CA2883344A1 - Low organic extractable depth filter media processed with solvent extraction method - Google Patents
Low organic extractable depth filter media processed with solvent extraction method Download PDFInfo
- Publication number
- CA2883344A1 CA2883344A1 CA2883344A CA2883344A CA2883344A1 CA 2883344 A1 CA2883344 A1 CA 2883344A1 CA 2883344 A CA2883344 A CA 2883344A CA 2883344 A CA2883344 A CA 2883344A CA 2883344 A1 CA2883344 A1 CA 2883344A1
- Authority
- CA
- Canada
- Prior art keywords
- media
- primary clarification
- depth
- flushing
- depth filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 59
- 238000000638 solvent extraction Methods 0.000 title description 2
- 238000005352 clarification Methods 0.000 claims abstract description 98
- 230000008569 process Effects 0.000 claims abstract description 46
- 238000011010 flushing procedure Methods 0.000 claims abstract description 41
- 239000011148 porous material Substances 0.000 claims abstract description 33
- 239000012632 extractable Substances 0.000 claims abstract description 30
- 238000011118 depth filtration Methods 0.000 claims abstract description 25
- 230000001413 cellular effect Effects 0.000 claims abstract description 23
- 239000002245 particle Substances 0.000 claims abstract description 19
- 238000009826 distribution Methods 0.000 claims abstract description 6
- 229920000642 polymer Polymers 0.000 claims description 43
- -1 polypropylene Polymers 0.000 claims description 36
- 239000004743 Polypropylene Substances 0.000 claims description 29
- 229920001155 polypropylene Polymers 0.000 claims description 29
- 239000001913 cellulose Substances 0.000 claims description 24
- 229920002678 cellulose Polymers 0.000 claims description 24
- 239000000835 fiber Substances 0.000 claims description 24
- 239000002904 solvent Substances 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 8
- 239000003960 organic solvent Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 5
- 239000004215 Carbon black (E152) Substances 0.000 claims description 4
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims description 4
- 229930195733 hydrocarbon Natural products 0.000 claims description 4
- 150000002430 hydrocarbons Chemical class 0.000 claims description 4
- FRCHKSNAZZFGCA-UHFFFAOYSA-N 1,1-dichloro-1-fluoroethane Chemical compound CC(F)(Cl)Cl FRCHKSNAZZFGCA-UHFFFAOYSA-N 0.000 claims description 3
- 239000004677 Nylon Substances 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 2
- 229940126587 biotherapeutics Drugs 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 229920001778 nylon Polymers 0.000 claims 2
- 229920000768 polyamine Polymers 0.000 claims 2
- 229920000728 polyester Polymers 0.000 claims 2
- 229920000573 polyethylene Polymers 0.000 claims 2
- 238000004113 cell culture Methods 0.000 abstract description 40
- 238000005119 centrifugation Methods 0.000 abstract description 16
- 238000001471 micro-filtration Methods 0.000 abstract description 12
- 210000004962 mammalian cell Anatomy 0.000 abstract description 7
- 239000012530 fluid Substances 0.000 abstract description 2
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 49
- 102000004169 proteins and genes Human genes 0.000 description 42
- 108090000623 proteins and genes Proteins 0.000 description 42
- 210000004027 cell Anatomy 0.000 description 28
- 239000000463 material Substances 0.000 description 23
- 102000004196 processed proteins & peptides Human genes 0.000 description 22
- 108090000765 processed proteins & peptides Proteins 0.000 description 22
- 229920001184 polypeptide Polymers 0.000 description 21
- 238000001914 filtration Methods 0.000 description 20
- 239000012535 impurity Substances 0.000 description 19
- 239000000203 mixture Substances 0.000 description 16
- 239000005909 Kieselgur Substances 0.000 description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 238000003306 harvesting Methods 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 239000007787 solid Substances 0.000 description 11
- 108091008038 CHOP Proteins 0.000 description 9
- 102100021246 DDIT3 upstream open reading frame protein Human genes 0.000 description 9
- 238000000746 purification Methods 0.000 description 9
