
US10000746B2 (en) 2018-06-19
US20160130569A1 (en) 2016-05-12
JP6450371B2 (ja) 2019-01-09
WO2014191527A1 (en) 2014-12-04
DK3004338T3 (en) 2019-04-08
HK1223394A1 (en) 2017-07-28
AU2014273091B2 (en) 2019-12-12
ES2716867T3 (es) 2019-06-17
EP3004338A1 (en) 2016-04-13
AU2014273091A1 (en) 2015-12-03

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