|
CA2832534C
(en)
*
|
2011-04-05 |
2022-01-04 |
Julien Valton |
Method for the generation of compact tale-nucleases and uses thereof
|
|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
|
EP4372090A3
(en)
|
2013-11-07 |
2024-08-07 |
Editas Medicine, Inc. |
Crispr-related methods and compositions with governing grnas
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
EP3092049A1
(en)
|
2014-01-08 |
2016-11-16 |
Flodesign Sonics Inc. |
Acoustophoresis device with dual acoustophoretic chamber
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
ES2883116T3
(es)
|
2015-10-05 |
2021-12-07 |
Prec Biosciences Inc |
Meganucleasas diseñadas con secuencias de reconocimiento encontradas en el gen de la región constante alfa del receptor de células T humanas
|
|
IL287319B2
(en)
*
|
2015-10-05 |
2023-02-01 |
Prec Biosciences Inc |
Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene
|
|
US12043852B2
(en)
|
2015-10-23 |
2024-07-23 |
President And Fellows Of Harvard College |
Evolved Cas9 proteins for gene editing
|
|
CN121294437A
(zh)
|
2015-12-04 |
2026-01-09 |
诺华股份有限公司 |
用于免疫肿瘤学的组合物和方法
|
|
KR102386029B1
(ko)
*
|
2016-03-11 |
2022-04-13 |
2세븐티 바이오, 인코포레이티드 |
게놈 편집 면역 효과기 세포
|
|
US10188749B2
(en)
|
2016-04-14 |
2019-01-29 |
Fred Hutchinson Cancer Research Center |
Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
|
|
CR20180503A
(es)
*
|
2016-04-14 |
2018-12-21 |
Hutchinson Fred Cancer Res |
Composiciones y métodos para programar células terapéuticas utilizando nanoportadores de ácidos nucleicos dirigidos
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
JP2019525759A
(ja)
*
|
2016-07-25 |
2019-09-12 |
ブルーバード バイオ, インコーポレイテッド |
Bcl11aホーミングエンドヌクレアーゼバリアント、組成物、および使用方法
|
|
CA3032699A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harvard College |
Adenosine nucleobase editors and uses thereof
|
|
CA3033327A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
CA3034094A1
(en)
|
2016-08-16 |
2018-02-22 |
Bluebird Bio, Inc. |
Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use
|
|
WO2018039333A1
(en)
*
|
2016-08-23 |
2018-03-01 |
Bluebird Bio, Inc. |
Tim3 homing endonuclease variants, compositions, and methods of use
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
SG11201901757YA
(en)
|
2016-09-08 |
2019-03-28 |
Bluebird Bio Inc |
Pd-1 homing endonuclease variants, compositions, and methods of use
|
|
RU2019114035A
(ru)
*
|
2016-10-11 |
2020-11-13 |
Блубёрд Био, Инк. |
ВАРИАНТЫ ХОМИНГ-ЭНДОНУКЛЕАЗЫ ТКРα
|
|
US11306324B2
(en)
|
2016-10-14 |
2022-04-19 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
WO2018075541A1
(en)
*
|
2016-10-17 |
2018-04-26 |
Bluebird Bio, Inc. |
TGFβR2 ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE
|
|
WO2018073393A2
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
|
|
JP7685735B2
(ja)
|
2016-12-02 |
2025-05-30 |
アンヘレス セラピューティクス インコーポレイテッド |
合成免疫受容体およびその使用方法
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
JP7348063B2
(ja)
|
2017-01-05 |
2023-09-20 |
フレッド ハッチンソン キャンサー センター |
ワクチン効力を改善するためのシステム及び方法
|
|
JP2020510038A
(ja)
|
2017-03-09 |
2020-04-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
がんワクチン
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
CN110914310A
(zh)
|
2017-03-10 |
2020-03-24 |
哈佛大学的校长及成员们 |
胞嘧啶至鸟嘌呤碱基编辑器
|
|
AU2018237159A1
(en)
|
2017-03-22 |
2019-09-05 |
Intellia Therapeutics, Inc. |
Compositions and methods for immunooncology
|
|
EP3601562A1
(en)
|
2017-03-23 |
2020-02-05 |
President and Fellows of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
US11767512B2
(en)
|
2017-04-13 |
2023-09-26 |
Cellectis |
Sequence specific reagents targeting CCR5 in primary hematopoietic cells
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
MA48797A
(fr)
*
|
2017-05-25 |
2020-04-08 |
Bluebird Bio Inc |
Variants de l'endonucléase cblb , compositions et procédés d'utilisation
|
|
JP2020529834A
(ja)
|
2017-06-30 |
