CA2882276C - Recombinant microorganisms expressing a stereospecific diol dehydratase enzyme - Google Patents
Recombinant microorganisms expressing a stereospecific diol dehydratase enzyme Download PDFInfo
- Publication number
- CA2882276C CA2882276C CA2882276A CA2882276A CA2882276C CA 2882276 C CA2882276 C CA 2882276C CA 2882276 A CA2882276 A CA 2882276A CA 2882276 A CA2882276 A CA 2882276A CA 2882276 C CA2882276 C CA 2882276C
- Authority
- CA
- Canada
- Prior art keywords
- propan
- microorganism
- diol
- clostridium
- propane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01028—Propanediol dehydratase (4.2.1.28)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261694104P | 2012-08-28 | 2012-08-28 | |
| US61/694,104 | 2012-08-28 | ||
| US201261720224P | 2012-10-30 | 2012-10-30 | |
| US61/720,224 | 2012-10-30 | ||
| PCT/US2013/057103 WO2014036152A1 (en) | 2012-08-28 | 2013-08-28 | Recombinant microorganisms and uses therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| CA2882276A1 CA2882276A1 (en) | 2014-03-06 |
| CA2882276E CA2882276E (en) | 2014-03-06 |
| CA2882276C true CA2882276C (en) | 2016-11-01 |
Family
ID=50184309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2882276A Active CA2882276C (en) | 2012-08-28 | 2013-08-28 | Recombinant microorganisms expressing a stereospecific diol dehydratase enzyme |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9284564B2 (enExample) |
| EP (1) | EP2890778B1 (enExample) |
| JP (1) | JP6302471B2 (enExample) |
| KR (1) | KR102121888B1 (enExample) |
| CN (1) | CN105051179B (enExample) |
| CA (1) | CA2882276C (enExample) |
| IN (1) | IN2015DN01365A (enExample) |
| SG (1) | SG11201501254RA (enExample) |
| WO (1) | WO2014036152A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130323820A1 (en) | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| EP3099779B1 (en) | 2014-01-28 | 2020-09-02 | LanzaTech New Zealand Limited | Method of producing a recombinant microorganism |
| TWI689592B (zh) | 2014-10-22 | 2020-04-01 | 紐西蘭商藍瑟科技紐西蘭有限公司 | 多段生物反應器方法 |
| JP6905518B2 (ja) | 2015-10-13 | 2021-07-21 | ランザテク・ニュージーランド・リミテッド | エネルギー発生発酵経路を含む遺伝子操作細菌 |
| US10358661B2 (en) | 2015-12-28 | 2019-07-23 | Lanzatech New Zealand Limited | Microorganism with modified hydrogenase activity |
| KR20230044031A (ko) | 2016-05-14 | 2023-03-31 | 란자테크, 인크. | 알데히드:페레독신 옥시도리덕타제 활성이 변경된 미생물 및 관련 방법 |
| EP3498841A4 (en) * | 2016-10-13 | 2020-04-08 | Sekisui Chemical Co., Ltd. | Obligately anaerobic acetic acid-producing microorganism, and recombinant microorganism |
| CN117551705A (zh) | 2017-09-08 | 2024-02-13 | 朗泽科技有限公司 | 用于使用富氢气的含有c1的底物生产代谢物的方法和系统 |
| CA3079761C (en) | 2017-12-19 | 2023-09-19 | Lanzatech, Inc. | Microorganisms and methods for the biological production of ethylene glycol |
| CA3090411A1 (en) | 2018-02-12 | 2019-08-15 | Lanzatech, Inc. | A process for improving carbon conversion efficiency |
