CA2890171C - A porous silica material for use as a pharmaceutical or dietary active ingredient - Google Patents

A porous silica material for use as a pharmaceutical or dietary active ingredient Download PDF

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Publication number
CA2890171C
CA2890171C CA2890171A CA2890171A CA2890171C CA 2890171 C CA2890171 C CA 2890171C CA 2890171 A CA2890171 A CA 2890171A CA 2890171 A CA2890171 A CA 2890171A CA 2890171 C CA2890171 C CA 2890171C
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CA
Canada
Prior art keywords
range
pores
formulation
pore size
dietary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2890171A
Other languages
English (en)
French (fr)
Other versions
CA2890171A1 (en
Inventor
Robert CSIKASZ
Tore Bengtsson
Natalia KUPFERSCHMIDT
Alfonso E. Garcia-Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIGRID THERAPEUTICS AB
Original Assignee
SIGRID THERAPEUTICS AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SIGRID THERAPEUTICS AB filed Critical SIGRID THERAPEUTICS AB
Priority to CA3024640A priority Critical patent/CA3024640A1/en
Publication of CA2890171A1 publication Critical patent/CA2890171A1/en
Application granted granted Critical
Publication of CA2890171C publication Critical patent/CA2890171C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/015—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/12—Surface area
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/14—Pore volume
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/16—Pore diameter
    • C01P2006/17—Pore diameter distribution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Silicon Compounds (AREA)
CA2890171A 2012-11-06 2013-11-06 A porous silica material for use as a pharmaceutical or dietary active ingredient Active CA2890171C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3024640A CA3024640A1 (en) 2012-11-06 2013-11-06 A porous silica material for use as a pharmaceutical or dietary active ingredient

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261723019P 2012-11-06 2012-11-06
US61/723,019 2012-11-06
PCT/EP2013/073200 WO2014072363A1 (en) 2012-11-06 2013-11-06 A porous silica material for use as a pharmaceutical or dietary active ingredient

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3024640A Division CA3024640A1 (en) 2012-11-06 2013-11-06 A porous silica material for use as a pharmaceutical or dietary active ingredient

Publications (2)

Publication Number Publication Date
CA2890171A1 CA2890171A1 (en) 2014-05-15
CA2890171C true CA2890171C (en) 2019-01-22

Family

ID=49639855

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2890171A Active CA2890171C (en) 2012-11-06 2013-11-06 A porous silica material for use as a pharmaceutical or dietary active ingredient
CA3024640A Abandoned CA3024640A1 (en) 2012-11-06 2013-11-06 A porous silica material for use as a pharmaceutical or dietary active ingredient
CA3024460A Pending CA3024460A1 (fr) 2012-11-06 2018-11-15 A porous silica material for use as a pharmaceutical or dietary active ingredient

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3024640A Abandoned CA3024640A1 (en) 2012-11-06 2013-11-06 A porous silica material for use as a pharmaceutical or dietary active ingredient
CA3024460A Pending CA3024460A1 (fr) 2012-11-06 2018-11-15 A porous silica material for use as a pharmaceutical or dietary active ingredient

Country Status (20)