2020-10-15 |
プレシジョン バイオサイエンシズ,インク. |
T細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変t細胞
|
|
JP2020534795A
(ja)
|
2017-07-28 |
2020-12-03 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物
|
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
|
US11779654B2
(en)
*
|
2017-10-04 |
2023-10-10 |
2Seventy Bio, Inc. |
PCSK9 endonuclease variants, compositions, and methods of use
|
|
US11788076B2
(en)
|
2017-10-10 |
2023-10-17 |
Hiroshima University |
Full replacement technique for T cell receptor using platinum TALEN
|
|
EP3702454A4
(en)
|
2017-10-10 |
2021-08-04 |
Hiroshima University |
TECHNIQUE FOR CREATING T-REGULATORY T-LYMPHOCYTES (TREG) SPECIFIC FOR AN ANTIGEN IN WHICH T-LYMPHOCYTE ANTIGEN RECEPTOR T EFFECTORS (TEFF) ARE USED
|
|
JP2021500036A
(ja)
|
2017-10-16 |
2021-01-07 |
ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. |
アデノシン塩基編集因子の使用
|
|
BR112020009889A2
(pt)
|
2017-12-14 |
2020-11-03 |
Flodesign Sonics, Inc. |
acionador e controlador de transdutor acústico
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019126555A1
(en)
*
|
2017-12-20 |
2019-06-27 |
Bluebird Bio, Inc. |
Ctla4 homing endonuclease variants, compositions, and methods of use
|
|
MX2020010795A
(es)
|
2018-04-12 |
2021-01-08 |
Prec Biosciences Inc |
Nucleasas modificadas genéticamente optimizadas que tienen especificidad para el gen de la región constante alfa del receptor de linfocitos t humanos.
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
AU2019287720B2
(en)
|
2018-06-14 |
2025-08-28 |
Regeneron Pharmaceuticals, Inc. |
CD79A chimeric antigen receptors
|
|
WO2020072059A1
(en)
*
|
2018-10-04 |
2020-04-09 |
Bluebird Bio, Inc. |
Cblb endonuclease variants, compositions, and methods of use
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
KR20210102925A
(ko)
|
2018-12-10 |
2021-08-20 |
블루버드 바이오, 인코포레이티드. |
호밍 엔도뉴클레아제 변이체
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
KR20210143230A
(ko)
|
2019-03-19 |
2021-11-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
뉴클레오티드 서열을 편집하기 위한 방법 및 조성물
|
|
IL316764A
(en)
|
2019-04-03 |
2025-01-01 |
Prec Biosciences Inc |
Genetically modified immune cells containing shRNA-targeted microRNA (shRNAmir)
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US20220273715A1
(en)
|
2019-07-25 |
2022-09-01 |
Precision Biosciences, Inc. |
Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus
|
|
WO2021035054A1
(en)
|
2019-08-20 |
2021-02-25 |
Precision Biosciences, Inc. |
Lymphodepletion dosing regimens for cellular immunotherapies
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021087305A1
(en)
|
2019-10-30 |
2021-05-06 |
Precision Biosciences, Inc. |
Cd20 chimeric antigen receptors and methods of use for immunotherapy
|
|
BR112022022603A2
(pt)
|
2020-05-08 |
2023-01-17 |
Broad Inst Inc |
Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla
|
|
EP4192875A1
(en)
|
2020-08-10 |
2023-06-14 |
Precision BioSciences, Inc. |
Antibodies and fragments specific for b-cell maturation antigen and uses thereof
|
|
JP2024503249A
(ja)
*
|
2020-12-21 |
2024-01-25 |
2セブンティ バイオ インコーポレイテッド |
部位特異的変異導入のための組成物及び方法
|
|
US20250127811A1
(en)
|
2021-01-28 |
2025-04-24 |
Precision Biosciences, Inc. |
Modulation of tgf beta signaling in genetically-modified eukaryotic cells
|
|
US20250043269A1
(en)
|
2021-11-03 |
2025-02-06 |
The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glad |
Precise Genome Editing Using Retrons
|
|
WO2023081767A1
(en)
|
2021-11-05 |
2023-05-11 |
Precision Biosciences, Inc. |
Methods for immunotherapy
|
|
KR20240110844A
(ko)
|
2021-11-23 |
2024-07-16 |
셀렉티스 에스.에이. |
개선된 온-타겟/오프-타겟 활성 비율을 갖는 신규 tale 단백질 스캐폴드
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2024148167A1
(en)
|
2023-01-05 |
2024-07-11 |
Precision Biosciences, Inc. |
Optimized engineered meganucleases having specificity for the human t cell receptor alpha constant region gene
|