IN2014DN10011A - - Google Patents
Info
- Publication number
- IN2014DN10011A IN2014DN10011A IN10011DEN2014A IN2014DN10011A IN 2014DN10011 A IN2014DN10011 A IN 2014DN10011A IN 10011DEN2014 A IN10011DEN2014 A IN 10011DEN2014A IN 2014DN10011 A IN2014DN10011 A IN 2014DN10011A
- Authority
- IN
- India
- Prior art keywords
- primary clarification
- media
- feeds
- flocculated
- depth filtration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Abstract
Provided is a primary clarification depth filtration process of cell- culture feeds , including chemically treated flocculated feeds, containing target biomolecules of interest such as rrAbs, mammalian cell cultures , or bacterial cell cultures , utilizing a primary clarification depth filtration device containing a media with significantly lower flushing requirements ,resulting in lower levels of organic extractables released after media flushing, and increased throughput for the pre- treated feed streams , without the use of a primary clarification centrifugation step or primary clarification tangential flow microfiltration step. The primary clarification depth filtration device used in the primary clarification of fluid cell culture feeds ,including chemically treated flocculated feeds containing flocculated cellular debris and/or colloidal particulates having a particle size distribution of about 0.5 µm to 200 um , contains a porous depth filter media having porous layers of varying pore ratings , and achieves the desired level , of total organic extractables (1- 3 ppm) measured in the feed filtered through the media with , significantly lower flushing requirements. Kits and methods of using and making the same are also provided.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656263P | 2012-06-06 | 2012-06-06 | |
| US201261664999P | 2012-06-27 | 2012-06-27 | |
| PCT/US2013/044550 WO2013184937A1 (en) | 2012-06-06 | 2013-06-06 | Low organic extractable depth filter media processed with solvent extraction method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN10011A true IN2014DN10011A (en) | 2015-08-14 |
Family
ID=49712640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN10011DEN2014 IN2014DN10011A (en) | 2012-06-06 | 2013-06-06 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20150133643A1 (en) |
| EP (1) | EP2859084A4 (en) |
| JP (1) | JP2015520026A (en) |
| CN (1) | CN104334712A (en) |
| CA (1) | CA2883344A1 (en) |
| IN (1) | IN2014DN10011A (en) |
| SG (1) | SG11201407525VA (en) |
| WO (1) | WO2013184937A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6027104B2 (en) | 2011-07-08 | 2016-11-16 | イー・エム・デイー・ミリポア・コーポレイシヨン | Improved depth filter for disposable biotechnology methods |
| KR20160013173A (en) | 2013-08-30 | 2016-02-03 | 이엠디 밀리포어 코포레이션 | High capacity composite depth filter media with low extractables |
| US10564087B2 (en) * | 2014-09-12 | 2020-02-18 | Celularity, Inc. | Methods for quantifying particulates in cell culture |
| EP3307701A4 (en) * | 2015-06-15 | 2019-01-30 | White Dog Labs, Inc. | Method for producing one or more oil-soluble bioproducts |
| CN108593755A (en) * | 2018-04-28 | 2018-09-28 | 清华大学 | A kind of extracellular secretion matter sampling and in-situ detection method and device |
| CN110585773A (en) * | 2018-06-13 | 2019-12-20 | 杭州科百特过滤器材有限公司 | Filtering paperboard and preparation method thereof |
| WO2022180572A1 (en) * | 2021-02-26 | 2022-09-01 | 3M Innovative Properties Company | Charged depth filter for therapeutic biotechnology manufacturing process |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0780262A (en) * | 1993-09-14 | 1995-03-28 | Toray Ind Inc | Treatment of reverse osmosis membrane and reverse osmosis membrane separation element |