Country Link
US (2) US10695294B2 (enExample)
EP (2) EP3892285A3 (enExample)
JP (2) JP6421124B2 (enExample)
CN (2) CN113069467A (enExample)
AU (1) AU2013343565B2 (enExample)
BR (1) BR112015010118A2 (enExample)
CA (3) CA2890171C (enExample)
CY (1) CY1124471T1 (enExample)
DK (1) DK2916852T3 (enExample)
ES (1) ES2878017T3 (enExample)
HR (1) HRP20211036T1 (enExample)
HU (1) HUE055017T2 (enExample)
IL (1) IL238538B (enExample)
LT (1) LT2916852T (enExample)
PH (1) PH12015501010B1 (enExample)
PL (1) PL2916852T3 (enExample)
PT (1) PT2916852T (enExample)
SI (1) SI2916852T1 (enExample)
WO (1) WO2014072363A1 (enExample)
ZA (1) ZA201502979B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE055017T2 (hu) 2012-11-06 2021-10-28 Sigrid Therapeutics Ab Pórusos szilíciumdioxid-anyag gyógyászati hatóanyagként vagy élelmiszerekben való alkalmazásra
NZ709368A (en) 2012-12-21 2020-01-31 National Health Res Inst Mesoporous silica nanoparticles for oil absorption
US20200129444A1 (en) * 2017-07-13 2020-04-30 Carnegie Mellon University Method of Increasing Epithelial Permeability Using Nanoparticles
EP3723721B1 (en) * 2017-12-13 2021-09-15 L.I.Co.Rice S.R.L. Complex of lactoferrin and silica, process for preparing and compositions for oral hygiene
GB201803363D0 (en) 2018-03-01 2018-04-18 Sigrid Therapeutics Ab New materials and uses thereof
PL3894857T3 (pl) * 2019-04-15 2023-01-09 Nanologica Ab Puste porowate cząstki do stosowania w leczeniu, zapobieganiu i/lub opóźnianiu degeneracyjności chorób neurodgeneracyjnych, neuronów i gleju
CN110314151B (zh) * 2019-08-02 2020-06-02 深圳国佳产业基金管理有限公司 医用介孔二氧化硅材料及其应用
CN114729263A (zh) * 2019-09-30 2022-07-08 零点火技术股份有限公司 隔热阻燃材料及其制造方法
JP7578945B2 (ja) * 2020-10-27 2024-11-07 信越化学工業株式会社 イミダゾールシラン処理シリカからなる胆汁酸吸着剤
CN114195885B (zh) * 2022-01-12 2024-04-26 杭州隆基生物技术有限公司 一种单克隆抗体组合物提纯方法
WO2023148307A1 (en) 2022-02-04 2023-08-10 Sigrid Therapeutics Ab Oral care composition comprising porous silica particles
JP2025119063A (ja) 2022-04-28 2025-08-14 日本たばこ産業株式会社 無機多孔質材料を含む口腔用組成物
GB202212240D0 (en) 2022-08-23 2022-10-05 Sigrid Therapeutics Ab New formulations and medical uses thereof
GB202212239D0 (en) 2022-08-23 2022-10-05 Sigrid Therapeutics Ab New dietary supplements
CN116747321B (zh) * 2023-06-14 2025-09-05 厦门君德医药科技有限公司 一种接枝改性的介孔二氧化硅及其制备方法和应用
GB202312179D0 (en) 2023-08-09 2023-09-20 Sigrid Therapeutics Ab New compositions and uses
GB202312176D0 (en) 2023-08-09 2023-09-20 Sigrid Therapeutics Ab New uses and methods

