CA2875733C - Beta-hairpin peptidomimetics - Google Patents

Beta-hairpin peptidomimetics Download PDF

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Publication number
CA2875733C
CA2875733C CA2875733A CA2875733A CA2875733C CA 2875733 C CA2875733 C CA 2875733C CA 2875733 A CA2875733 A CA 2875733A CA 2875733 A CA2875733 A CA 2875733A CA 2875733 C CA2875733 C CA 2875733C
Authority
CA
Canada
Prior art keywords
activity
ipr
acid
cys4
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2875733A
Other languages
English (en)
French (fr)
Other versions
CA2875733A1 (en
Inventor
Frank Otto Gombert
Daniel Obrecht
Alexander Lederer
Johann Zimmermann
Christian Oefner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spexis AG
Original Assignee
Polyphor AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor AG filed Critical Polyphor AG
Publication of CA2875733A1 publication Critical patent/CA2875733A1/en
Application granted granted Critical
Publication of CA2875733C publication Critical patent/CA2875733C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2875733A 2012-06-06 2012-06-06 Beta-hairpin peptidomimetics Active CA2875733C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2012/060766 WO2013182240A1 (en) 2012-06-06 2012-06-06 Beta-hairpin peptidomimetics

Publications (2)

Publication Number Publication Date
CA2875733A1 CA2875733A1 (en) 2013-12-12
CA2875733C true CA2875733C (en) 2019-09-10

Family

ID=46208596

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2875733A Active CA2875733C (en) 2012-06-06 2012-06-06 Beta-hairpin peptidomimetics

Country Status (12)

