CN105189787A - 使用hla标志物测定母体血液中的胎儿dna的分数的方法 - Google Patents

使用hla标志物测定母体血液中的胎儿dna的分数的方法 Download PDF

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Publication number
CN105189787A
CN105189787A CN201480026232.2A CN201480026232A CN105189787A CN 105189787 A CN105189787 A CN 105189787A CN 201480026232 A CN201480026232 A CN 201480026232A CN 105189787 A CN105189787 A CN 105189787A
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China
Prior art keywords
hla
exon
maternal
sample
allelotrope
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Pending
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CN201480026232.2A
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English (en)
Chinese (zh)
Inventor
H.A.厄利克
B.霍格伦
C.霍尔康布
P.蒙萨米
N.牛顿
M.拉斯特罗
A.詹
N.肖恩布伦纳
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN105189787A publication Critical patent/CN105189787A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201480026232.2A 2013-05-09 2014-05-07 使用hla标志物测定母体血液中的胎儿dna的分数的方法 Pending CN105189787A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361821620P 2013-05-09 2013-05-09
US61/821620 2013-05-09
US201361861316P 2013-08-01 2013-08-01
US61/861316 2013-08-01
PCT/EP2014/059348 WO2014180910A1 (en) 2013-05-09 2014-05-07 Method of determining the fraction of fetal dna in maternal blood using hla markers

Publications (1)

Publication Number Publication Date
CN105189787A true CN105189787A (zh) 2015-12-23

Family

ID=50680043

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480026232.2A Pending CN105189787A (zh) 2013-05-09 2014-05-07 使用hla标志物测定母体血液中的胎儿dna的分数的方法

Country Status (6)

Country Link
US (1) US20150203914A1 (https=)
EP (1) EP2994538A1 (https=)
JP (1) JP2016516449A (https=)
CN (1) CN105189787A (https=)
CA (1) CA2909479A1 (https=)
WO (1) WO2014180910A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108256296A (zh) * 2017-12-29 2018-07-06 北京科迅生物技术有限公司 数据处理方法及装置
WO2021026828A1 (zh) * 2019-08-14 2021-02-18 深圳华大基因股份有限公司 确定孕妇血液中胎儿核酸浓度的方法及设备

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
RU2681488C1 (ru) * 2018-04-19 2019-03-06 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации Способ прогнозирования состояния плода человека накануне родов
PL445283A1 (pl) * 2023-06-20 2024-12-23 Instytut Centrum Zdrowia Matki Polki Sposób nieinwazyjnej analizy płodowego DNA oraz frakcji płodu z wykorzystaniem reakcji multipleks digital PCR

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110105353A1 (en) * 2009-11-05 2011-05-05 The Chinese University of Hong Kong c/o Technology Licensing Office Fetal Genomic Analysis From A Maternal Biological Sample
CN102124125A (zh) * 2007-10-16 2011-07-13 霍夫曼-拉罗奇有限公司 通过克隆性测序的高分辨率、高通量hla基因分型
US20120196754A1 (en) * 2010-12-07 2012-08-02 Stanford University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
WO2004078999A1 (en) * 2003-03-05 2004-09-16 Genetic Technologies Limited Identification of fetal dna and fetal cell markers in maternal plasma or serum
US7867703B2 (en) 2004-08-26 2011-01-11 Agilent Technologies, Inc. Element defined sequence complexity reduction
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
US7835871B2 (en) 2007-01-26 2010-11-16 Illumina, Inc. Nucleic acid sequencing system and method
US20100261189A1 (en) * 2008-10-03 2010-10-14 Roche Molecular Systems, Inc. System and method for detection of HLA Variants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102124125A (zh) * 2007-10-16 2011-07-13 霍夫曼-拉罗奇有限公司 通过克隆性测序的高分辨率、高通量hla基因分型
US20110105353A1 (en) * 2009-11-05 2011-05-05 The Chinese University of Hong Kong c/o Technology Licensing Office Fetal Genomic Analysis From A Maternal Biological Sample
US20120196754A1 (en) * 2010-12-07 2012-08-02 Stanford University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FAN HC ET AL.: "Non-invasive prenatal measurement of the fetal genome", 《NATURE》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108256296A (zh) * 2017-12-29 2018-07-06 北京科迅生物技术有限公司 数据处理方法及装置
CN108256296B (zh) * 2017-12-29 2021-05-25 北京科迅生物技术有限公司 数据处理装置
WO2021026828A1 (zh) * 2019-08-14 2021-02-18 深圳华大基因股份有限公司 确定孕妇血液中胎儿核酸浓度的方法及设备

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Publication number Publication date
EP2994538A1 (en) 2016-03-16
CA2909479A1 (en) 2014-11-13
JP2016516449A (ja) 2016-06-09
US20150203914A1 (en) 2015-07-23
WO2014180910A1 (en) 2014-11-13

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Application publication date: 20151223