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185088A (en) 1977-02-17 1980-01-22 Merck & Co., Inc. Non-adhesive ionene quaternary polymer compositions useful as bile acid sequestrants
US4180566A (en) * 1978-05-15 1979-12-25 W. R. Grace & Co. Silica gel method of reducing blood lipid concentration
US4824672A (en) * 1986-06-06 1989-04-25 Hauser-Kuhrts, Inc. Method and composition for reducing serum cholesterol
US5401466A (en) * 1993-06-01 1995-03-28 Miles Inc. Device for the direct measurement of low density lipoprotein cholesterol
EP0778027A3 (de) 1995-12-04 1998-04-01 Helmut Univ.-Prof. Dr. Wachter Verwendung von Kieselerde zur Herstellung von Arzneimitteln
EP0911078A1 (en) * 1997-10-20 1999-04-28 Hitachi Metals, Ltd. Photocatalyst-supporting body and photocatalytic apparatus
ID27415A (id) * 1998-06-30 2001-04-05 Takeda Chemical Industries Ltd Komposisi farmaseutik
AU7881000A (en) * 1999-08-16 2001-03-13 Henceforth Hibernia, Inc. Therapeutic and prophylactic compositions including catalytic biomimetic solids and methods to prepare and use them
DE60106623T2 (de) 2000-07-28 2006-02-02 F. Hoffmann-La Roche Ag Neue pharmazeutische zusammensetzung
US7074440B2 (en) * 2002-05-01 2006-07-11 Rulin Xiu Compositions and methods for body weight loss
JP2004345895A (ja) * 2003-05-21 2004-12-09 Ajinomoto Co Inc メソポーラスシリカ及びその製造方法
JP2005289853A (ja) * 2004-03-31 2005-10-20 Ajinomoto Co Inc 経口リン酸吸着剤
GB0515353D0 (en) * 2005-07-27 2005-08-31 Psimedica Ltd Food
KR100857411B1 (ko) 2006-07-21 2008-09-08 한올제약주식회사 리파아제 저해제의 경구 투여용 방출조절 약학 제제 및이의 제조 방법
BRPI0905910A2 (pt) 2008-02-11 2015-06-23 Alfonso Garcia-Bennett Método para fabricar materiais mesoporosos, materiais assim produzidos e uso de materiais mesoporosos.
TW200936130A (en) * 2008-02-26 2009-09-01 Lundbeck & Co As H Uses of indane compounds
US20110212055A1 (en) * 2008-03-25 2011-09-01 Commissiong John W Neurodegenerative disorders
JP2010065023A (ja) * 2008-08-14 2010-03-25 Lion Corp 脂溶性ビタミンおよび／または脂溶性色素含有粉体
JP2012506904A (ja) 2008-10-28 2012-03-22 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 難水溶性成分のためのメソ多孔性材料賦形剤
DE102009026686A1 (de) * 2009-06-03 2010-12-23 Airbus France Anordnung zum Blitzschutz einer elektronischen Einheit
EP2547733A1 (en) 2010-03-17 2013-01-23 Nanologica AB Enhanced folic acid fluorescent material, multifluorescent porous compositions of matter and potential applications thereof
ES2768229T3 (es) * 2010-07-06 2020-06-22 Nanologica Ab Método mejorado para diferenciación de células madre in vivo mediante la administración de morfógenos con sílice mesoporosa y principios activos farmacéuticos correspondientes
GB201212866D0 (en) 2012-07-20 2012-09-05 Formac Pharmaceuticals Nv Dry granulates of mesoporous silica powders
HUE055017T2 (hu) 2012-11-06 2021-10-28 Sigrid Therapeutics Ab Pórusos szilíciumdioxid-anyag gyógyászati hatóanyagként vagy élelmiszerekben való alkalmazásra
PL2919903T3 (pl) 2012-11-14 2020-12-14 W.R. Grace & Co. - Conn. Kompozycje zawierające materiał biologicznie aktywny i nieuporządkowany tlenek nieorganiczny
NZ709368A (en) 2012-12-21 2020-01-31 National Health Res Inst Mesoporous silica nanoparticles for oil absorption

Also Published As

Publication number Publication date
US10695294B2 (en) 2020-06-30
US20200390703A1 (en) 2020-12-17
CA3024640A1 (en) 2014-05-15
PH12015501010A1 (en) 2015-07-27
AU2013343565A1 (en) 2015-05-21
ZA201502979B (en) 2024-09-25
HUE055017T2 (hu) 2021-10-28
EP3892285A3 (en) 2021-11-17
IL238538A0 (en) 2015-06-30
CA2890171A1 (en) 2014-05-15
US20150258028A1 (en) 2015-09-17
CY1124471T1 (el) 2022-07-22
JP2015536939A (ja) 2015-12-24
EP2916852A1 (en) 2015-09-16
IL238538B (en) 2019-06-30
BR112015010118A2 (pt) 2017-07-11
EP3892285A2 (en) 2021-10-13
SI2916852T1 (sl) 2021-08-31
JP6752858B2 (ja) 2020-09-09
LT2916852T (lt) 2021-06-25
PT2916852T (pt) 2021-06-15
EP2916852B1 (en) 2021-04-14
AU2013343565B2 (en) 2018-07-26
CN105188720A (zh) 2015-12-23
US12121612B2 (en) 2024-10-22
JP6421124B2 (ja) 2018-11-07
CA3024460A1 (fr) 2018-11-15
DK2916852T3 (en) 2021-05-10
HRP20211036T1 (hr) 2021-10-01
JP2019023222A (ja) 2019-02-14
CN113069467A (zh) 2021-07-06
PL2916852T3 (pl) 2021-11-02
PH12015501010B1 (en) 2023-10-20
ES2878017T3 (es) 2021-11-18
WO2014072363A1 (en) 2014-05-15

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