| MX9602812A (en) * | 1994-01-18 | 1997-06-28 | Du Pont | Crosslinked polymeric ammonium salts. |
| JP2867223B2 (en) * | 1995-03-01 | 1999-03-08 | 株式会社ソルベックス | Low ozone decomposable and safe stain remover for fabrics |
| WO1998013123A1 (en) * | 1996-09-25 | 1998-04-02 | Chisso Corporation | High-precision filter |
| JP4107720B2 (en) * | 1998-07-07 | 2008-06-25 | スリーエム カンパニー | Method for cleaning contaminants in semiconductor manufacturing equipment |
| CA2338319A1 (en) * | 1998-07-21 | 2000-02-03 | Monsanto Company | Clarification of protein precipitate suspensions using anionic polymeric flocculants |
| JP2004129941A (en) * | 2002-10-11 | 2004-04-30 | Asahi Kasei Corp | Leukocyte selective removal filter |
| US7125434B2 (en) * | 2002-12-19 | 2006-10-24 | Millipore Corporation | Deep gradient-density filter device |
| US20050279695A1 (en) * | 2004-06-17 | 2005-12-22 | Millipore Corporation | Disposable integral filter unit |
| US7767399B2 (en) * | 2005-01-31 | 2010-08-03 | Merck & Co., Inc. | Purification process for plasmid DNA |
| US20060205080A1 (en) * | 2005-03-01 | 2006-09-14 | David Frey | Formulations for therapeutic viruses having enhanced storage stability |
| CN101163794A (en) * | 2005-03-01 | 2008-04-16 | 细胞基因体系公司 | Formulations for therapeutic viruses having enhanced storage stability |
| JP5371175B2 (en) * | 2005-03-08 | 2013-12-18 | ダイキン工業株式会社 | Moisture-proof coating composition for electronic and electrical parts and method for forming moisture-proof coating film |
| JP4800643B2 (en) * | 2005-03-16 | 2011-10-26 | ダイワボウホールディングス株式会社 | Cylindrical filter and manufacturing method thereof |
| US7531632B2 (en) * | 2006-02-16 | 2009-05-12 | Gtc Biotherapeutics, Inc. | Clarification of transgenic milk using depth filtration |
| US8569464B2 (en) * | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| CN105111309A (en) * | 2008-10-20 | 2015-12-02 | Abbvie公司 | Isolation and purification of antibodies using protein an appinity chromatography |
| EP2446077B1 (en) * | 2009-06-23 | 2016-05-18 | 3M Innovative Properties Company | Functionalized nonwoven article |
| JP2011072859A (en) * | 2009-09-29 | 2011-04-14 | Kurita Water Ind Ltd | Method of cleaning filter membrane and cleaning agent |
| CN107312062B (en) * | 2010-05-17 | 2021-03-16 | Emd密理博公司 | Stimulus responsive polymers for purification of biomolecules |
| AU2011317021B2 (en) * | 2010-10-20 | 2015-07-09 | Medimmune, Llc | Methods for processing inclusion bodies |
| JP6027104B2 (en) * | 2011-07-08 | 2016-11-16 | イー・エム・デイー・ミリポア・コーポレイシヨン | Improved depth filter for disposable biotechnology methods |
-
2013
- 2013-06-06 US US14/400,392 patent/US20150133643A1/en not_active Abandoned
- 2013-06-06 WO PCT/US2013/044550 patent/WO2013184937A1/en active Application Filing
- 2013-06-06 CN CN201380028257.1A patent/CN104334712A/en active Pending
- 2013-06-06 EP EP13801241.4A patent/EP2859084A4/en not_active Withdrawn
- 2013-06-06 CA CA2883344A patent/CA2883344A1/en not_active Abandoned
- 2013-06-06 SG SG11201407525VA patent/SG11201407525VA/en unknown
- 2013-06-06 IN IN10011DEN2014 patent/IN2014DN10011A/en unknown
- 2013-06-06 JP JP2015516218A patent/JP2015520026A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015520026A (en) | 2015-07-16 |
| EP2859084A1 (en) | 2015-04-15 |
| CA2883344A1 (en) | 2013-12-12 |
| SG11201407525VA (en) | 2014-12-30 |
| EP2859084A4 (en) | 2015-12-30 |
| WO2013184937A1 (en) | 2013-12-12 |
| US20150133643A1 (en) | 2015-05-14 |
| CN104334712A (en) | 2015-02-04 |
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