| MY204224A (en) | 2018-04-20 | 2024-08-16 | Lanzatech Inc | Intermittent electrolysis streams |
| KR102173766B1 (ko) * | 2018-11-05 | 2020-11-04 | 서강대학교산학협력단 | 메틸영양세균을 이용한 1,2-프로필렌글라이콜 생산용 조성물 및 그의 생산 방법 |
| CA3120151C (en) | 2018-11-19 | 2024-04-30 | Lanzatech, Inc. | Integration of fermentation and gasification |
| US11091415B2 (en) | 2019-02-08 | 2021-08-17 | Lanzatech, Inc. | Process for recovering close boiling products |
| CN113614240B (zh) | 2019-03-20 | 2024-12-13 | 环球生物能源公司 | 用于从乙酰-CoA生产异丁烯的改进手段和方法 |
| KR20240158377A (ko) | 2019-07-11 | 2024-11-04 | 란자테크, 인크. | 가스 이용률을 최적화하는 방법 |
| KR102346757B1 (ko) * | 2019-09-30 | 2021-12-31 | 서강대학교산학협력단 | 1,2-프로필렌글라이콜 생산성이 증강된 메틸영양세균 및 이를 이용한 1,2-프로필렌글라이콜 생산방법 |
| US11932818B2 (en) | 2020-03-16 | 2024-03-19 | Lanzatech, Inc. | Tail gas of gas fermentation to dry gasification feedstock |
| AU2021237368B2 (en) | 2020-03-18 | 2025-05-08 | Lanzatech, Inc. | Fermentative production of 2-phenylethanol from gaseous substrates |
| CN114144513A (zh) | 2020-04-29 | 2022-03-04 | 朗泽科技有限公司 | 从气态底物发酵生产β-酮己二酸盐 |
| JP2023520257A (ja) | 2020-06-06 | 2023-05-16 | ランザテク，インコーポレイテッド | アセトラクテートデカルボキシラーゼ遺伝子座位でのノックインを有する微生物 |
| AU2022218205A1 (en) | 2021-02-08 | 2023-05-25 | Lanzatech, Inc. | Recombinant microorganisms and uses therefor |
| WO2022217282A1 (en) | 2021-04-09 | 2022-10-13 | Lanzatech, Inc. | Process and apparatus for providing a feedstock |
| US12241105B2 (en) | 2021-07-20 | 2025-03-04 | Lanzatech, Inc. | Recombinant microorganisms and uses therefor |
| CN117693588A (zh) * | 2021-08-06 | 2024-03-12 | 朗泽科技有限公司 | 用于改进乙二醇的生物产生的微生物和方法 |
| TW202307202A (zh) | 2021-08-06 | 2023-02-16 | 美商朗澤科技有限公司 | 用於改良乙二醇之生物產生的微生物及方法 |
| US12091648B2 (en) | 2021-11-03 | 2024-09-17 | Lanzatech, Inc. | System and method for generating bubbles in a vessel |
| US12280331B2 (en) | 2022-04-29 | 2025-04-22 | Lanzatech, Inc. | Low residence time gas separator |
| US12077800B2 (en) | 2022-06-16 | 2024-09-03 | Lanzatech, Inc. | Liquid distributor system and process of liquid distribution |
| WO2023250382A1 (en) | 2022-06-21 | 2023-12-28 | Lanzatech, Inc. | Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from c1-substrates |
| AU2023289395A1 (en) | 2022-06-21 | 2025-01-09 | Lanzatech, Inc. | Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from c1-substrates |
| WO2024036187A1 (en) | 2022-08-10 | 2024-02-15 | Lanzatech, Inc. | Carbon sequestration in soils with production of chemical products |
| WO2024253882A1 (en) | 2023-06-05 | 2024-12-12 | Lanzatech, Inc. | Integrated gas fermentation |
| US12359224B2 (en) | 2023-06-05 | 2025-07-15 | Lanzatech, Inc. | Integrated gas fermentation and carbon black processes |
| CN117887619A (zh) * | 2023-12-27 | 2024-04-16 | 中国科学技术大学 | 一种产己酸的复合微生物菌剂及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| ID21487A (id) * | 1996-11-13 | 1999-06-17 | Du Pont | Metoda pembuatan 1,3 - propandiol dengan organisme rekombinan |
| UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
| JP4883872B2 (ja) | 2000-07-25 | 2012-02-22 | エモース・フアンデーシヨン・インコーポレーテツド | 微生物発酵によるエタノール生産を向上させる方法 |
| US7628161B1 (en) * | 2004-10-22 | 2009-12-08 | Valentino Janna Lo Sauro | Hair-cutting and styling device and method of use |
| US8962298B2 (en) * | 2006-05-02 | 2015-02-24 | Butamax Advanced Biofuels Llc | Recombinant host cell comprising a diol dehydratase |
| US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
| JP2010539988A (ja) | 2007-10-04 | 2010-12-24 | ビオ アルチテクトウレ ラブ インコーポレイテッド | 生物燃料製品 |
| KR101375029B1 (ko) | 2007-11-13 | 2014-03-14 | 란자테크 뉴질랜드 리미티드 | 신규 세균 및 이의 이용 방법 |
| CN102666862A (zh) * | 2009-08-21 | 2012-09-12 | 马斯科马公司 | 在联合生物加工生物体中生产丙醇、醇和多元醇 |
| EP2295593A1 (en) | 2009-09-15 | 2011-03-16 | Philippe Marliere | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA |
| US8143037B2 (en) | 2010-03-19 | 2012-03-27 | Coskata, Inc. | Ethanologenic Clostridium species, Clostridium coskatii |
| CN103415618A (zh) * | 2010-08-19 | 2013-11-27 | 新西兰郎泽科技公司 | 使用对含一氧化碳的底物的微生物发酵来生产化学物质的方法 |
| US20110236941A1 (en) | 2010-10-22 | 2011-09-29 | Lanzatech New Zealand Limited | Recombinant microorganism and methods of production thereof |
| US9410130B2 (en) | 2011-02-25 | 2016-08-09 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| US9365868B2 (en) | 2011-02-25 | 2016-06-14 | Lanzatech New Zealand Limited | Fermentation process for producing isopropanol using a recombinant microorganism |
| CN104919037A (zh) | 2012-06-08 | 2015-09-16 | 朗泽科技新西兰有限公司 | 重组微生物和其用途 |
-
2013
- 2013-08-28 CA CA2882276A patent/CA2882276C/en active Active
- 2013-08-28 IN IN1365DEN2015 patent/IN2015DN01365A/en unknown
- 2013-08-28 KR KR1020157004952A patent/KR102121888B1/ko active Active
- 2013-08-28 JP JP2015529999A patent/JP6302471B2/ja active Active
- 2013-08-28 US US14/011,872 patent/US9284564B2/en active Active
- 2013-08-28 SG SG11201501254RA patent/SG11201501254RA/en unknown
- 2013-08-28 CN CN201380045791.3A patent/CN105051179B/zh not_active Expired - Fee Related
- 2013-08-28 EP EP13833516.1A patent/EP2890778B1/en not_active Not-in-force
- 2013-08-28 WO PCT/US2013/057103 patent/WO2014036152A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014036152A1 (en) | 2014-03-06 |
| CN105051179A (zh) | 2015-11-11 |
| CA2882276A1 (en) | 2014-03-06 |
| IN2015DN01365A (enExample) | 2015-07-03 |
| KR20150045447A (ko) | 2015-04-28 |
| US9284564B2 (en) | 2016-03-15 |
| CN105051179B (zh) | 2018-06-15 |
| KR102121888B1 (ko) | 2020-06-12 |
| EP2890778A1 (en) | 2015-07-08 |
| JP6302471B2 (ja) | 2018-03-28 |
| EP2890778B1 (en) | 2019-05-01 |
| CA2882276E (en) | 2014-03-06 |
| US20140065698A1 (en) | 2014-03-06 |
| SG11201501254RA (en) | 2015-03-30 |
| JP2015526105A (ja) | 2015-09-10 |
| EP2890778A4 (en) | 2016-03-30 |
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