Country Link
US (2) US9617308B2 (show.php)
EP (1) EP2859012B1 (show.php)
JP (1) JP6047231B2 (show.php)
CN (1) CN104603145B (show.php)
AU (1) AU2012381808B2 (show.php)
CA (1) CA2875733C (show.php)
ES (1) ES2647076T3 (show.php)
IL (1) IL235946B (show.php)
IN (1) IN2014KN02752A (show.php)
MX (1) MX355396B (show.php)
SG (1) SG11201407837WA (show.php)
WO (1) WO2013182240A1 (show.php)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5140686B2 (ja) 2007-02-28 2013-02-06 ポリファー リミテッド テンプレート固定ペプチド模倣薬
IN2014KN02752A (show.php) * 2012-06-06 2015-05-08 Polyphor Ag
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
BR112017003718B1 (pt) 2014-09-11 2023-04-11 Bristol-Myers Squibb Company Inibidores macrocíclicos das interações de proteína/proteína de pd- 1/pd-l1 e cd80(b7-1)/pd-l1
US9732119B2 (en) 2014-10-10 2017-08-15 Bristol-Myers Squibb Company Immunomodulators
US9856292B2 (en) 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
US9861680B2 (en) 2014-12-18 2018-01-09 Bristol-Myers Squibb Company Immunomodulators
US9944678B2 (en) 2014-12-19 2018-04-17 Bristol-Myers Squibb Company Immunomodulators
US20160222060A1 (en) 2015-02-04 2016-08-04 Bristol-Myers Squibb Company Immunomodulators
US9809625B2 (en) 2015-03-18 2017-11-07 Bristol-Myers Squibb Company Immunomodulators
US10143746B2 (en) 2016-03-04 2018-12-04 Bristol-Myers Squibb Company Immunomodulators
US10358463B2 (en) 2016-04-05 2019-07-23 Bristol-Myers Squibb Company Immunomodulators
SMT202100238T1 (it) 2016-05-19 2021-05-07 Bristol Myers Squibb Co Immunomodulatori per l'indagine per immagini mediante pet
CA3032885C (en) * 2016-09-06 2023-06-20 Mainline Biosciences Cxcr4 antagonists and methods of use
ES2910832T3 (es) 2016-11-07 2022-05-13 Bristol Myers Squibb Co Inmunomoduladores
JP7206222B2 (ja) 2017-06-23 2023-01-17 ブリストル－マイヤーズ スクイブ カンパニー Ｐｄ－１のアンタゴニストとして作用する免疫調節剤
KR20230145543A (ko) * 2017-09-05 2023-10-17 메인라인 바이오사이언스 고친화성 cxcr4 선택적 결합 콘쥬게이트 및 그 사용 방법
US11123437B2 (en) 2017-09-05 2021-09-21 Mainline Biosciences, Inc. Selective CXCR4 binding peptide conjugate and methods for making and using the same
WO2019070643A1 (en) 2017-10-03 2019-04-11 Bristol-Myers Squibb Company IMMUNOMODULATORS
ES2967135T3 (es) 2020-01-06 2024-04-26 Bristol Myers Squibb Co Inmunomoduladores
CN115003684A (zh) * 2020-01-26 2022-09-02 主线生物科学有限公司 同位素标记的选择性cxcr4结合肽偶联物及其制备和使用方法
EP4126902B1 (en) 2020-03-30 2023-12-06 Bristol-Myers Squibb Company Immunomodulators
JP2023549921A (ja) 2020-11-19 2023-11-29 スペクシス アーゲー がんを治療するためのペプチドｃｘｃｒ４阻害剤およびタキサンを含む医薬組み合わせ
WO2022184320A2 (en) 2021-03-03 2022-09-09 Spexis Ag Medical use of cyclic peptides
WO2023285681A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2023285677A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2025068348A1 (en) 2023-09-27 2025-04-03 Spexis Ag Pharmaceutical combination of cxcr4 and pd-1 inhibitors for treating cancer
WO2025068346A1 (en) 2023-09-27 2025-04-03 Spexis Ag Pharmaceutical combination of cxcr4, pd-1 and fak inhibitors for treating cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212288A (en) * 1990-02-20 1993-05-18 Syntex (U.S.A.) Inc. Temporary minimal protection synthesis of serine-containing polypeptides
AU2003232253A1 (en) * 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
JP5308829B2 (ja) * 2006-02-27 2013-10-09 テクニッシュ ユニべルシタット ミュンヘン 癌の画像化および処置
JP5140686B2 (ja) * 2007-02-28 2013-02-06 ポリファー リミテッド テンプレート固定ペプチド模倣薬
US8865656B2 (en) * 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
US8716242B2 (en) * 2009-12-04 2014-05-06 Polyphor Ag β-hairpin peptidomimetics
CN103703018B (zh) * 2011-06-07 2016-10-26 波利弗尔股份公司 作为CXC4拮抗剂的β-发夹肽模拟物
IN2014KN02752A (show.php) * 2012-06-06 2015-05-08 Polyphor Ag

Also Published As

Publication number Publication date
JP6047231B2 (ja) 2016-12-21
SG11201407837WA (en) 2014-12-30
NZ702470A (en) 2016-12-23
WO2013182240A1 (en) 2013-12-12
HK1207867A1 (en) 2016-02-12
US9617308B2 (en) 2017-04-11
US20170165319A1 (en) 2017-06-15
CN104603145B (zh) 2018-05-18
ES2647076T3 (es) 2017-12-19
AU2012381808B2 (en) 2017-04-27
IN2014KN02752A (show.php) 2015-05-08
MX2014014840A (es) 2015-02-12
AU2012381808A1 (en) 2015-01-22
MX355396B (es) 2018-04-18
CA2875733A1 (en) 2013-12-12
US10363284B2 (en) 2019-07-30
US20150218219A1 (en) 2015-08-06
IL235946B (en) 2019-06-30
EP2859012A1 (en) 2015-04-15
CN104603145A (zh) 2015-05-06
EP2859012B1 (en) 2017-08-09
JP2015521204A (ja) 2015-07-27
IL235946A0 (en) 2015-01-29

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Effective date: 20170323