- 238000010306 acid treatment Methods 0.000 description 8
- 239000000654 additive Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000002244 precipitate Substances 0.000 description 8
- 239000011347 resin Substances 0.000 description 8
- 229920005989 resin Polymers 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 7
- 239000012528 membrane Substances 0.000 description 7
- 235000010633 broth Nutrition 0.000 description 6
- 239000013315 hypercross-linked polymer Substances 0.000 description 6
- 230000014759 maintenance of location Effects 0.000 description 6
- 239000002356 single layer Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000002028 Biomass Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000007790 solid phase Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 239000006143 cell culture medium Substances 0.000 description 3
- 238000011210 chromatographic step Methods 0.000 description 3
- 239000012501 chromatography medium Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000012864 cross contamination Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000005189 flocculation Methods 0.000 description 3
- 230000016615 flocculation Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 101150064725 LIM2 gene Proteins 0.000 description 2
- 101100454869 Rattus norvegicus Lhx5 gene Proteins 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
- 239000012539 chromatography resin Substances 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 239000008394 flocculating agent Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000009285 membrane fouling Methods 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000010200 validation analysis Methods 0.000 description 2
- CYNYIHKIEHGYOZ-UHFFFAOYSA-N 1-bromopropane Chemical compound CCCBr CYNYIHKIEHGYOZ-UHFFFAOYSA-N 0.000 description 1
- MYLBTCQBKAKUTJ-UHFFFAOYSA-N 7-methyl-6,8-bis(methylsulfanyl)pyrrolo[1,2-a]pyrazine Chemical compound C1=CN=CC2=C(SC)C(C)=C(SC)N21 MYLBTCQBKAKUTJ-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 101100542977 Arabidopsis thaliana PIPC gene Proteins 0.000 description 1
- 206010003402 Arthropod sting Diseases 0.000 description 1
- 101100494164 Brassica napus BP4C gene Proteins 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 101100511184 Dictyostelium discoideum limB gene Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 239000012901 Milli-Q water Substances 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003011 anion exchange membrane Substances 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 238000010364 biochemical engineering Methods 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012527 feed solution Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000003311 flocculating effect Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000012561 harvest cell culture fluid Substances 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000036619 pore blockages Effects 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Water Supply & Treatment (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Filtering Materials (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656263P | 2012-06-06 | 2012-06-06 | |
| US61/656,263 | 2012-06-06 | ||
| US201261664999P | 2012-06-27 | 2012-06-27 | |
| US61/664,999 | 2012-06-27 | ||
| PCT/US2013/044550 WO2013184937A1 (en) | 2012-06-06 | 2013-06-06 | Low organic extractable depth filter media processed with solvent extraction method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2883344A1 true CA2883344A1 (en) | 2013-12-12 |
Family
ID=49712640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2883344A Abandoned CA2883344A1 (en) | 2012-06-06 | 2013-06-06 | Low organic extractable depth filter media processed with solvent extraction method |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20150133643A1 (enExample) |
| EP (1) | EP2859084A4 (enExample) |
| JP (1) | JP2015520026A (enExample) |
| CN (1) | CN104334712A (enExample) |
| CA (1) | CA2883344A1 (enExample) |
| IN (1) | IN2014DN10011A (enExample) |
| SG (1) | SG11201407525VA (enExample) |
| WO (1) | WO2013184937A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140004231A (ko) | 2011-07-08 | 2014-01-10 | 이엠디 밀리포어 코포레이션 | 일회용 생명공학적 공정용의 개선된 심층 필터 |
