CA2909479A1 - Method of determining the fraction of fetal dna in maternal blood using hla markers - Google Patents

Method of determining the fraction of fetal dna in maternal blood using hla markers Download PDF

Info

Publication number
CA2909479A1
CA2909479A1 CA2909479A CA2909479A CA2909479A1 CA 2909479 A1 CA2909479 A1 CA 2909479A1 CA 2909479 A CA2909479 A CA 2909479A CA 2909479 A CA2909479 A CA 2909479A CA 2909479 A1 CA2909479 A1 CA 2909479A1
Authority
CA
Canada
Prior art keywords
hla
maternal
exon
allele
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2909479A
Other languages
English (en)
French (fr)
Inventor
Henry A. Erlich
Bryan Hoglund
Cherie Holcomb
Priscilla Moonsamy
Nicolas Newton
Melinda RASTROU
Alison Tsan
Nancy Schoenbrunner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2909479A1 publication Critical patent/CA2909479A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2909479A 2013-05-09 2014-05-07 Method of determining the fraction of fetal dna in maternal blood using hla markers Abandoned CA2909479A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361821620P 2013-05-09 2013-05-09
US61/821,620 2013-05-09
US201361861316P 2013-08-01 2013-08-01
US61/861,316 2013-08-01
PCT/EP2014/059348 WO2014180910A1 (en) 2013-05-09 2014-05-07 Method of determining the fraction of fetal dna in maternal blood using hla markers

Publications (1)

Publication Number Publication Date
CA2909479A1 true CA2909479A1 (en) 2014-11-13

Family

ID=50680043

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2909479A Abandoned CA2909479A1 (en) 2013-05-09 2014-05-07 Method of determining the fraction of fetal dna in maternal blood using hla markers

Country Status (6)

Country Link
US (1) US20150203914A1 (https=)
EP (1) EP2994538A1 (https=)
JP (1) JP2016516449A (https=)
CN (1) CN105189787A (https=)
CA (1) CA2909479A1 (https=)
WO (1) WO2014180910A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
CN108256296B (zh) * 2017-12-29 2021-05-25 北京科迅生物技术有限公司 数据处理装置
RU2681488C1 (ru) * 2018-04-19 2019-03-06 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации Способ прогнозирования состояния плода человека накануне родов
EP3916105B1 (en) * 2019-08-14 2023-01-25 BGI Genomics Co., Limited Method and device for determining fetal nucleic acid concentration in blood of pregnant woman
PL445283A1 (pl) * 2023-06-20 2024-12-23 Instytut Centrum Zdrowia Matki Polki Sposób nieinwazyjnej analizy płodowego DNA oraz frakcji płodu z wykorzystaniem reakcji multipleks digital PCR

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
WO2004078999A1 (en) * 2003-03-05 2004-09-16 Genetic Technologies Limited Identification of fetal dna and fetal cell markers in maternal plasma or serum
US7867703B2 (en) 2004-08-26 2011-01-11 Agilent Technologies, Inc. Element defined sequence complexity reduction
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
US7835871B2 (en) 2007-01-26 2010-11-16 Illumina, Inc. Nucleic acid sequencing system and method
CN102124125A (zh) * 2007-10-16 2011-07-13 霍夫曼-拉罗奇有限公司 通过克隆性测序的高分辨率、高通量hla基因分型
US20100261189A1 (en) * 2008-10-03 2010-10-14 Roche Molecular Systems, Inc. System and method for detection of HLA Variants
LT3783110T (lt) * 2009-11-05 2023-01-25 The Chinese University Of Hong Kong Vaisiaus genomo analizė iš motinos biologinio mėginio
WO2012078792A2 (en) * 2010-12-07 2012-06-14 Stanford University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale

Also Published As

Publication number Publication date
EP2994538A1 (en) 2016-03-16
JP2016516449A (ja) 2016-06-09
US20150203914A1 (en) 2015-07-23
CN105189787A (zh) 2015-12-23
WO2014180910A1 (en) 2014-11-13

Similar Documents

Publication Publication Date Title
US9752189B2 (en) Non-invasive early detection of solid organ transplant rejection by quantitative analysis of mixtures by deep sequencing of HLA gene amplicons using next generation systems
JP6328934B2 (ja) 非侵襲性出生前親子鑑定法
CN103534591B (zh) 通过测序分析进行的非侵入性胎儿遗传筛选
US20080299562A1 (en) Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
Delahunty et al. Testing the feasibility of DNA typing for human identification by PCR and an oligonucleotide ligation assay
US11542556B2 (en) Single nucleotide polymorphism in HLA-B*15:02 and use thereof
HK1199067A1 (en) Non-invasive fetal genetic screening using targeted amplification and sequencing
GB2488358A (en) Enrichment of foetal DNA in maternal plasma
EP2010676A1 (en) Method and kit for molecular chromosomal quantification
CA2909479A1 (en) Method of determining the fraction of fetal dna in maternal blood using hla markers
CN106939334A (zh) 一种孕妇血浆中胎儿dna含量的检测方法
KR101761801B1 (ko) 코 표현형 판단용 조성물
WO2016008550A1 (en) Non-invasive early detection of solid organ transplant rejection by quantitative analysis of hla gene amplicons
US20060084095A1 (en) Compositions, methods, and systems for determining bovine parentage and identity
AU2020373281B2 (en) Method for identifying transplant donors for a transplant recipient
CN104024410A (zh) Hla-a*24组的判定方法
JP6245796B2 (ja) 原発性胆汁性肝硬変の発症リスク予測マーカー、プローブ、プライマー及びキット並びに原発性胆汁性肝硬変の発症リスク予測方法
US20140037549A1 (en) Genetic markers for prognosis of rheumatoid arthritis treatment efficacy

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20151014

FZDE Discontinued

Effective date: 20190122