CA2868507A1 - Methods for improving diaphragm function - Google Patents
Methods for improving diaphragm function Download PDFInfo
- Publication number
- CA2868507A1 CA2868507A1 CA2868507A CA2868507A CA2868507A1 CA 2868507 A1 CA2868507 A1 CA 2868507A1 CA 2868507 A CA2868507 A CA 2868507A CA 2868507 A CA2868507 A CA 2868507A CA 2868507 A1 CA2868507 A1 CA 2868507A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- pyrazin
- imidazo
- optionally substituted
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 239000007858 starting material Substances 0.000 description 1
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- 125000004646 sulfenyl group Chemical group S(*)* 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 125000002769 thiazolinyl group Chemical group 0.000 description 1
- RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical compound C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
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| US201261619261P | 2012-04-02 | 2012-04-02 | |
| US61/619,261 | 2012-04-02 | ||
| PCT/US2013/034824 WO2013151938A1 (en) | 2012-04-02 | 2013-04-01 | Methods for improving diaphragm function |
Publications (1)
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| CA2868507A1 true CA2868507A1 (en) | 2013-10-10 |
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| CA2868507A Abandoned CA2868507A1 (en) | 2012-04-02 | 2013-04-01 | Methods for improving diaphragm function |
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| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| EP2723746A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| US10272082B2 (en) | 2011-07-13 | 2019-04-30 | Cytokinetics, Inc. | Combination ALS therapy |
| SG10201704166RA (en) * | 2012-04-11 | 2017-06-29 | Cytokinetics Inc | Improving resistance to skeletal muscle fatigue |
| EP4534538A3 (en) | 2012-12-07 | 2025-06-11 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| AU2014229313B2 (en) | 2013-03-14 | 2016-07-28 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH |
| WO2014143240A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
| US8969360B2 (en) | 2013-03-15 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2014143241A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CA2932757C (en) | 2013-12-06 | 2023-10-31 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| RS63018B1 (sr) | 2014-04-29 | 2022-04-29 | Cytokinetics Inc | Metode za smanjenje opadanja vitalnog kapaciteta |
| RU2719583C2 (ru) | 2014-06-05 | 2020-04-21 | Вертекс Фармасьютикалз Инкорпорейтед | Радиоактивно меченные производные 2-амино-6-фтор-n-[5-фтор-пиридин-3-ил]-пиразоло[1, 5-а]пиримидин-3-карбоксамида, используемые в качестве ингибитора atr киназы, препараты на основе этого соединения и его различные твердые формы |
| SG11201610500WA (en) | 2014-06-17 | 2017-01-27 | Vertex Pharma | Method for treating cancer using a combination of chk1 and atr inhibitors |
| US9987279B2 (en) * | 2014-09-09 | 2018-06-05 | Astellas Pharma Inc. | Pharmaceutical composition for prevention and/or treatment of urinary incontinence |
| JP2018516254A (ja) | 2015-05-29 | 2018-06-21 | ファイザー・インク | バニン１酵素の阻害薬としての新規なヘテロ環化合物 |
| KR102678021B1 (ko) | 2015-09-30 | 2024-06-26 | 버텍스 파마슈티칼스 인코포레이티드 | Dna 손상제와 병용되는, atr 저해제를 포함하는 암 치료용 약제학적 조성물 |
| CN113666938A (zh) | 2016-02-12 | 2021-11-19 | 细胞动力学股份有限公司 | 四氢异喹啉衍生物 |
| EP3484876A1 (en) | 2016-07-14 | 2019-05-22 | Pfizer Inc | Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme |
| WO2020254343A1 (en) * | 2019-06-19 | 2020-12-24 | F. Hoffmann-La Roche Ag | Digital biomarker |
| CN114007495A (zh) | 2019-06-19 | 2022-02-01 | 豪夫迈·罗氏有限公司 | 数字生物标志物 |
| BR112022000325A2 (pt) | 2019-07-11 | 2022-03-15 | Escape Bio Inc | Indazois e azaindazois como inibidores de lrrk2 |
| US11981644B2 (en) | 2020-11-06 | 2024-05-14 | Cytokinetics, Inc. | Bicyclic 1,4-diazepanones and therapeutic uses thereof |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| US20240382564A1 (en) * | 2023-04-17 | 2024-11-21 | Allysta Pharmaceuticals, Inc. | Methods and Compositions for Treating Muscular Dystrophy and Memory Impairment |
