CA2871585A1 - Novel composition for extracorporeal reduction of beta-amyloids and process for producing thereof - Google Patents

Novel composition for extracorporeal reduction of beta-amyloids and process for producing thereof Download PDF

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Publication number
CA2871585A1
CA2871585A1 CA2871585A CA2871585A CA2871585A1 CA 2871585 A1 CA2871585 A1 CA 2871585A1 CA 2871585 A CA2871585 A CA 2871585A CA 2871585 A CA2871585 A CA 2871585A CA 2871585 A1 CA2871585 A1 CA 2871585A1
Authority
CA
Canada
Prior art keywords
beta
capturing
blood
binding agent
amyloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2871585A
Other languages
English (en)
French (fr)
Inventor
Rogelio B. Santos, Jr.
Stanley Stein
Chinnaswamy Kasinathan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amylex Pharmaceuticals Inc
Original Assignee
Amylex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amylex Pharmaceuticals Inc filed Critical Amylex Pharmaceuticals Inc
Publication of CA2871585A1 publication Critical patent/CA2871585A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • External Artificial Organs (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2871585A 2012-04-26 2013-01-30 Novel composition for extracorporeal reduction of beta-amyloids and process for producing thereof Pending CA2871585A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261638672P 2012-04-26 2012-04-26
US61/638,672 2012-04-26
PCT/PH2013/000005 WO2013162387A1 (en) 2012-04-26 2013-01-30 Novel composition for extracorporeal reduction of beta-amyloids and process for producing thereof
PH1-2013-000037 2013-01-30
PH1/2013/000037A PH12013000037A1 (en) 2013-01-30 2013-01-30 Novel composition for extracorporeal reduction of beta-amyloids and process for producing thereof

Publications (1)

Publication Number Publication Date
CA2871585A1 true CA2871585A1 (en) 2013-10-31

Family

ID=49483563

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2871585A Pending CA2871585A1 (en) 2012-04-26 2013-01-30 Novel composition for extracorporeal reduction of beta-amyloids and process for producing thereof

Country Status (19)

Country Link
US (1) US20150087591A1 (enExample)
EP (1) EP2841447B1 (enExample)
JP (1) JP2015515491A (enExample)
KR (2) KR20180117226A (enExample)
CN (2) CN104662032A (enExample)
AU (2) AU2013253098A1 (enExample)
CA (1) CA2871585A1 (enExample)
DK (1) DK2841447T3 (enExample)
ES (1) ES2685374T3 (enExample)
HR (1) HRP20181365T1 (enExample)
IN (1) IN2014MN02137A (enExample)
LT (1) LT2841447T (enExample)
PH (1) PH12013000037A1 (enExample)
PL (1) PL2841447T3 (enExample)
RS (1) RS57651B1 (enExample)
SG (1) SG11201406972UA (enExample)
SI (1) SI2841447T1 (enExample)
SM (1) SMT201800445T1 (enExample)
WO (1) WO2013162387A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106800590B (zh) * 2015-11-25 2021-04-09 杭州智鹤丹谷生物医药有限公司 一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用
CN105651840B (zh) * 2016-04-01 2017-12-26 商丘师范学院 一种检测β‑淀粉样蛋白寡聚体的类免疫电化学传感器及其制备方法
CN109954128A (zh) * 2019-03-08 2019-07-02 南开大学 一种可干扰β-淀粉样蛋白聚集并协助清除的功能化纳米凝胶及制备方法
CN114933635B (zh) * 2021-08-29 2023-05-19 武汉夫图生物科技有限公司 纳米小肽fh及其在制备治疗及预防眼底血管疾病药物中的应用
CA3239637A1 (en) * 2021-12-23 2023-06-29 Fresenius Medical Care Holdings, Inc. Compounds, systems, and techniques for removal of peripheral amyloid beta peptide with albumin binding competitors
CN115337388A (zh) * 2022-07-01 2022-11-15 南方医科大学 一种抗菌和预防hpv病毒的按需释放凝胶及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5223199B2 (enExample) * 1972-05-27 1977-06-22
JPS4942189A (enExample) * 1972-08-29 1974-04-20
CA2214247C (en) * 1995-03-14 2004-02-10 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
JPH09157283A (ja) * 1995-12-13 1997-06-17 Tatsuaki Yamaguchi 燐酸吸着コロイド
US6022859A (en) * 1996-11-15 2000-02-08 Wisconsin Alumni Research Foundation Inhibitors of β-amyloid toxicity
AU2003303198A1 (en) * 2002-12-19 2004-07-14 New York University Method for treating amyloid disease
US20060069010A1 (en) * 2003-10-17 2006-03-30 Senicure Llc Detoxification depot for Alzheimer's disease
US20070092508A1 (en) * 2005-10-21 2007-04-26 Recombiant Technologies, Llc Detoxification depot for Alzheimer's disease
CA2780645C (en) * 2009-11-18 2018-01-16 Nektar Therapeutics Salt form of a multi-arm polymer-drug conjugate
CN102108119A (zh) * 2009-12-25 2011-06-29 天津键凯科技有限公司 多臂聚乙二醇衍生物及其与药物的结合物和凝胶
JP5843345B2 (ja) * 2010-07-08 2016-01-13 旭化成メディカル株式会社 β−アミロイド除去システム

Also Published As

Publication number Publication date
EP2841447B1 (en) 2018-06-13
RS57651B1 (sr) 2018-11-30
PH12013000037A1 (en) 2013-10-14
KR20180117226A (ko) 2018-10-26
US20150087591A1 (en) 2015-03-26
AU2016208257B2 (en) 2018-08-16
DK2841447T3 (en) 2018-09-03
EP2841447A4 (en) 2015-10-28
PL2841447T3 (pl) 2019-03-29
JP2015515491A (ja) 2015-05-28
CN104662032A (zh) 2015-05-27
AU2016208257A1 (en) 2016-08-11
IN2014MN02137A (enExample) 2015-08-21
HRP20181365T1 (hr) 2018-10-19
AU2013253098A2 (en) 2015-04-30
WO2013162387A1 (en) 2013-10-31
SI2841447T1 (sl) 2018-10-30
CN109731169A (zh) 2019-05-10
ES2685374T3 (es) 2018-10-08
LT2841447T (lt) 2018-09-10
EP2841447A1 (en) 2015-03-04
AU2013253098A1 (en) 2014-11-13
SMT201800445T1 (it) 2018-09-13
SG11201406972UA (en) 2014-11-27
KR20150022753A (ko) 2015-03-04

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