| US11660555B2 (en) | 2013-08-30 | 2023-05-30 | Emd Millipore Corporation | High capacity composite depth filter media with low extractables |
| US10564087B2 (en) * | 2014-09-12 | 2020-02-18 | Celularity, Inc. | Methods for quantifying particulates in cell culture |
| WO2016205204A1 (en) * | 2015-06-15 | 2016-12-22 | White Dog Labs, Inc. | Method for producing one or more oil-soluble bioproducts |
| CN108593755B (zh) * | 2018-04-28 | 2025-05-09 | 清华大学 | 一种细胞外泌物质采样与原位检测方法及装置 |
| CN110585773A (zh) * | 2018-06-13 | 2019-12-20 | 杭州科百特过滤器材有限公司 | 一种过滤纸板及其制备方法 |
| CA3107770C (en) | 2018-08-16 | 2023-09-05 | Emd Millipore Corporation | Closed bioprocessing device |
| EP4297884A4 (en) * | 2021-02-26 | 2025-01-15 | Solventum Intellectual Properties Company | CHARGED DEPTH FILTER FOR THERAPEUTIC BIOTECHNOLOGICAL MANUFACTURING PROCESS |
| CN115011445A (zh) * | 2022-06-08 | 2022-09-06 | 广州汉方医学生物科技有限公司 | 胞外多糖发酵提取装置及发酵提取方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0780262A (ja) * | 1993-09-14 | 1995-03-28 | Toray Ind Inc | 逆浸透膜および逆浸透膜分離素子の処理方法 |
| MX9602812A (es) * | 1994-01-18 | 1997-06-28 | Du Pont | Sales de amonio polimericas, reticuladas. |
| JP2867223B2 (ja) * | 1995-03-01 | 1999-03-08 | 株式会社ソルベックス | オゾン低分解性で安全な布帛用汚点除去剤 |
| EP0880988B1 (en) * | 1996-09-25 | 2004-07-21 | Chisso Corporation | High-precision filter |
| JP4107720B2 (ja) * | 1998-07-07 | 2008-06-25 | スリーエム カンパニー | 半導体製造装置における汚染物の洗浄方法 |
| KR100501817B1 (ko) * | 1998-07-21 | 2005-07-20 | 몬산토 테크놀로지 엘엘씨 | 음이온 폴리머성 응집제들을 사용한 단백질 침전물 현탁액의 청징화 방법 |
| JP2004129941A (ja) * | 2002-10-11 | 2004-04-30 | Asahi Kasei Corp | 白血球選択除去フィルター |
| US7125434B2 (en) * | 2002-12-19 | 2006-10-24 | Millipore Corporation | Deep gradient-density filter device |
| US20050279695A1 (en) * | 2004-06-17 | 2005-12-22 | Millipore Corporation | Disposable integral filter unit |
| CA2595594C (en) * | 2005-01-31 | 2012-05-01 | Merck & Co., Inc. | Upstream and a downstream purification process for large scale production of plasmid dna |
| US20060205080A1 (en) * | 2005-03-01 | 2006-09-14 | David Frey | Formulations for therapeutic viruses having enhanced storage stability |
| CN101163794A (zh) * | 2005-03-01 | 2008-04-16 | 细胞基因体系公司 | 具有提高的贮存稳定性的治疗用病毒制剂 |
| JP5371175B2 (ja) * | 2005-03-08 | 2013-12-18 | ダイキン工業株式会社 | 電子・電気部品用防湿コーティング組成物および防湿コーティング膜の形成方法 |
| JP4800643B2 (ja) * | 2005-03-16 | 2011-10-26 | ダイワボウホールディングス株式会社 | 筒状フィルターおよびその製造方法 |
| US7531632B2 (en) * | 2006-02-16 | 2009-05-12 | Gtc Biotherapeutics, Inc. | Clarification of transgenic milk using depth filtration |
| US8569464B2 (en) * | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| TWI610936B (zh) * | 2008-10-20 | 2018-01-11 | 艾伯維有限公司 | 使用蛋白質ａ親和性層析進行抗體之分離及純化 |
| EP2446077B1 (en) * | 2009-06-23 | 2016-05-18 | 3M Innovative Properties Company | Functionalized nonwoven article |
| JP2011072859A (ja) * | 2009-09-29 | 2011-04-14 | Kurita Water Ind Ltd | ろ過膜の洗浄方法および洗浄剤 |
| DK2571903T3 (da) * | 2010-05-17 | 2019-11-04 | Emd Millipore Corp | Polymerer, der reagerer på stimuli, til oprensning af biomolekyler |
| US20130273607A1 (en) * | 2010-10-20 | 2013-10-17 | Medimmune, Llc | Methods for processing inclusion bodies |
| KR20140004231A (ko) * | 2011-07-08 | 2014-01-10 | 이엠디 밀리포어 코포레이션 | 일회용 생명공학적 공정용의 개선된 심층 필터 |
-
2013
- 2013-06-06 IN IN10011DEN2014 patent/IN2014DN10011A/en unknown
- 2013-06-06 JP JP2015516218A patent/JP2015520026A/ja active Pending
- 2013-06-06 CA CA2883344A patent/CA2883344A1/en not_active Abandoned
- 2013-06-06 EP EP13801241.4A patent/EP2859084A4/en not_active Withdrawn
- 2013-06-06 CN CN201380028257.1A patent/CN104334712A/zh active Pending
- 2013-06-06 US US14/400,392 patent/US20150133643A1/en not_active Abandoned
- 2013-06-06 SG SG11201407525VA patent/SG11201407525VA/en unknown
- 2013-06-06 WO PCT/US2013/044550 patent/WO2013184937A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2859084A4 (en) | 2015-12-30 |
| EP2859084A1 (en) | 2015-04-15 |
| WO2013184937A1 (en) | 2013-12-12 |
| SG11201407525VA (en) | 2014-12-30 |
| JP2015520026A (ja) | 2015-07-16 |
| US20150133643A1 (en) | 2015-05-14 |
| IN2014DN10011A (enExample) | 2015-08-14 |
| CN104334712A (zh) | 2015-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20170606 |