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| US20070173465A9 (en) * | 1995-10-11 | 2007-07-26 | Monahan Sean D | Expression of zeta negative and zeta positive nucleic acids using a dystrophin gene |
| AU2001268149B2 (en) * | 2000-06-01 | 2005-08-18 | University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| CN1283793C (zh) * | 2002-06-03 | 2006-11-08 | 北京大学 | 具有骨骼肌刺激活性和免疫调节作用的趋化素样因子超家族 |
| EP1651638A1 (en) * | 2003-08-08 | 2006-05-03 | Janssen Pharmaceutica N.V. | Pyridyl piperazinyl ureas |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| DK2069352T5 (en) * | 2006-08-02 | 2017-04-03 | Cytokinetics Inc | SPECIFIC CHEMICAL UNITS, COMPOSITIONS AND PROCEDURES |
| US8299248B2 (en) * | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| WO2009023193A1 (en) * | 2007-08-15 | 2009-02-19 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
| NL2001694C2 (en) * | 2008-06-18 | 2009-12-22 | Nasophlex B V | Ear stimulator for producing a stimulation signal to an ear. |
| AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| AR081626A1 (es) * | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
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2013
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- 2013-04-01 BR BR112014024552A patent/BR112014024552A2/pt not_active Application Discontinuation
- 2013-04-01 EP EP13773086.7A patent/EP2834269A4/en not_active Withdrawn
- 2013-04-01 EA EA201491605A patent/EA031183B1/ru not_active IP Right Cessation
- 2013-04-01 KR KR1020147027435A patent/KR20160046693A/ko not_active Abandoned
- 2013-04-01 CN CN201810509450.1A patent/CN108553467A/zh active Pending
- 2013-04-01 US US14/389,805 patent/US20150065525A1/en not_active Abandoned
- 2013-04-01 CA CA2868507A patent/CA2868507A1/en not_active Abandoned
- 2013-04-01 MX MX2014011881A patent/MX354965B/es active IP Right Grant
- 2013-04-01 AU AU2013243671A patent/AU2013243671B2/en not_active Ceased
- 2013-04-01 WO PCT/US2013/034824 patent/WO2013151938A1/en not_active Ceased
- 2013-04-01 SG SG10201701101YA patent/SG10201701101YA/en unknown
- 2013-04-01 JP JP2015503681A patent/JP6345645B2/ja not_active Expired - Fee Related
- 2013-04-01 HK HK15106936.7A patent/HK1206364A1/xx unknown
- 2013-04-01 CN CN201380018757.7A patent/CN104379597A/zh active Pending
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2014
- 2014-09-29 IL IL234885A patent/IL234885A0/en unknown
- 2014-10-01 PH PH12014502217A patent/PH12014502217A1/en unknown
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2017
- 2017-02-27 US US15/444,063 patent/US20170266192A1/en not_active Abandoned
- 2017-12-07 AU AU2017272286A patent/AU2017272286B2/en not_active Ceased
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2018
- 2018-05-23 JP JP2018098858A patent/JP2018131460A/ja not_active Ceased
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2019
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2020
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| MX354965B (es) | 2018-03-27 |
| HK1206364A1 (en) | 2016-01-08 |
| BR112014024552A2 (pt) | 2017-09-19 |
| AU2013243671B2 (en) | 2017-09-21 |
| JP2015516957A (ja) | 2015-06-18 |
| US20170266192A1 (en) | 2017-09-21 |
| AU2013243671A1 (en) | 2014-10-16 |
| JP2018131460A (ja) | 2018-08-23 |
| JP6345645B2 (ja) | 2018-06-20 |
| IL267876B (en) | 2021-03-25 |
| MX2014011881A (es) | 2016-07-20 |
| SG11201406270YA (en) | 2014-10-30 |
| US20150065525A1 (en) | 2015-03-05 |
| AU2017272286A1 (en) | 2018-01-04 |
| EP2834269A1 (en) | 2015-02-11 |
| PH12014502217A1 (en) | 2015-01-12 |
| JP2020147607A (ja) | 2020-09-17 |
| SG10201701101YA (en) | 2017-04-27 |
| CN108553467A (zh) | 2018-09-21 |
| EP2834269A4 (en) | 2015-12-30 |
| EA031183B1 (ru) | 2018-11-30 |
| KR20160046693A (ko) | 2016-04-29 |
| CN104379597A (zh) | 2015-02-25 |
| AU2017272286B2 (en) | 2019-05-09 |
| EA201491605A1 (ru) | 2015-03-31 |
| WO2013151938A1 (en) | 2013-10-10 |
| IL267876A (en) | 2019-09-26 |
| IL234885A0 (en) | 2014-12-31 |
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